Paper18248

Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors.

Doxey JC and 2 others. Br J Pharmacol, 1977. Cited by 514 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors. Papers, record 18248. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/18248

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors.; PubMed
Journal: Br J Pharmacol; PubMed
Year: 1977; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/18248/; PubMed
DOI: https://doi.org/10.1111/j.1476-5381.1977.tb16752.x; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC1667189/; PubMed
The journal: https://conductscience.org/library/journal-index/7502536; PubMed
Citations, by iCite: 514; iCite
Relative citation ratio, by iCite: 24.9; iCite
Revised in PubMed: 2019-05-09; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Doxey JC	J C
2	Smith CF	C F
3	Walker JM	J M

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Adrenergic alpha-Antagonists	Major topic
Synapses	Major topic
Animals
Clonidine
In Vitro Techniques
Male
Muscle Contraction
Muscle, Smooth
Norepinephrine
Phenoxybenzamine
Phentolamine
Prazosin
Rats
Vas Deferens
Yohimbine

Source PubMed

Show 9 more topicsShow fewer topics

References11

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	1,149,332	Cardiovascular effects of prazosin in normotensive and genetically hypertensive rats.	Clin Exp Pharmacol Physiol	1975	https://conductscience.org/library/papers/1149332	PubMed
2	13,996,119	Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.	Arch Int Pharmacodyn Ther	1963	https://conductscience.org/library/papers/13996119	PubMed
3	186,273	Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine.	Eur J Pharmacol	1975	https://conductscience.org/library/papers/186273	PubMed
4	235,100	Pre- and postsynaptic components in effect of drugs with alpha adrenoceptor affinity.	Nature	1975	https://conductscience.org/library/papers/235100	PubMed
5	4,155,791	Comparison of the effects of clonidine on pre- and postsynaptic adrenoceptors in the rabbit pulmonary artery. Alpha-sympathomimetic inhibition of Neurogenic vasoconstriction.	Naunyn Schmiedebergs Arch Pharmacol	1974	https://conductscience.org/library/papers/4155791	PubMed
6	4,363,457	Negative feed-back regulation of noradrenaline release by nerve stimulation in the perfused cat's spleen: differences in potency of phenoxybenzamine in blocking the pre- and post-synaptic adrenergic receptors.	J Physiol	1974	https://conductscience.org/library/papers/4363457	PubMed
7	4,397,760	Evidence against adrenergic motor transmission in the guinea-pig vas deferens.	J Physiol	1971	https://conductscience.org/library/papers/4397760	PubMed
8	4,403,611	Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart.	Naunyn Schmiedebergs Arch Pharmacol	1972	https://conductscience.org/library/papers/4403611	PubMed
9	4,617,579	Presynaptic regulation of catecholamine release.	Biochem Pharmacol	1974	https://conductscience.org/library/papers/4617579	PubMed
10	5,158,217	The rat anococcygeus; a new, densely innervated smooth muscle preparation.	Br J Pharmacol	1971	https://conductscience.org/library/papers/5158217	PubMed
11	5,856,313	Dual site of action of phenoxybenzamine in the cat's spleen; blockade of alpha-adrenergic receptors and inhibition of re-uptake of neurally released norepinephrine.	Experientia	1964	https://conductscience.org/library/papers/5856313	PubMed

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Cited by110

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 514 citations.

