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Paper11680853

Synthesis and properties of mRNAs containing the novel "anti-reverse" cap analogs 7-methyl(3'-O-methyl)GpppG and 7-methyl (3'-deoxy)GpppG.

Stepinski J and 4 others. RNA, 2001. Cited by 322 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Synthesis and properties of mRNAs containing the novel "anti-reverse" cap analogs 7-methyl(3'-O-methyl)GpppG and 7-methyl (3'-deoxy)GpppG. Papers, record 11680853. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/11680853

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Synthesis and properties of mRNAs containing the novel "anti-reverse" cap analogs 7-methyl(3'-O-methyl)GpppG and 7-methyl (3'-deoxy)GpppG.
PubMed
Journal
RNA
PubMed
Year
2001
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
322
iCite
Relative citation ratio, by iCite
5.09
iCite
Revised in PubMed
2018-11-13
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Stepinski JJ
2Waddell CC
3Stolarski RR
4Darzynkiewicz EE
5Rhoads RER E

Source PubMed

Topics5

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Dinucleoside PhosphatesMajor topic
RNA CapsMajor topic
RNA, MessengerMajor topic
Nuclear Magnetic Resonance, Biomolecular
Protein Biosynthesis

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
GM20818NIGMS NIH HHSUnited StatesPubMed

Source PubMed

References17

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
18,548,660Reverse 5' caps in RNAs made in vitro by phage RNA polymerases.RNA1995https://conductscience.org/library/papers/8548660PubMed
22,559,301Synthesis of long, capped transcripts in vitro by SP6 and T7 RNA polymerases.Methods Enzymol1989https://conductscience.org/library/papers/2559301PubMed
39,302,999Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein.Nat Struct Biol1997https://conductscience.org/library/papers/9302999PubMed
49,396,631Fluorescence and NMR studies of intramolecular stacking of mRNA cap-analogues.Biochim Biophys Acta1997https://conductscience.org/library/papers/9396631PubMed
510,387,101Quantitative assessment of mRNA cap analogues as inhibitors of in vitro translation.Biochemistry1999https://conductscience.org/library/papers/10387101PubMed
62,334,695A spectroscopic study of the binding of N-7-substituted cap analogues to human protein synthesis initiation factor 4E.Biochemistry1990https://conductscience.org/library/papers/2334695PubMed
74,917,900
Synthesis and chemical properties of monomers and polymers containing 7-methylguanine and an investigation of their substrate or template properties for bacterial deoxyribonucleic acid or ribonucleic acid polymerases.
Biochemistry1970https://conductscience.org/library/papers/4917900PubMed
81,061,116Inhibition of initiation of protein synthesis by 7-methylguanosine-5'-monophosphate.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/1061116PubMed
9179,883Translational discrimination of 'capped' and 'non-capped' mRNAS: inhibition of a series of chemical analogs of m7GpppX.FEBS Lett1976https://conductscience.org/library/papers/179883PubMed
106,294,601Simple, efficient in vitro synthesis of capped RNA useful for direct expression of cloned eukaryotic genes.Nucleic Acids Res1982https://conductscience.org/library/papers/6294601PubMed
116,326,408Conformation about the glycosidic bond and susceptibility to 5'-nucleotidase of 8-substituted analogues of 5'-GMP.Z Naturforsch C Biosci1984https://conductscience.org/library/papers/6326408PubMed
126,567,484Recognition of cap structure in splicing in vitro of mRNA precursors.Cell1984https://conductscience.org/library/papers/6567484PubMed
133,967,293mRNA cap binding proteins: essential factors for initiating translation.Cell1985https://conductscience.org/library/papers/3967293PubMed
142,944,599Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding.Cell1986https://conductscience.org/library/papers/2944599PubMed
153,325,057mRNA caps--old and newer hats.Bioessays1987https://conductscience.org/library/papers/3325057PubMed
166,400,827Carbon-13 NMR in conformational analysis of nucleic acid fragments. 2. A reparametrization of the Karplus equation for vicinal NMR coupling constants in CCOP and HCOP fragments.J Biomol Struct Dyn1984https://conductscience.org/library/papers/6400827PubMed
179,200,613Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP.Cell1997https://conductscience.org/library/papers/9200613PubMed

Cited by208

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 322 citations.

