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Paper · 16017

Different sensitivity of DNA in situ in interphase and metaphase chromatin to heat denaturation.

Darzynkiewicz Z and 3 others. J Cell Biol, 1977. Cited by 48 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Different sensitivity of DNA in situ in interphase and metaphase chromatin to heat denaturation. Papers, record 16017. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/16017

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Different sensitivity of DNA in situ in interphase and metaphase chromatin to heat denaturation.
PubMed
Journal
J Cell Biol
PubMed
Year
1977
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
48
iCite
Relative citation ratio, by iCite
1.19
iCite
Revised in PubMed
2019-05-08
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Darzynkiewicz ZZ
2Traganos FF
3Sharpless TT
4Melamed MRM R

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cell DivisionMajor topic
ChromatinMajor topic
DNAMajor topic
Nucleic Acid DenaturationMajor topic
Cell Line
Formaldehyde
Hot Temperature
Hydrogen-Ion Concentration
Magnesium
Mitosis
Osmolar Concentration

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References26

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,122,278Association of tissue-specific histones with deoxyribonucleic acid. Thermal denaturation of native, partially dehistonized, and reconstituted chromatins.Biochemistry1975https://conductscience.org/library/papers/1122278PubMed
21,123,346Chromatin changes during the cell cycle of HeHa cells.J Biol Chem1975https://conductscience.org/library/papers/1123346PubMed
31,145,202Nuclear protein matrix: association with newly synthesized DNA.Science1975https://conductscience.org/library/papers/1145202PubMed
41,249,122Template activity of unfixed metaphase chromosomes.J Cell Sci1976https://conductscience.org/library/papers/1249122PubMed
51,254,935Cytofluorometric studies on conformation of nucleic acids in situ. II. Denaturation of deoxyribonucleic acid.J Histochem Cytochem1976https://conductscience.org/library/papers/1254935PubMed
613,929,834The structure of the DNA-acridine complex.Proc Natl Acad Sci U S A1963https://conductscience.org/library/papers/13929834PubMed
716,590,488AGGREGATION OF DYES BOUND TO POLYANIONS.Proc Natl Acad Sci U S A1959https://conductscience.org/library/papers/16590488PubMed
8239,052Denaturation of deoxyribonucleic acid in situ effect of formaldehyde.J Histochem Cytochem1975https://conductscience.org/library/papers/239052PubMed
94,108,045Alterations of deoxyribonucleoprotein thermal stability induced by lymphocyte-Ehrlich ascites tumor cell interactions.Exp Cell Res1971https://conductscience.org/library/papers/4108045PubMed
104,110,309Cytochemical evidence of nucleoprotein changes in rat adrenal cortex following hypophysectomy or dexamethasone suppression.Exp Cell Res1972https://conductscience.org/library/papers/4110309PubMed

1 to 10 of 26

See all 26 references

Cited by10

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 48 citations.

PMIDTitleJournalYearIn PapersSource
28,780,638Discrimination of Adsorbed Double-Stranded and Single-Stranded DNA Molecules on Surfaces by Fluorescence Emission Spectroscopy Using Acridine Orange Dye.J Fluoresc2017https://conductscience.org/library/papers/28780638PubMed
21,722,802Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry.Methods Cell Biol2011https://conductscience.org/library/papers/21722802PubMed
17,594,478ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke.BMC Cell Biol2007https://conductscience.org/library/papers/17594478PubMed
16,940,754Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants.Cell Cycle2006https://conductscience.org/library/papers/16940754PubMed
16,098,182Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis.Cell Prolif2005https://conductscience.org/library/papers/16098182PubMed
3,653,079Nuclei act as independent and integrated units of replication in a Xenopus cell-free DNA replication system.EMBO J1987https://conductscience.org/library/papers/3653079PubMed
2,424,870Different instability of nuclear DNA at acid hydrolysis in cancerous and noncancerous cells as revealed by fluorescent staining with acridine orange.Histochemistry1986https://conductscience.org/library/papers/2424870PubMed
739,980Comparative properties of rat liver chromatin in situ and in vitro at early stages after partial hepatectomy.Mol Biol Rep1978https://conductscience.org/library/papers/739980PubMed
262,382DNA damage in synchronized HeLa cells irradiated with ultraviolet.Biophys J1979https://conductscience.org/library/papers/262382PubMed
74,309Differential staining of Chironomus thummi giant chromosomes by treatment with acridine orange after mild acid hydrolysis.Chromosoma1977https://conductscience.org/library/papers/74309PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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