Paper · 17524378

Maternal microchimerism leads to the presence of interleukin-2 in interleukin-2 knock out mice: implications for the role of interleukin-2 in thymic function.

Wrenshall LE and 3 others. Cell Immunol, 2007. Cited by 22 papers, by iCite.

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ConductScience Library. Maternal microchimerism leads to the presence of interleukin-2 in interleukin-2 knock out mice: implications for the role of interleukin-2 in thymic function. Papers, record 17524378. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/17524378

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Maternal microchimerism leads to the presence of interleukin-2 in interleukin-2 knock out mice: implications for the role of interleukin-2 in thymic function.; PubMed
Journal: Cell Immunol; PubMed
Year: 2007; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/17524378/; PubMed
DOI: https://doi.org/10.1016/j.cellimm.2007.04.002; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC1950576/; PubMed
The journal: https://conductscience.org/library/journal-index/1246405; PubMed
Citations, by iCite: 22; iCite
Relative citation ratio, by iCite: 0.46; iCite
Revised in PubMed: 2025-05-29; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Wrenshall LE	Lucile E
2	Stevens ET	Elliot T
3	Smith DR	Deandra R
4	Miller JD	John D

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Chimerism	Major topic
Interleukin-2	Major topic
Thymus Gland	Major topic
Animals
Cell Differentiation
Cell Survival
Female
Homeodomain Proteins
Immunophenotyping
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Maternal-Fetal Exchange
Mice
Mice, Knockout
Mice, Transgenic
Organ Specificity
Phosphorylation
Pregnancy
T-Lymphocytes

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
R01 AI047825	NIAID NIH HHS	United States	R01AI047825	PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References45

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	10,725,235	Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets.	Development	2000	https://conductscience.org/library/papers/10725235	PubMed
2	7,770,771	Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta.	Science	1995	https://conductscience.org/library/papers/7770771	PubMed
3	10,882,422	Thymic vasculature: organizer of the medullary epithelial compartment?	Int Immunol	2000	https://conductscience.org/library/papers/10882422	PubMed
4	11,122,462	Two independent pathways of maternal cell transmission to offspring: through placenta during pregnancy and by breast-feeding after birth.	Immunology	2000	https://conductscience.org/library/papers/11122462	PubMed
5	11,145,654	Positive and negative selection of thymocytes depends on Lck interaction with the CD4 and CD8 coreceptors.	J Immunol	2001	https://conductscience.org/library/papers/11145654	PubMed
6	11,160,274	Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes.	J Immunol	2001	https://conductscience.org/library/papers/11160274	PubMed
7	11,342,609	A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection.	J Immunol	2001	https://conductscience.org/library/papers/11342609	PubMed
8	11,857,342	Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice.	Eur J Immunol	2002	https://conductscience.org/library/papers/11857342	PubMed
9	11,869,894	New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision.	Curr Opin Immunol	2002	https://conductscience.org/library/papers/11869894	PubMed
10	12,033,737	T-cell development and the CD4-CD8 lineage decision.	Nat Rev Immunol	2002	https://conductscience.org/library/papers/12033737	PubMed

1 to 10 of 45

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Cited by17

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 22 citations.

PMID	Title	Journal	Year	In Papers	Source
42,756,425	Prenatal maternal infection promotes maternal microchimeric cells to alter infection risk in male offspring.	Front Immunol	2026	https://conductscience.org/library/papers/42756425	PubMed
41,897,410	Peripheral Oxidation-Inflammation and Immunosenescence in Triple-Transgenic Mice for Alzheimer's Disease (3xTg-AD) at Early Neuropathological Stages of Disease and Decrease of Immune Impairment by Voluntary Exercise.	Biomolecules	2026	https://conductscience.org/library/papers/41897410	PubMed
41,134,118	Identifying Key Questions and Challenges in Microchimerism Biology.	Adv Sci (Weinh)	2025	https://conductscience.org/library/papers/41134118	PubMed
41,058,380	A mother's touch: microbial guardians of early immune imprinting.	Trends Immunol	2026	https://conductscience.org/library/papers/41058380	PubMed
40,067,465	The when, what, and where of naturally-acquired microchimerism.	Semin Immunopathol	2025	https://conductscience.org/library/papers/40067465	PubMed
39,862,964	Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age.	Mucosal Immunol	2025	https://conductscience.org/library/papers/39862964	PubMed
39,644,358	Clinical relevance of feto-maternal microchimerism in (hematopoietic stem cell) transplantation.	Semin Immunopathol	2024	https://conductscience.org/library/papers/39644358	PubMed
39,027,950	Maternal-Fetal Microchimerism: Impacts on Offspring's Immune Development and Transgenerational Immune Memory Transfer.	Physiol Res	2024	https://conductscience.org/library/papers/39027950	PubMed
38,812,502	IL-2Rα KO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Rα in lymphoid and non-lymphoid cells.	Front Immunol	2024	https://conductscience.org/library/papers/38812502	PubMed
37,575,249	In utero position matters for littermate cell transfer in mice: an additional and confounding source with maternal microchimerism.	Front Immunol	2023	https://conductscience.org/library/papers/37575249	PubMed

1 to 10 of 17

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Genes0

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None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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