PMIDTitleJournalYearIn PapersSource
42,959,525An activator-free method for the synthesis of nucleotide 5'-5' triphosphate mRNA capping agent.RSC Adv2026https://conductscience.org/library/papers/42959525PubMed
42,654,058Two Classes of Protein Therapeutics: Why Dose-Response Architecture Defines the Boundary of mRNA Medicines.Pharmaceutics2026https://conductscience.org/library/papers/42654058PubMed
42,565,117Beyond the genetic code: orchestrating epigenetic and immune landscapes with multivalent mRNA-exosome vaccines.Precis Clin Med2026https://conductscience.org/library/papers/42565117PubMed
42,514,871Analytical Characterization and Stability Assessment of RNA-Based Vaccines.Pharmaceutics2026https://conductscience.org/library/papers/42514871PubMed
42,236,989Towards mRNA therapeutics 2.0.Nat Rev Drug Discov2026https://conductscience.org/library/papers/42236989PubMed
42,205,550Transcript-independent quantitative analysis of RNA cap structures by LC-MS/MS.Mol Ther Adv2026https://conductscience.org/library/papers/42205550PubMed
42,087,788Omnivore RNA pyrophosphatase: a versatile enzyme that efficiently removes diverse protecting groups from the 5' end of RNA.Nucleic Acids Res2026https://conductscience.org/library/papers/42087788PubMed
42,079,517Enhancing mRNA stability and translational potential through tailored modifications at the 3' end.RSC Chem Biol2026https://conductscience.org/library/papers/42079517PubMed
42,003,885Unlocking the potential of mRNA nanomedicines for comprehensive fibrosis therapy.Mol Ther Nucleic Acids2026https://conductscience.org/library/papers/42003885PubMed
41,932,444A systematic review on vaccine developmental approaches: Evaluating efficacy, and addressing challenges of infectious diseases in the post-COVID-19 era.Virus Res2026https://conductscience.org/library/papers/41932444PubMed
41,875,901Beyond the Sequence: Chemical and Topological Design and Innovations in mRNA Therapeutics.Chem Rev2026https://conductscience.org/library/papers/41875901PubMed
41,773,826Sperm motility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA.Elife2026https://conductscience.org/library/papers/41773826PubMed
41,748,156"More" Artificial mRNAs: Beyond the Art of Nature.Adv Sci (Weinh)2026https://conductscience.org/library/papers/41748156PubMed
41,619,255The 5' Cap Epitranscriptome and Beyond: Natural and Engineered 5' Cap Modifications for Optimizing mRNA Therapeutics and Functional Studies.ChemMedChem2026https://conductscience.org/library/papers/41619255PubMed
41,557,011Process and analytical strategies for the safe production of mRNA vaccines and therapeutics.Mol Biol Rep2026https://conductscience.org/library/papers/41557011PubMed
41,535,643The mRNA-Based Innovative Strategy: Progress and Challenges.Nanomicro Lett2026https://conductscience.org/library/papers/41535643PubMed
41,512,965RNA-Based Therapies for Treating Monogenic Cardiomyopathies.Can J Cardiol2026https://conductscience.org/library/papers/41512965PubMed
41,366,793Convergence of mRNA technology and chimeric antigen receptor therapy: targeted technology optimizing targeted therapy.J Transl Med2025https://conductscience.org/library/papers/41366793PubMed
41,310,620mRNA vaccines: immunogenicity and quality characteristics.J Nanobiotechnology2025https://conductscience.org/library/papers/41310620PubMed
41,264,102RNA-based cancer vaccines: mechanisms, clinical progress, and translational challenges.Immunol Res2025https://conductscience.org/library/papers/41264102PubMed

See all 208 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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