Paper · 1460

Intracellular pH transients in squid giant axons caused by CO2, NH3, and metabolic inhibitors.

Boron WF and 1 other. J Gen Physiol, 1976. Cited by 876 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Intracellular pH transients in squid giant axons caused by CO2, NH3, and metabolic inhibitors. Papers, record 1460. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/1460

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Intracellular pH transients in squid giant axons caused by CO2, NH3, and metabolic inhibitors.; PubMed
Journal: J Gen Physiol; PubMed
Year: 1976; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/1460/; PubMed
DOI: https://doi.org/10.1085/jgp.67.1.91; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2214912/; PubMed
The journal: https://conductscience.org/library/journal-index/2985110R; PubMed
Citations, by iCite: 876; iCite
Relative citation ratio, by iCite: 24.3; iCite
Revised in PubMed: 2022-03-09; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Boron WF	W F
2	De Weer P	P

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Ammonium Chloride	Major topic
Antimetabolites	Major topic
Axons	Major topic
Carbon Dioxide	Major topic
Hydrogen-Ion Concentration	Major topic
Animals
Azides
Cyanides
Decapodiformes
Dinitrophenols
Models, Biological

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References13

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,537,783	An imidazole alphastat hypothesis for vertebrate acid-base regulation: tissue carbon dioxide content and body temperature in bullfrogs.	Respir Physiol	1972	https://conductscience.org/library/papers/4537783	PubMed
2	4,838,803	Intracellular pH of snail neurones measured with a new pH-sensitive glass mirco-electrode.	J Physiol	1974	https://conductscience.org/library/papers/4838803	PubMed
3	4,873,193	Optical density changes of single muscle fibres in sodium-free solutions.	Can J Physiol Pharmacol	1968	https://conductscience.org/library/papers/4873193	PubMed
4	5,412,482	Acid-base balance in cold-blooded vertebrates as a function of body temperature.	Am J Physiol	1970	https://conductscience.org/library/papers/5412482	PubMed
5	5,846,926	Intracellular pH and intracellular buffering power of the cat brain.	Am J Physiol	1965	https://conductscience.org/library/papers/5846926	PubMed
6	6,026,098	Measurement of intracellular pH of skeletal muscle with pH-sensitive glass microelectrodes.	J Clin Invest	1967	https://conductscience.org/library/papers/6026098	PubMed
7	4,443,901	Proceedings: The effect of bicarbonate on the intracellular buffering power of snail neurones.	J Physiol	1974	https://conductscience.org/library/papers/4443901	PubMed
8	5,020,230	Intracellular pH electrode. Experiments on the giant squid axon.	Biochim Biophys Acta	1972	https://conductscience.org/library/papers/5020230	PubMed
9	6,063,685	Sodium extrusion by internally dialyzed squid axons.	J Gen Physiol	1967	https://conductscience.org/library/papers/6063685	PubMed
12	13,689,933	The permeability of the squid giant axon to radioactive potassium and chloride ions.	J Physiol	1960	https://conductscience.org/library/papers/13689933	PubMed

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Cited by321

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 876 citations.

PMID	Title	Journal	Year	In Papers	Source
41,543,353	Vacuolar ATPase regulates ureteric bud branching morphogenesis during kidney development.	Am J Physiol Regul Integr Comp Physiol	2026	https://conductscience.org/library/papers/41543353	PubMed
41,542,472	Smoothened turnover regulated by Hedgehog signaling in Drosophila.	bioRxiv	2026	https://conductscience.org/library/papers/41542472	PubMed
41,432,597	Synergistic roles of aquaporin 5 and intra- and extracellular carbonic anhydrases in promoting CO2 diffusion across the Xenopus oocyte plasma membrane.	J Physiol	2026	https://conductscience.org/library/papers/41432597	PubMed
40,800,612	Validation of Hv1 channel functions in BV2 microglial cells using small molecule modulators.	Front Cell Neurosci	2025	https://conductscience.org/library/papers/40800612	PubMed
40,631,384	Loss of Na+,HCO3 --Cotransporter NBCn1 Inhibits Net Acid Extrusion in the Atria and Causes Hypertension-Associated Cardiac Hypertrophy.	Acta Physiol (Oxf)	2025	https://conductscience.org/library/papers/40631384	PubMed
40,627,702	Bioelectrosynthesis of Signaling Molecules for Selective Modulation of Cell Signaling.	Angew Chem Int Ed Engl	2025	https://conductscience.org/library/papers/40627702	PubMed
40,512,599	Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2.	J Med Chem	2025	https://conductscience.org/library/papers/40512599	PubMed
40,349,346	IRE1α promotes phagosomal calcium flux to enhance macrophage fungicidal activity.	Cell Rep	2025	https://conductscience.org/library/papers/40349346	PubMed
40,177,358	Insights into the effects of apelin-13 on renal function and NHE3 activity following ischemia/reperfusion-induced acute kidney injury.	Front Physiol	2025	https://conductscience.org/library/papers/40177358	PubMed
40,161,402	Effects of extracellular metabolic acidosis on the homeostasis of intracellular pH in hippocampal neurons.	Front Physiol	2024	https://conductscience.org/library/papers/40161402	PubMed

1 to 10 of 321

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Genes0

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None in this release.

Drugs0

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None in this release.

Data0

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None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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