Paper16939

Studies on the pathogenesis of an immune defect in multiple myeloma.

Paglieroni T and 1 other. J Clin Invest, 1977. Cited by 84 papers, by iCite.

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ConductScience Library. Studies on the pathogenesis of an immune defect in multiple myeloma. Papers, record 16939. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/16939

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Studies on the pathogenesis of an immune defect in multiple myeloma.; PubMed
Journal: J Clin Invest; PubMed
Year: 1977; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/16939/; PubMed
DOI: https://doi.org/10.1172/jci108736; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC372325/; PubMed
The journal: https://conductscience.org/library/journal-index/7802877; PubMed
Citations, by iCite: 84; iCite
Relative citation ratio, by iCite: 2.54; iCite
Revised in PubMed: 2018-11-13; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Paglieroni T	T
2	MacKenzie MR	M R

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Antigens	Major topic
Immunologic Deficiency Syndromes	Major topic
Lymphocytes	Major topic
Multiple Myeloma	Major topic
Adult
Aged
B-Lymphocytes
Binding Sites, Antibody
Humans
Immunoglobulin G
Immunoglobulin M
Lectins
Middle Aged
Mitomycins
Polysaccharides, Bacterial
Streptococcus pneumoniae
T-Lymphocytes
Tetanus Toxoid

Source PubMed

Show 12 more topicsShow fewer topics

References27

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	1,080,834	Impaired synthesis of polyclonal (non-paraprotein) immunoglobulins by circulating lymphocytes from patients with multiple myeloma Role of suppressor cells.	N Engl J Med	1975	https://conductscience.org/library/papers/1080834	PubMed
2	1,083,758	Letter: Suppressor cells and human malignant disease.	Br Med J	1976	https://conductscience.org/library/papers/1083758	PubMed
3	1,084,353	Suppression of B-cell differentiation by leukocytes from hypogammaglobulinemic patients.	J Clin Invest	1976	https://conductscience.org/library/papers/1084353	PubMed
4	1,179,167	Identification of cells with monocyte markers in panhypogammaglobulinaemia.	Scand J Immunol	1975	https://conductscience.org/library/papers/1179167	PubMed
5	1,191,549	Phagocytes and C4 in paraproteinaemia.	Br J Haematol	1975	https://conductscience.org/library/papers/1191549	PubMed
6	123,545	Suppressor cells in tumor-bearing mice capable of nonspecific blocking of in vitro immunization against transplant antigens.	J Immunol	1975	https://conductscience.org/library/papers/123545	PubMed
7	125,290	Hodgkin's disease. An immunodepleting and immunosuppressive disorder.	J Clin Invest	1975	https://conductscience.org/library/papers/125290	PubMed
8	131,175	Suppressor cell activity after concanavalin A treatment of lymphocytes from normal donors.	J Exp Med	1976	https://conductscience.org/library/papers/131175	PubMed
9	14,234,820	IMMUNOLOGICAL DEFICIENCY DISORDERS ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA AND MULTIPLE MYELOMA.	J Clin Invest	1964	https://conductscience.org/library/papers/14234820	PubMed
10	4,099,713	Immunoglobulins on the surface of lymphocytes. I. Distribution and quantitation.	J Exp Med	1971	https://conductscience.org/library/papers/4099713	PubMed
11	4,137,918	Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia.	Lancet	1974	https://conductscience.org/library/papers/4137918	PubMed
12	4,361,978	Immunity to murine sarcoma virus-inducted tumors. II. Suppression of T cell-mediated immunity by cells from progressor animals.	J Immunol	1974	https://conductscience.org/library/papers/4361978	PubMed
13	4,541,574	Binding of sheep erythrocytes to human lymphocytes. A probable marker of T lymphocytes.	Scand J Immunol	1972	https://conductscience.org/library/papers/4541574	PubMed
14	4,544,194	Purification of human T and B lymphocytes.	J Immunol	1974	https://conductscience.org/library/papers/4544194	PubMed
15	4,546,531	Human lymphocytes with receptors for IgG. A population of cells distinct from T- and B-lymphocytes.	Int Arch Allergy Appl Immunol	1974	https://conductscience.org/library/papers/4546531	PubMed
16	4,547,576	Humoral immunosuppressive substance in mice bearing plasmacytomas.	Science	1974	https://conductscience.org/library/papers/4547576	PubMed
17	4,598,016	Evidence of suppressor cell activity in spleens of mice bearing primary tumors induced by Moloney sarcoma virus.	J Exp Med	1974	https://conductscience.org/library/papers/4598016	PubMed
18	4,616,765	In vitro conversion of normal mouse lymphocytes by plasmacytoma RNA to express idiotypic specificities on their surface characteristic of the plasmacytoma immunoglobulin.	Cell Immunol	1974	https://conductscience.org/library/papers/4616765	PubMed
19	4,775,047	A rapid microtechnique for in vitro stimulation of human lymphocytes by phytohemagglutinin.	Clin Immunol Immunopathol	1973	https://conductscience.org/library/papers/4775047	PubMed
20	4,825,786	Cellular basis of immunodepression in mice with plasmacytomas.	J Immunol	1974	https://conductscience.org/library/papers/4825786	PubMed

