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Paper · 1546953

Li+ increases accumulation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in cholinergically stimulated brain cortex slices in guinea pig, mouse and rat. The increases require inositol supplementation in mouse and rat but not in guinea pig.

Lee CH and 5 others. Biochem J, 1992. Cited by 54 papers, by iCite.

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ConductScience Library. Li+ increases accumulation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in cholinergically stimulated brain cortex slices in guinea pig, mouse and rat. The increases require inositol supplementation in mouse and rat but not in guinea pig. Papers, record 1546953. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/1546953

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Li+ increases accumulation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in cholinergically stimulated brain cortex slices in guinea pig, mouse and rat. The increases require inositol supplementation in mouse and rat but not in guinea pig.
PubMed
Journal
Biochem J
PubMed
Year
1992
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
54
iCite
Relative citation ratio, by iCite
1.7
iCite
Revised in PubMed
2019-05-01
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Lee CHC H
2Dixon JFJ F
3Reichman MM
4Moummi CC
5Los GG
6Hokin LEL E

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cerebral CortexMajor topic
Inositol 1,4,5-TrisphosphateMajor topic
Inositol PhosphatesMajor topic
LithiumMajor topic
Animals
Cations
Chromatography, High Pressure Liquid
Cytidine Diphosphate Diglycerides
Guinea Pigs
In Vitro Techniques
Mice
Rats
Species Specificity

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
DA03699NIDA NIH HHSUnited StatesR01DA003699PubMed and NIHNIH RePORTER
HL16318NHLBI NIH HHSUnited StatesR01HL016318PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References47

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
12,012,613Characterization of inositol 1,4,5-trisphosphate- and inositol 1,3,4,5-tetrakisphosphate-binding sites in rat cerebellum.Biochem J1991https://conductscience.org/library/papers/2012613PubMed
23,426,564Lithium inhibits muscarinic-receptor-stimulated inositol tetrakisphosphate accumulation in rat cerebral cortex.Biochem J1987https://conductscience.org/library/papers/3426564PubMed
33,496,884Inositol(1,3,4,5)tetrakisphosphate-induced activation of sea urchin eggs requires the presence of inositol trisphosphate.Biochem Biophys Res Commun1987https://conductscience.org/library/papers/3496884PubMed
46,323,632Inositol phospholipid hydrolysis in rat cerebral cortical slices: I. Receptor characterisation.J Neurochem1984https://conductscience.org/library/papers/6323632PubMed
51,849,645Inositol 1,3,4,5-tetrakisphosphate and inositol hexakisphosphate receptor proteins: isolation and characterization from rat brain.Proc Natl Acad Sci U S A1991https://conductscience.org/library/papers/1849645PubMed
62,163,607Inositol 1,3,4,5-tetrakisphosphate stimulates calcium release from bovine adrenal microsomes by a mechanism independent of the inositol 1,4,5-trisphosphate receptor.Biochem J1990https://conductscience.org/library/papers/2163607PubMed
72,241,931Synergistic control of Ca2+ mobilization in permeabilized mouse L1210 lymphoma cells by inositol 2,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate.Biochem J1990https://conductscience.org/library/papers/2241931PubMed
82,339,988Reduced inositol polyphosphate accumulation and inositol supply induced by lithium in stimulated cerebral cortex slices.Biochem J1990https://conductscience.org/library/papers/2339988PubMed
92,455,713Kinetics of inositol 1,4,5-trisphosphate and inositol cyclic 1:2,4,5-trisphosphate metabolism in intact rat parotid acinar cells. Relationship to calcium signalling.J Biol Chem1988https://conductscience.org/library/papers/2455713PubMed
102,550,275A novel, specific binding protein assay for quantitation of intracellular inositol 1,3,4,5-tetrakisphosphate (InsP4) using a high-affinity InsP4 receptor from cerebellum.FEBS Lett1989https://conductscience.org/library/papers/2550275PubMed

1 to 10 of 47

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Cited by15

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 54 citations.

PMIDTitleJournalYearIn PapersSource
41,471,339At 75 Years, Is Lithium the Gold Standard in Bipolar Disorder?Pharmaceuticals (Basel)2025https://conductscience.org/library/papers/41471339PubMed
31,411,948Case Studies in Neuroscience: Lack of inhibitory synaptic plasticity in the substantia nigra pars reticulata of a patient with lithium-induced tremor.J Neurophysiol2019https://conductscience.org/library/papers/31411948PubMed
27,922,641IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes.Transl Psychiatry2016https://conductscience.org/library/papers/27922641PubMed
23,344,554The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test.Psychopharmacology (Berl)2013https://conductscience.org/library/papers/23344554PubMed
15,558,078Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited.Mol Psychiatry2005https://conductscience.org/library/papers/15558078PubMed
12,670,128Effects of dextroamphetamine, lithium chloride, sodium valproate and carbamazepine on intraplatelet Ca2+ levels.J Psychiatry Neurosci2003https://conductscience.org/library/papers/12670128PubMed
9,653,192Lithium acutely inhibits and chronically up-regulates and stabilizes glutamate uptake by presynaptic nerve endings in mouse cerebral cortex.Proc Natl Acad Sci U S A1998https://conductscience.org/library/papers/9653192PubMed
9,114,064
The antibipolar drug valproate mimics lithium in stimulating glutamate release and inositol 1,4,5-trisphosphate accumulation in brain cortex slices but not accumulation of inositol monophosphates and bisphosphates.
Proc Natl Acad Sci U S A1997https://conductscience.org/library/papers/9114064PubMed
8,308,733Membrane potential modulates inositol 1,4,5-trisphosphate-mediated Ca2+ transients in guinea-pig coronary myocytes.J Physiol1993https://conductscience.org/library/papers/8308733PubMed
8,242,255Characterization of the effects of lithium on phosphatidylinositol (PI) cycle activity in human muscarinic m1 receptor-transfected CHO cells.Br J Pharmacol1993https://conductscience.org/library/papers/8242255PubMed

1 to 10 of 15

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Genes0

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None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

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None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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