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Paper · 12414734

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.

Akiyama H and 4 others. Genes Dev, 2002. Cited by 1,425 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Papers, record 12414734. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/12414734

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.
PubMed
Journal
Genes Dev
PubMed
Year
2002
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
1,425
iCite
Relative citation ratio, by iCite
28.7
iCite
Revised in PubMed
2025-10-22
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Akiyama HHaruhiko
2Chaboissier MCMarie-Christine
3Martin JFJames F
4Schedl AAndreas
5de Crombrugghe BBenoit

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cell DifferentiationMajor topic
ChondrocytesMajor topic
DNA-Binding ProteinsMajor topic
High Mobility Group ProteinsMajor topic
Nuclear ProteinsMajor topic
Transcription FactorsMajor topic
Animals
Cell Division
Gene Expression Regulation, Developmental
Mice
Mutation
SOX9 Transcription Factor
SOXD Transcription Factors
Signal Transduction

Source PubMed

Grants9

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P30 CA016672NCI NIH HHSUnited StatesP01CA016672PubMed and NIHNIH RePORTER
CA16672NCI NIH HHSUnited StatesP01CA016672PubMed and NIHNIH RePORTER
R01DE013509NIDCR NIH HHSUnited StatesR01DE013509PubMed and NIHNIH RePORTER
R29 DE012324NIDCR NIH HHSUnited StatesR29DE012324PubMed and NIHNIH RePORTER
R29 DE12324NIDCR NIH HHSUnited StatesR29DE012324PubMed and NIHNIH RePORTER
P01 AR042919NIAMS NIH HHSUnited StatesP01AR042919PubMed and NIHNIH RePORTER
P01AR42919NIAMS NIH HHSUnited StatesP01AR042919PubMed and NIHNIH RePORTER
R01 DE013509NIDCR NIH HHSUnited StatesR01DE013509PubMed and NIHNIH RePORTER
P30CA016672NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References45

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
110,556,075The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb.Development1999https://conductscience.org/library/papers/10556075PubMed
210,465,785Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.Genes Dev1999https://conductscience.org/library/papers/10465785PubMed
310,668,469Bone morphogenetic proteins regulate interdigital cell death in the avian embryo.Ann N Y Acad Sci1999https://conductscience.org/library/papers/10668469PubMed
410,686,612Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice.Genesis2000https://conductscience.org/library/papers/10686612PubMed
510,748,458Identification of a prx1 limb enhancer.Genesis2000https://conductscience.org/library/papers/10748458PubMed
610,753,864SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6.J Biol Chem2000https://conductscience.org/library/papers/10753864PubMed
710,862,751Dual roles of Wnt signaling during chondrogenesis in the chicken limb.Development2000https://conductscience.org/library/papers/10862751PubMed
811,180,395Reciprocal control of osteoblast/chondroblast and osteoblast/adipocyte differentiation of multipotential clonal human marrow stromal F/STRO-1(+) cells.J Cell Biochem2001https://conductscience.org/library/papers/11180395PubMed
911,239,392Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton.Cell2001https://conductscience.org/library/papers/11239392PubMed
1011,371,614Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization.Proc Natl Acad Sci U S A2001https://conductscience.org/library/papers/11371614PubMed

1 to 10 of 45

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Cited by821

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,425 citations.

PMIDTitleJournalYearIn PapersSource
42,835,342Molecular analysis of Aldh1a2 conditional inactivation in developing limbs reveals mechanisms of retinoic-acid mediated interdigital apoptosis.Front Cell Dev Biol2026https://conductscience.org/library/papers/42835342PubMed
42,823,400Vascular calcification: pathogenic mechanisms, signaling crosstalk and translational therapeutics.Signal Transduct Target Ther2026https://conductscience.org/library/papers/42823400PubMed
42,818,368A Human Accelerated Region Drives Opposing Heterochronic Changes in Craniofacial and Limb Development.bioRxiv2026https://conductscience.org/library/papers/42818368PubMed
42,807,934Human-Mouse Chimerism for Organogenesis Without Neural or Germline Contributions.Int J Biol Sci2026https://conductscience.org/library/papers/42807934PubMed
42,791,837An Efficient Spheroid Manufacturing Workflow for WJ-MSCs: Comparative Evaluation of Immediate 3D Aggregation and Conventional 2D Stabilization.Bioengineering (Basel)2026https://conductscience.org/library/papers/42791837PubMed
42,635,596Intra-Articular miR-199a-5p Attenuates Post-traumatic Ankle Cartilage Degeneration With Reduced IHH Expression and Hypertrophic-Catabolic Marker Expression.Cartilage2026https://conductscience.org/library/papers/42635596PubMed
42,631,664Network Model to Predict Age-Related Transcriptional Reprogramming.Aging Cell2026https://conductscience.org/library/papers/42631664PubMed
42,581,656Regulation of lambdoid suture morphogenesis by PDGFRα-dependent chondrocyte programs.Development2026https://conductscience.org/library/papers/42581656PubMed
42,402,925Epigenetic regulation of vertebrate limb development: from field specification to tissue morphogenesis.Epigenetics2026https://conductscience.org/library/papers/42402925PubMed
42,304,424SOX9: dosage- and context-dependent functions in pancreatic development and β-cell biology.Cell Commun Signal2026https://conductscience.org/library/papers/42304424PubMed

1 to 10 of 821

See all 821 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
SOX96,662PubTator's text mininghttps://conductscience.org/library/genes/6662

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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