Paper · 17538

In vitro pharmacology of the opioid peptides, enkephalins and endorphins.

Waterfield AA and 4 others. Eur J Pharmacol, 1977. Cited by 216 papers, by iCite.

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ConductScience Library. In vitro pharmacology of the opioid peptides, enkephalins and endorphins. Papers, record 17538. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/17538

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: In vitro pharmacology of the opioid peptides, enkephalins and endorphins.; PubMed
Journal: Eur J Pharmacol; PubMed
Year: 1977; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/17538/; PubMed
DOI: https://doi.org/10.1016/0014-2999(77)90123-6; PubMed
The journal: https://conductscience.org/library/journal-index/1254354; PubMed
Citations, by iCite: 216; iCite
Relative citation ratio, by iCite: 9.45; iCite
Revised in PubMed: 2019-06-23; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Waterfield AA	A A
2	Smokcum RW	R W
3	Hughes J	J
4	Kosterlitz HW	H W
5	Henderson G	G

Source PubMed

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Endorphins	Major topic
Enkephalins	Major topic
Oligopeptides	Major topic
Peptides	Major topic
Animals
Brain
Depression, Chemical
Electric Stimulation
Guinea Pigs
Ileum
In Vitro Techniques
Male
Muscle Contraction
Muscle, Smooth
Naloxone
Neurotransmitter Agents
Peptide Fragments
Synaptic Transmission
Time Factors
Vas Deferens
beta-Lipotropin

Source PubMed

Grants0

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None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by37

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 216 citations.

PMID	Title	Journal	Year	In Papers	Source
18,415,396	[Oral administration of slow-release naloxone for prevention of constipation but not analgesia following oral morphine.].	Schmerz	1993	https://conductscience.org/library/papers/18415396	PubMed
8,799,185	Agonist-selective endocytosis of mu opioid receptor by neurons in vivo.	Proc Natl Acad Sci U S A	1996	https://conductscience.org/library/papers/8799185	PubMed
7,534,650	Irradiation influences the expression of substance P and enkephalin in the rat larynx.	Cell Tissue Res	1995	https://conductscience.org/library/papers/7534650	PubMed
7,470,736	Action of enkephalin analogues and morphine on brain acetylcholine release: differential reversal by naloxone and an opiate pentapeptide.	Br J Pharmacol	1980	https://conductscience.org/library/papers/7470736	PubMed
7,406,864	Isolation, characterization and opiate activity of beta-endorphin from the pituitary gland of the ostrich, Struthio camelus.	Biochem J	1980	https://conductscience.org/library/papers/7406864	PubMed
7,298,381	Enkephalin-immunoreactive nerve fibers in the feline genito-urinary tract.	Histochemistry	1981	https://conductscience.org/library/papers/7298381	PubMed
7,236,987	Evidence for an action of morphine and the enkephalins on sensory nerve endings in the mouse peritoneum.	Br J Pharmacol	1981	https://conductscience.org/library/papers/7236987	PubMed
7,155,202	Differential effects of SKF 10,047 (N-allyl-normetazocine) on peristalsis and longitudinal muscle contractions of the isolated guinea-pig ileum.	Naunyn Schmiedebergs Arch Pharmacol	1982	https://conductscience.org/library/papers/7155202	PubMed
6,772,265	Effects of thyrotrophin-releasing hormone, and methionine-enkephalin on gastric acid and pepsin secretion in the cat.	Br J Pharmacol	1980	https://conductscience.org/library/papers/6772265	PubMed
6,759,496	Enkephalin-like immunoreactivity in the human male genital tract.	J Anat	1982	https://conductscience.org/library/papers/6759496	PubMed

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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