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Paper · 10698947

Intimate adhesion of Neisseria meningitidis to human epithelial cells is under the control of the crgA gene, a novel LysR-type transcriptional regulator.

Deghmane AE and 6 others. EMBO J, 2000. Cited by 74 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Intimate adhesion of Neisseria meningitidis to human epithelial cells is under the control of the crgA gene, a novel LysR-type transcriptional regulator. Papers, record 10698947. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/10698947

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Intimate adhesion of Neisseria meningitidis to human epithelial cells is under the control of the crgA gene, a novel LysR-type transcriptional regulator.
PubMed
Journal
EMBO J
PubMed
Year
2000
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
74
iCite
Relative citation ratio, by iCite
1.78
iCite
Revised in PubMed
2018-11-13
PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Deghmane AEA E
2Petit SS
3Topilko AA
4Pereira YY
5Giorgini DD
6Larribe MM
7Taha MKM K

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Bacterial AdhesionMajor topic
Bacterial ProteinsMajor topic
Epithelial CellsMajor topic
Meningococcal InfectionsMajor topic
Neisseria meningitidisMajor topic
Transcription FactorsMajor topic
Base Sequence
Cell Line
Gene Expression Regulation, Bacterial
Humans
Molecular Sequence Data

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References30

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
17,909,606Roles of pilin and PilC in adhesion of Neisseria meningitidis to human epithelial and endothelial cells.Proc Natl Acad Sci U S A1994https://conductscience.org/library/papers/7909606PubMed
28,257,110Molecular biology of the LysR family of transcriptional regulators.Annu Rev Microbiol1993https://conductscience.org/library/papers/8257110PubMed
37,773,412Organization of carbamoyl-phosphate synthase genes in Neisseria gonorrhoeae includes a large, variable intergenic sequence which is also present in other Neisseria species.Microbiology (Reading)1995https://conductscience.org/library/papers/7773412PubMed
47,568,050A general genetic approach in Escherichia coli for determining the mechanism(s) of action of tumoricidal agents: application to DMP 840, a tumoricidal agent.Proc Natl Acad Sci U S A1995https://conductscience.org/library/papers/7568050PubMed
58,830,264The pilA regulatory gene modulates the pilus-mediated adhesion of Neisseria meningitidis by controlling the transcription of pilC1.Mol Microbiol1996https://conductscience.org/library/papers/8830264PubMed
68,971,715Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriae.Mol Microbiol1996https://conductscience.org/library/papers/8971715PubMed
79,041,426Genetic analysis of a meningococcal population based on polymorphism of the pilA-pilB locus: a molecular approach for meningococcal epidemiology.J Clin Microbiol1997https://conductscience.org/library/papers/9041426PubMed
89,218,786CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes.EMBO J1997https://conductscience.org/library/papers/9218786PubMed
99,221,754Neisseria gonorrhoeae epithelial cell interaction leads to the activation of the transcription factors nuclear factor kappaB and activator protein 1 and the induction of inflammatory cytokines.J Exp Med1997https://conductscience.org/library/papers/9221754PubMed
109,353,073Interaction of Neisseria meningitidis with a polarized monolayer of epithelial cells.Infect Immun1997https://conductscience.org/library/papers/9353073PubMed

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Cited by32

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 74 citations.

PMIDTitleJournalYearIn PapersSource
41,309,349PilY proteins: bimodular drivers of type IV pilus versatility.Trends Microbiol2026https://conductscience.org/library/papers/41309349PubMed
40,586,572Impact of host factors and invasive meningococci on bacterial adhesion, proliferation, primary nasal epithelial barrier function, and immune response.Microbiol Spectr2025https://conductscience.org/library/papers/40586572PubMed
40,539,451Type IV pilin regulation: a transcriptional overview.Crit Rev Microbiol2026https://conductscience.org/library/papers/40539451PubMed
37,715,803Fine-tuning gene expression of regulator AdmX for improved biosynthesis of andrimid in Erwinia persicina BST187.Appl Microbiol Biotechnol2023https://conductscience.org/library/papers/37715803PubMed
35,531,336The Host-Pathogen Interactions and Epicellular Lifestyle of Neisseria meningitidis.Front Cell Infect Microbiol2022https://conductscience.org/library/papers/35531336PubMed
32,843,554Identification of a Novel LysR-Type Transcriptional Regulator in Staphylococcus aureus That Is Crucial for Secondary Tissue Colonization during Metastatic Bloodstream Infection.mBio2020https://conductscience.org/library/papers/32843554PubMed
30,915,046CrgA Protein Represses AlkB2 Monooxygenase and Regulates the Degradation of Medium-to-Long-Chain n-Alkanes in Pseudomonas aeruginosa SJTD-1.Front Microbiol2019https://conductscience.org/library/papers/30915046PubMed
28,384,279Host cell-derived lactate functions as an effector molecule in Neisseria meningitidis microcolony dispersal.PLoS Pathog2017https://conductscience.org/library/papers/28384279PubMed
28,187,184The FinR-regulated essential gene fprA, encoding ferredoxin NADP+ reductase: Roles in superoxide-mediated stress protection and virulence of Pseudomonas aeruginosa.PLoS One2017https://conductscience.org/library/papers/28187184PubMed
23,093,386Modulation of Kingella kingae adherence to human epithelial cells by type IV Pili, capsule, and a novel trimeric autotransporter.mBio2012https://conductscience.org/library/papers/23093386PubMed

1 to 10 of 32

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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