Paper · 1728060

Modification of intracellular pH and thermosensitivity.

Lyons JC and 2 others. Radiat Res, 1992. Cited by 54 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Modification of intracellular pH and thermosensitivity. Papers, record 1728060. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/1728060

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Modification of intracellular pH and thermosensitivity.; PubMed
Journal: Radiat Res; PubMed
Year: 1992; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/1728060/; PubMed
The journal: https://conductscience.org/library/journal-index/0401245; PubMed
Citations, by iCite: 54; iCite
Relative citation ratio, by iCite: 1.98; iCite
Revised in PubMed: 2014-11-20; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Lyons JC	J C
2	Kim GE	G E
3	Song CW	C W

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid	Major topic
Adaptation, Physiological	Major topic
Amiloride	Major topic
Hot Temperature	Major topic
Hydrogen-Ion Concentration	Major topic
Nigericin	Major topic
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
Adenocarcinoma
Animals
Cell Line
In Vitro Techniques
Mammary Neoplasms, Animal
Mice

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
CA13353	NCI NIH HHS	United States	R01CA013353	PubMed and NIH	NIH RePORTER
CA44114	NCI NIH HHS	United States	R01CA044114	PubMed and NIH	NIH RePORTER
			R37CA013353	NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by9

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 54 citations.

PMID	Title	Journal	Year	In Papers	Source
41,778,592	SLC4A1 mutations that cause distal renal tubular acidosis alter cytoplasmic pH and cellular autophagy.	Elife	2026	https://conductscience.org/library/papers/41778592	PubMed
35,541,713	Manipulating extracellular tumour pH: an effective target for cancer therapy.	RSC Adv	2018	https://conductscience.org/library/papers/35541713	PubMed
27,613,534	Topiramate induces acute intracellular acidification in glioblastoma.	J Neurooncol	2016	https://conductscience.org/library/papers/27613534	PubMed
27,497,601	Mechanism of antineoplastic activity of lonidamine.	Biochim Biophys Acta	2016	https://conductscience.org/library/papers/27497601	PubMed
22,745,015	(31) P and (1) H MRS of DB-1 melanoma xenografts: lonidamine selectively decreases tumor intracellular pH and energy status and sensitizes tumors to melphalan.	NMR Biomed	2013	https://conductscience.org/library/papers/22745015	PubMed
9,525,814	Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification.	J Neurooncol	1998	https://conductscience.org/library/papers/9525814	PubMed
8,641,385	Accumulation of purine catabolites in solid tumors exposed to therapeutic hyperthermia.	Experientia	1996	https://conductscience.org/library/papers/8641385	PubMed
8,411,117	Rapid increase in pH set-point of the Na(+)-in-dependent chloride/bicarbonate antiporter in Vero cells exposed to heat shock.	J Membr Biol	1993	https://conductscience.org/library/papers/8411117	PubMed
8,217,605	Regulation of intracellular pH in subpopulations of cells derived from spheroids and solid tumours.	Br J Cancer	1993	https://conductscience.org/library/papers/8217605	PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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