PMID	Title	Journal	Year	In Papers	Source
36,669,877	Neurochemical and Cardiovascular Effects of 4-Chloro Ring-Substituted Synthetic Cathinones in Rats.	J Pharmacol Exp Ther	2023	https://conductscience.org/library/papers/36669877	PubMed
28,098,360	Morroniside, a secoiridoid glycoside from Cornus officinalis, attenuates neuropathic pain by activation of spinal glucagon-like peptide-1 receptors.	Br J Pharmacol	2017	https://conductscience.org/library/papers/28098360	PubMed
24,311,832	Effect of fractionated extracts and isolated pure compounds of Spondias mombin (L. Anacardiaceae) leaves on novelty-induced rearing and grooming behaviours in mice.	Afr J Tradit Complement Altern Med	2013	https://conductscience.org/library/papers/24311832	PubMed
21,983,967	The effect of intrathecal mu, delta, kappa, and alpha-2 agonists on thermal hyperalgesia induced by mild burn on hind paw in rats.	J Anesth	2011	https://conductscience.org/library/papers/21983967	PubMed
11,986,395	Post-junctional alpha-adrenoceptors and basal limb vascular tone in healthy men.	J Physiol	2002	https://conductscience.org/library/papers/11986395	PubMed
11,691,889	Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented alpha-adrenergic vasoconstriction.	J Physiol	2001	https://conductscience.org/library/papers/11691889	PubMed
8,298,818	Study of the mechanism of the relaxant action of (+)-glaucine in rat vas deferens.	Br J Pharmacol	1993	https://conductscience.org/library/papers/8298818	PubMed
8,106,105	Effect of adrenoceptor agonists on striated muscle strips of the canine oesophagus.	Br J Pharmacol	1993	https://conductscience.org/library/papers/8106105	PubMed
7,773,541	Effect of the vascular endothelium on noradrenaline-induced contractions in non-pregnant and pregnant guinea-pig uterine arteries.	Br J Pharmacol	1995	https://conductscience.org/library/papers/7773541	PubMed
7,470,755	The distribution of adrenoceptors and other drug receptors between the two ends of the rat vas deferens as revealed by selective agonists and antagonists.	Br J Pharmacol	1980	https://conductscience.org/library/papers/7470755	PubMed
7,400,317	Supersensitivity of atherosclerotic rabbit aorta to ergonovine. Mediation by a serotonergic mechanism.	J Clin Invest	1980	https://conductscience.org/library/papers/7400317	PubMed
7,047,170	Prazosin depression of baroreflex function in hypertensive man.	Eur J Clin Pharmacol	1982	https://conductscience.org/library/papers/7047170	PubMed
6,815,543	Hemodynamic alterations produced by N,N-Di-n-propyldopamine in anesthetized dogs.	Naunyn Schmiedebergs Arch Pharmacol	1982	https://conductscience.org/library/papers/6815543	PubMed
6,721,833	Binding and uptake of [3H]adrenaline by perfused rat liver.	Biochem J	1984	https://conductscience.org/library/papers/6721833	PubMed
6,323,526	Functional characterization of the alpha adrenergic receptor modulating the hydroosmotic effect of vasopressin on the rabbit cortical collecting tubule.	J Clin Invest	1984	https://conductscience.org/library/papers/6323526	PubMed
6,322,891	The relative contribution of affinity and efficacy to agonist activity: organ selectivity of noradrenaline and oxymetazoline with reference to the classification of drug receptors.	Br J Pharmacol	1984	https://conductscience.org/library/papers/6322891	PubMed
6,296,704	Evidence supporting the existence of presynaptic alpha-adrenoceptors in the regulation of endogenous noradrenaline release upon hepatic sympathetic nerve stimulation in the dog liver in vivo.	Naunyn Schmiedebergs Arch Pharmacol	1982	https://conductscience.org/library/papers/6296704	PubMed
6,291,687	Dopamine acts at the same receptors as noradrenaline in the rat isolated vas deferens.	Br J Pharmacol	1982	https://conductscience.org/library/papers/6291687	PubMed
6,291,085	Up- and down- regulation of central postsynaptic alpha 2 receptors reflected in the growth hormone response to clonidine in reserpine-pretreated rats.	Psychopharmacology (Berl)	1982	https://conductscience.org/library/papers/6291085	PubMed
6,287,301	Benzamide action at alpha 2-adrenoceptors modifies catecholamine-induced contraction and relaxation of circular smooth muscle from guinea-pig stomach.	Naunyn Schmiedebergs Arch Pharmacol	1982	https://conductscience.org/library/papers/6287301	PubMed

Show 14 more cited byShow fewer cited bySee all 110 cited by

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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