Paper · 165259

Dissociation between mitogenicity and immunogenicity of TNP-lipopolysaccharide, a T-independent antigen.

Jacobs MD and 1 other. J Exp Med, 1975. Cited by 94 papers, by iCite.

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ConductScience Library. Dissociation between mitogenicity and immunogenicity of TNP-lipopolysaccharide, a T-independent antigen. Papers, record 165259. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/165259

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Dissociation between mitogenicity and immunogenicity of TNP-lipopolysaccharide, a T-independent antigen.; PubMed
Journal: J Exp Med; PubMed
Year: 1975; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/165259/; PubMed
DOI: https://doi.org/10.1084/jem.141.6.1453; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2189863/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 94; iCite
Relative citation ratio, by iCite: 2.82; iCite
Revised in PubMed: 2019-05-08; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Jacobs MD	M D
2	Morrison DC	D C

Source PubMed

Topics20

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Antigens	Major topic
Lipopolysaccharides	Major topic
Mitogens	Major topic
Nitrobenzenes	Major topic
Animals
B-Lymphocytes
Binding Sites, Antibody
Centrifugation, Isopycnic
Concanavalin A
Haptens
Hemolytic Plaque Technique
Lectins
Mice
Mice, Inbred CBA
Mice, Inbred Strains
Mice, Nude
Mitosis
Polymyxins
Spleen
T-Lymphocytes

Source PubMed

Grants0

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None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References16

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	1,089,715	Suppression and enhancement of the T cell-dependent production of antibody to SRBC in vitro by bacterial lipopolysaccharide.	J Immunol	1975	https://conductscience.org/library/papers/1089715	PubMed
2	1,089,717	Functional heterogeneity among the T-derived lymphocytes of the mouse. II. Sensitivity of subpopulations to anti-thymocyte serum.	J Immunol	1975	https://conductscience.org/library/papers/1089717	PubMed
3	1,090,653	Stimulation of a T-independent primary anti-hapten response in vitro by TNP-lipopolysaccharide (TNP-LPS).	J Immunol	1975	https://conductscience.org/library/papers/1090653	PubMed
4	1,090,654	Effects of concanavalin A on the in vitro responses of mouse spleen cells to T-dependent and T-independent antigens.	J Immunol	1975	https://conductscience.org/library/papers/1090654	PubMed
5	4,104,294	The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response.	J Exp Med	1971	https://conductscience.org/library/papers/4104294	PubMed
6	4,125,593	B cell mitogenic properties of thymus-independent antigens.	Nat New Biol	1973	https://conductscience.org/library/papers/4125593	PubMed
7	4,128,449	Mechanism of thymus-independent immunocyte triggering. Mitogenic activation of B cells results in specific immune responses.	J Exp Med	1974	https://conductscience.org/library/papers/4128449	PubMed
8	4,148,779	Mitogenic properties of the thymus-independent antigen pneumococcal polysaccharide S3.	Eur J Immunol	1973	https://conductscience.org/library/papers/4148779	PubMed
9	4,288,800	Neutralization of endotoxin toxicity in chick embryos by antibiotics.	J Bacteriol	1966	https://conductscience.org/library/papers/4288800	PubMed
10	4,291,769	Prevention by polymyxin B of endotoxin lethality in mice.	J Bacteriol	1967	https://conductscience.org/library/papers/4291769	PubMed

1 to 10 of 16

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Cited by35

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 94 citations.

PMID	Title	Journal	Year	In Papers	Source
42,544,498	PPE18 protein of Mycobacterium tuberculosis downregulates LPS-induced IgG production by inhibiting nitric oxide synthesis.	J Biosci	2026	https://conductscience.org/library/papers/42544498	PubMed
17,346,284	Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill.	Immunology	2007	https://conductscience.org/library/papers/17346284	PubMed
8,418,211	Assessment of ability of murine and human anti-lipid A monoclonal antibodies to bind and neutralize lipopolysaccharide.	J Exp Med	1993	https://conductscience.org/library/papers/8418211	PubMed
8,132,348	Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity.	Infect Immun	1994	https://conductscience.org/library/papers/8132348	PubMed
7,007,214	In vitro and in vivo response of lymphoid cells from LHC hamsters to murine thymus-independent and thymus-dependent antigens.	Immunology	1980	https://conductscience.org/library/papers/7007214	PubMed
6,971,262	Dissociation of the anti-hapten and anti-carrier responses of mice injected with dinitrophenylated lipopolysaccharide.	Infect Immun	1981	https://conductscience.org/library/papers/6971262	PubMed
6,715,043	Mitogenic activities of synthetic lipid A analogs and suppression of mitogenicity of lipid A.	Infect Immun	1984	https://conductscience.org/library/papers/6715043	PubMed
6,348,772	Molecular requirements for B-lymphocyte activation by Escherichia coli lipopolysaccharide.	Proc Natl Acad Sci U S A	1983	https://conductscience.org/library/papers/6348772	PubMed
6,266,967	Polymyxin B inactivation of lipopolysaccharide in vaccines of Gram-negative bacteria.	Infect Immun	1981	https://conductscience.org/library/papers/6266967	PubMed
6,199,303	Lipid A and resistance of Salmonella typhimurium to antimicrobial granule proteins of human neutrophil granulocytes.	Infect Immun	1984	https://conductscience.org/library/papers/6199303	PubMed

1 to 10 of 35

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None in this release.

Drugs0

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None in this release.

Data0

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Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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