Paper1069185
Synthetic lac operator DNA is functional in vivo.
Heyneker HL and 9 others. Nature, 1976. Cited by 157 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. Synthetic lac operator DNA is functional in vivo. Papers, record 1069185. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/1069185
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Publication types
- Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
- PubMed
Topics12
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| DNA, Bacterial | Major topic |
| DNA, Recombinant | Major topic |
| Genes, Regulator | Major topic |
| Genetic Engineering | Major topic |
| Lactose | Major topic |
| Bacterial Proteins | |
| DNA Restriction Enzymes | |
| Enzyme Repression | |
| Galactosidases | |
| Operon | |
| Plasmids | |
| Protein Binding |
Source PubMed
Cited by43
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 157 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 38,750,104 | POSoligo software for in vitro gene synthesis. | Sci Rep | 2024 | https://conductscience.org/library/papers/38750104 | PubMed |
| 36,085,502 | Arthur D. Riggs 1939-2022. | Nat Biotechnol | 2022 | https://conductscience.org/library/papers/36085502 | PubMed |
| 35,478,326 | Standardization of regulatory nodes for engineering heterologous gene expression: a feasibility study. | Microb Biotechnol | 2022 | https://conductscience.org/library/papers/35478326 | PubMed |
| 33,340,315 | Making, Cloning, and the Expression of Human Insulin Genes in Bacteria: The Path to Humulin. | Endocr Rev | 2021 | https://conductscience.org/library/papers/33340315 | PubMed |
| 32,218,528 | Function-based high-throughput screening for antibody antagonists and agonists against G protein-coupled receptors. | Commun Biol | 2020 | https://conductscience.org/library/papers/32218528 | PubMed |
| 23,300,917 | Exponential megapriming PCR (EMP) cloning--seamless DNA insertion into any target plasmid without sequence constraints. | PLoS One | 2012 | https://conductscience.org/library/papers/23300917 | PubMed |
| 20,332,218 | Profile of Arthur D. Riggs. | Proc Natl Acad Sci U S A | 2010 | https://conductscience.org/library/papers/20332218 | PubMed |
| 18,000,550 | Rapid assembly of multiple-exon cDNA directly from genomic DNA. | PLoS One | 2007 | https://conductscience.org/library/papers/18000550 | PubMed |
| 17,242,375 | Protein fabrication automation. | Protein Sci | 2007 | https://conductscience.org/library/papers/17242375 | PubMed |
| 16,593,514 | Expression of beta-galactosidase controlled by a nitrogenase promoter in stem nodules of Aeschynomene scabra. | Proc Natl Acad Sci U S A | 1984 | https://conductscience.org/library/papers/16593514 | PubMed |
| 15,215,375 | Gene2Oligo: oligonucleotide design for in vitro gene synthesis. | Nucleic Acids Res | 2004 | https://conductscience.org/library/papers/15215375 | PubMed |
| 12,000,848 | DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis. | Nucleic Acids Res | 2002 | https://conductscience.org/library/papers/12000848 | PubMed |
| 9,279,398 | Expression of the mouse dihydrofolate reductase complementary deoxyribonucleic acid in simian virus 40 vectors. | Mol Cell Biol | 1981 | https://conductscience.org/library/papers/9279398 | PubMed |
| 7,041,119 | Segment-specific mutagenesis: extensive mutagenesis of a lac promoter/operator element. | Proc Natl Acad Sci U S A | 1982 | https://conductscience.org/library/papers/7041119 | PubMed |
| 6,750,604 | Sequences of the Escherichia coli dnaG primase gene and regulation of its expression. | Proc Natl Acad Sci U S A | 1982 | https://conductscience.org/library/papers/6750604 | PubMed |
| 6,390,428 | Regulation of ribosomal RNA promoters with a synthetic lac operator. | Proc Natl Acad Sci U S A | 1984 | https://conductscience.org/library/papers/6390428 | PubMed |
| 6,337,371 | The tac promoter: a functional hybrid derived from the trp and lac promoters. | Proc Natl Acad Sci U S A | 1983 | https://conductscience.org/library/papers/6337371 | PubMed |
| 6,336,738 | Nitrogen fixation by Klebsiella pneumoniae is inhibited by certain multicopy hybrid nif plasmids. | J Bacteriol | 1983 | https://conductscience.org/library/papers/6336738 | PubMed |
| 6,327,616 | D-ribose metabolism in Escherichia coli K-12: genetics, regulation, and transport. | J Bacteriol | 1984 | https://conductscience.org/library/papers/6327616 | PubMed |
| 6,278,439 | Overlapping genes at the DNA primase locus of the large plasmid ColI. | Nucleic Acids Res | 1982 | https://conductscience.org/library/papers/6278439 | PubMed |
Genes1
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes |
|---|---|---|---|
| LCT | 3,938 | PubTator's text mining | https://conductscience.org/library/genes/3938 |
Source NCBI Gene
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
None in this release
- Grants
- Trials
- Comments and corrections
- References
- Drugs
- Data
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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