Show 14 more referencesShow fewer referencesSee all 27 references

Cited by17

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 84 citations.

PMID	Title	Journal	Year	In Papers	Source
7,529,259	Autoregulatory circuits in myeloma. Tumor cell cytotoxicity mediated by soluble CD16.	J Clin Invest	1995	https://conductscience.org/library/papers/7529259	PubMed
7,047,886	PWM-induced generation of immunoglobulin-secreting cells in patients with multiple myeloma.	Klin Wochenschr	1981	https://conductscience.org/library/papers/7047886	PubMed
6,604,067	T-cell imbalances in patients with multiple myeloma: an analysis by monoclonal antibodies.	J Clin Immunol	1983	https://conductscience.org/library/papers/6604067	PubMed
6,461,449	The mode of action of splenic suppressor cells in murine plasmacytoma.	Clin Exp Immunol	1981	https://conductscience.org/library/papers/6461449	PubMed
6,451,635	Immunoregulatory T cell function in multiple myeloma.	J Clin Invest	1981	https://conductscience.org/library/papers/6451635	PubMed
6,444,638	Diminished synthesis of immunoglobulin by peripheral lymphocytes of patients with idiopathic membranous glomerulonephropathy.	J Clin Invest	1980	https://conductscience.org/library/papers/6444638	PubMed
6,331,877	Imbalances of T-cell subsets in monoclonal gammopathies.	Cancer Immunol Immunother	1984	https://conductscience.org/library/papers/6331877	PubMed
6,235,070	Membrane phenotype and functional behaviour of T lymphocytes in multiple myeloma: correlation with clinical stages of the disease.	Clin Exp Immunol	1984	https://conductscience.org/library/papers/6235070	PubMed
6,212,173	Immunosuppression in plasmacytoma: induction of suppressor cells.	Clin Exp Immunol	1982	https://conductscience.org/library/papers/6212173	PubMed
3,023,434	Humoral immune deficiency in multiple myeloma patients due to compromised B-cell function.	J Clin Immunol	1986	https://conductscience.org/library/papers/3023434	PubMed
2,995,434	Specificity repertoire of lymphocytes from multiple myeloma patients. I. High frequency of B cells specific for idiotypic and F(ab')2-region determinants on immunoglobulin.	J Clin Immunol	1985	https://conductscience.org/library/papers/2995434	PubMed
2,613,329	Protracted necrotizing pharyngitis associated with an acquired defect of neutrophil chemotaxis in multiple myeloma.	Infection	1989	https://conductscience.org/library/papers/2613329	PubMed
2,289,214	The effect of ranitidine on cellular immunity in patients with multiple myeloma.	Cancer Immunol Immunother	1990	https://conductscience.org/library/papers/2289214	PubMed
2,044,221	A disturbance of the IL-2/IL-2 receptor system parallels the activity of multiple myeloma.	Clin Exp Immunol	1991	https://conductscience.org/library/papers/2044221	PubMed
391,824	Mechanisms in secondary hypogammaglobulinaemia.	J Clin Pathol Suppl (R Coll Pathol)	1979	https://conductscience.org/library/papers/391824	PubMed
311,781	Immunoregulation in humans: control of antitetanus toxoid antibody production after booster immunization.	J Clin Invest	1978	https://conductscience.org/library/papers/311781	PubMed
307,968	The mechanism of the immunologic deficiency in myeloma of man and mouse.	Blut	1978	https://conductscience.org/library/papers/307968	PubMed

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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