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Paper · 17526515

Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool.

Sander JD and 4 others. Nucleic Acids Res, 2007. Cited by 198 papers, by iCite.

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ConductScience Library. Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool. Papers, record 17526515. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/17526515

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool.
PubMed
Journal
Nucleic Acids Res
PubMed
Year
2007
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
Citations, by iCite
198
iCite
Relative citation ratio, by iCite
3.83
iCite
Revised in PubMed
2025-05-29
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Sander JDJeffry D
2Zaback PPeter
3Joung JKJ Keith
4Voytas DFDaniel F
5Dobbs DDrena

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Computational BiologyMajor topic
DNA-Binding ProteinsMajor topic
DeoxyribonucleasesMajor topic
Protein EngineeringMajor topic
SoftwareMajor topic
Transcription FactorsMajor topic
Zinc FingersMajor topic
Binding Sites
Humans
Internet
Protein Conformation
Protein Structure, Secondary
Protein Structure, Tertiary
Sequence Analysis, DNA
User-Computer Interface

Source PubMed

Grants8

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
GM066387NIGMS NIH HHSUnited StatesR21GM066387PubMed and NIHNIH RePORTER
GM0699006NIGMS NIH HHSUnited StatesPubMedPubMed
R01 GM072621NIGMS NIH HHSUnited StatesR01GM072621PubMed and NIHNIH RePORTER
R21 GM066387NIGMS NIH HHSUnited StatesR21GM066387PubMed and NIHNIH RePORTER
R33 GM066387NIGMS NIH HHSUnited StatesR21GM066387PubMed and NIHNIH RePORTER
DP1 OD006862NIH HHSUnited StatesDP1OD006862PubMed and NIHNIH RePORTER
GM072621NIGMS NIH HHSUnited StatesR01GM072621PubMed and NIHNIH RePORTER
R33GM066387NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References27

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
112,592,413Human zinc fingers as building blocks in the construction of artificial transcription factors.Nat Biotechnol2003https://conductscience.org/library/papers/12592413PubMed
212,054,906The use of zinc finger peptides to study the role of specific factor binding sites in the chromatin environment.Methods2002https://conductscience.org/library/papers/12054906PubMed
315,239,882Recent developments in the engineering of zinc finger proteins.Brief Funct Genomic Proteomic2003https://conductscience.org/library/papers/15239882PubMed
48,577,732Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain.Proc Natl Acad Sci U S A1996https://conductscience.org/library/papers/8577732PubMed
510,077,584Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences.Proc Natl Acad Sci U S A1999https://conductscience.org/library/papers/10077584PubMed
615,680,969Towards therapeutic applications of engineered zinc finger proteins.FEBS Lett2005https://conductscience.org/library/papers/15680969PubMed
715,806,097Highly efficient endogenous human gene correction using designed zinc-finger nucleases.Nature2005https://conductscience.org/library/papers/15806097PubMed
816,043,120Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavage.Biochem Biophys Res Commun2005https://conductscience.org/library/papers/16043120PubMed
916,039,907Custom zinc-finger nucleases for use in human cells.Mol Ther2005https://conductscience.org/library/papers/16039907PubMed
1016,107,335Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors.J Biol Chem2005https://conductscience.org/library/papers/16107335PubMed

1 to 10 of 27

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Cited by133

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 198 citations.

PMIDTitleJournalYearIn PapersSource
42,895,683Epigenetics in development, disease, and therapy: from mechanisms to clinical interventions.Sci China Life Sci2026https://conductscience.org/library/papers/42895683PubMed
42,856,188Relaxin-3 neurons of the zebrafish periaqueductal gray mediate behavioral responses evoked by darkness.bioRxiv2026https://conductscience.org/library/papers/42856188PubMed
42,278,539Divergent Roles of Zebrafish IGF1 Receptor a and b in Glucose and Lipid Metabolism.Int J Mol Sci2026https://conductscience.org/library/papers/42278539PubMed
40,539,845Mutant zebrafish lacking slc25a22a show spontaneous seizures and respond to the anti-seizure medication valproic acid.Dis Model Mech2025https://conductscience.org/library/papers/40539845PubMed
40,407,134Insights into the role of Fsh signaling in ovarian differentiation of chorionic gonadotropin α ( cgα)-deficient zebrafish.Zool Res2025https://conductscience.org/library/papers/40407134PubMed
39,963,359Advancements in genome editing tools for genetic studies and crop improvement.Front Plant Sci2024https://conductscience.org/library/papers/39963359PubMed
39,570,288Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis.Elife2024https://conductscience.org/library/papers/39570288PubMed
38,318,375Genetic and chemical disruption of amyloid precursor protein processing impairs zebrafish sleep maintenance.iScience2024https://conductscience.org/library/papers/38318375PubMed
38,020,915CatSper mediates not only chemotactic behavior but also the motility of ascidian sperm.Front Cell Dev Biol2023https://conductscience.org/library/papers/38020915PubMed
37,914,813Genomic disturbance of vitellogenin 2 (vtg2) leads to vitellin membrane deficiencies and significant mortalities at early stages of embryonic development in zebrafish (Danio rerio).Sci Rep2023https://conductscience.org/library/papers/37914813PubMed

1 to 10 of 133

See all 133 cited by

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
TTC41P253,724PubTator's text mininghttps://conductscience.org/library/genes/253724NCBI Gene
ZKSCAN755,888PubTator's text mininghttps://conductscience.org/library/genes/55888NCBI Gene
ZNF27410,782PubTator's text mininghttps://conductscience.org/library/genes/10782NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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