Paper · 166160

The distribution of acetylcholine sensitivity at the post-synaptic membrane of vertebrate skeletal twitch muscles: iontophoretic mapping in the micron range.

Kuffler SW and 1 other. J Physiol, 1975. Cited by 180 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. The distribution of acetylcholine sensitivity at the post-synaptic membrane of vertebrate skeletal twitch muscles: iontophoretic mapping in the micron range. Papers, record 166160. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/166160

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The distribution of acetylcholine sensitivity at the post-synaptic membrane of vertebrate skeletal twitch muscles: iontophoretic mapping in the micron range.; PubMed
Journal: J Physiol; PubMed
Year: 1975; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/166160/; PubMed
DOI: https://doi.org/10.1113/jphysiol.1975.sp010821; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC1330831/; PubMed
The journal: https://conductscience.org/library/journal-index/0266262; PubMed
Citations, by iCite: 180; iCite
Relative citation ratio, by iCite: 4.86; iCite
Revised in PubMed: 2025-01-03; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Kuffler SW	S W
2	Yoshikami D	D

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Acetylcholine	Major topic
Muscles	Major topic
Synaptic Membranes	Major topic
Acetylcholinesterase
Animals
Dose-Response Relationship, Drug
Iontophoresis
Membrane Potentials
Microbial Collagenase
Microelectrodes
Microscopy, Electron
Neuromuscular Junction
Rana pipiens
Snakes
Caudata

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References34

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
2	14,422,355	Junctional and extra-junctional acetylcholine receptors in skeletal muscle fibres.	J Physiol	1960	https://conductscience.org/library/papers/14422355	PubMed
3	14,422,356	The acetylcholine sensitivity of frog muscle fibres after complete or partial devervation.	J Physiol	1960	https://conductscience.org/library/papers/14422356	PubMed
5	166,159	Increased extrajunctional acetylcholine sensitivity produced by chronic acetylcholine sensitivity produced by chronic post-synaptic neuromuscular blockade.	J Physiol	1975	https://conductscience.org/library/papers/166159	PubMed
9	4,133,039	Fluorescent staining of acetylcholine receptors in vertebrate skeletal muscle.	J Physiol	1974	https://conductscience.org/library/papers/4133039	PubMed
10	4,243,789	Responses of snake muscle spindles to stretch and intrafusal muscle fiber contraction.	J Neurophysiol	1970	https://conductscience.org/library/papers/4243789	PubMed
11	4,331,819	Ionic permeability changes induced by some cholinergic agonists on normal and denervated frog muscles.	J Physiol	1971	https://conductscience.org/library/papers/4331819	PubMed
12	4,336,524	Control of ACh sensitivity by muscle activity in the rat.	J Physiol	1972	https://conductscience.org/library/papers/4336524	PubMed
13	4,348,786	Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junction.	J Cell Biol	1973	https://conductscience.org/library/papers/4348786	PubMed
14	4,348,791	Turnover of transmitter and synaptic vesicles at the frog neuromuscular junction.	J Cell Biol	1973	https://conductscience.org/library/papers/4348791	PubMed
15	4,352,108	Effects of proteolytic enzymes on function and structure of frog neuromuscular junctions.	J Physiol	1973	https://conductscience.org/library/papers/4352108	PubMed

1 to 10 of 34

See all 34 references

Cited by74

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 180 citations.

PMID	Title	Journal	Year	In Papers	Source
32,245,200	αM-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish.	Toxins (Basel)	2020	https://conductscience.org/library/papers/32245200	PubMed
27,281,175	Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment.	Curr Neuropharmacol	2017	https://conductscience.org/library/papers/27281175	PubMed
25,505,495	Protein dynamics and the allosteric transitions of pentameric receptor channels.	Biophys Rev	2014	https://conductscience.org/library/papers/25505495	PubMed
25,210,157	New insights into short-term synaptic facilitation at the frog neuromuscular junction.	J Neurophysiol	2015	https://conductscience.org/library/papers/25210157	PubMed
23,717,646	Functional expression of human α9* nicotinic acetylcholine receptors in X. laevis oocytes is dependent on the α9 subunit 5' UTR.	PLoS One	2013	https://conductscience.org/library/papers/23717646	PubMed
22,969,726	Extrasynaptic exocytosis and its mechanisms: a source of molecules mediating volume transmission in the nervous system.	Front Physiol	2012	https://conductscience.org/library/papers/22969726	PubMed
15,649,983	Na+-K+ pump stimulation restores carbacholine-induced loss of excitability and contractility in rat skeletal muscle.	J Physiol	2005	https://conductscience.org/library/papers/15649983	PubMed
10,804,208	From plaque to pretzel: fold formation and acetylcholine receptor loss at the developing neuromuscular junction.	J Neurosci	2000	https://conductscience.org/library/papers/10804208	PubMed
8,594,541	Interaction of Na+ and Mg2+ ions in acetylcholine receptor channels of frog skeletal muscle changes in character with an increase in agonist concentration.	Pflugers Arch	1995	https://conductscience.org/library/papers/8594541	PubMed
7,624,348	Amperometric detection of stimulus-induced quantal release of catecholamines from cultured superior cervical ganglion neurons.	Proc Natl Acad Sci U S A	1995	https://conductscience.org/library/papers/7624348	PubMed

1 to 10 of 74

See all 74 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
ACHE	43	PubTator's text mining	https://conductscience.org/library/genes/43

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/166160

GET https://conductscience.org/api/papers/v1/166160/references?page=2

API reference For AI assistants