Paper · 167289

IMP dehydrogenase, an enzyme linked with proliferation and malignancy.

Jackson RC and 2 others. Nature, 1975. Cited by 369 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. IMP dehydrogenase, an enzyme linked with proliferation and malignancy. Papers, record 167289. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/167289

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: IMP dehydrogenase, an enzyme linked with proliferation and malignancy.; PubMed
Journal: Nature; PubMed
Year: 1975; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/167289/; PubMed
DOI: https://doi.org/10.1038/256331a0; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 369; iCite
Relative citation ratio, by iCite: 7.48; iCite
Revised in PubMed: 2019-06-17; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Jackson RC	R C
2	Weber G	G
3	Morris HP	H P

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Carcinoma, Hepatocellular	Major topic
IMP Dehydrogenase	Major topic
Ketone Oxidoreductases	Major topic
Liver	Major topic
Liver Neoplasms	Major topic
Animals
Cell Division
Kinetics
Liver Regeneration
Rats

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

Trial	Title	The trial lists it as	Named in the paper's record
NCT00923728	A Phase I Trial of AVN944, an IMPDH Inhibitor, in Adults With Advanced Stage Solid Tumors	Background

Source ClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by96

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 369 citations.

PMID	Title	Journal	Year	In Papers	Source
42,549,980	Inosine monophosphate dehydrogenases are key players for functional development in Arabidopsis.	Plant J	2026	https://conductscience.org/library/papers/42549980	PubMed
42,334,544	Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.	Adv Exp Med Biol	2026	https://conductscience.org/library/papers/42334544	PubMed
41,826,336	Enterocytes rely on purine biosynthesis/salvage pathway to facilitate dietary fat absorption.	Nat Commun	2026	https://conductscience.org/library/papers/41826336	PubMed
41,494,804	Integrated screens reveal that guanine nucleotide depletion, which is irreversible via targeting IMPDH2, inhibits pancreatic cancer and potentiates KRAS inhibition.	Gut	2026	https://conductscience.org/library/papers/41494804	PubMed
41,130,734	Unimodal Imaging of Monovalent Metal-Chelator Complexes and Lipids by MALDI Imaging Mass Spectrometry.	J Am Soc Mass Spectrom	2025	https://conductscience.org/library/papers/41130734	PubMed
39,470,689	IMPA1-derived inositol maintains stemness in castration-resistant prostate cancer via IMPDH2 activation.	J Exp Med	2024	https://conductscience.org/library/papers/39470689	PubMed
38,940,616	Live-cell analysis of IMPDH protein levels during yeast colony growth provides insights into the regulation of GTP synthesis.	mBio	2024	https://conductscience.org/library/papers/38940616	PubMed
38,743,184	Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012-2023).	Nat Prod Bioprospect	2024	https://conductscience.org/library/papers/38743184	PubMed
38,323,936	Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly.	J Cell Biol	2024	https://conductscience.org/library/papers/38323936	PubMed
38,310,229	Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer.	J Transl Med	2024	https://conductscience.org/library/papers/38310229	PubMed

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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