Paper · 183095

Mechanism by which psychotropic drugs inhibit adenosine cyclic 3',5'-monophosphate phosphodiesterase of brain.

Levin RM and 1 other. Mol Pharmacol, 1976. Cited by 479 papers, by iCite.

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ConductScience Library. Mechanism by which psychotropic drugs inhibit adenosine cyclic 3',5'-monophosphate phosphodiesterase of brain. Papers, record 183095. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/183095

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Mechanism by which psychotropic drugs inhibit adenosine cyclic 3',5'-monophosphate phosphodiesterase of brain.; PubMed
Journal: Mol Pharmacol; PubMed
Year: 1976; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/183095/; PubMed
The journal: https://conductscience.org/library/journal-index/0035623; PubMed
Citations, by iCite: 479; iCite
Relative citation ratio, by iCite: 16; iCite
Revised in PubMed: 2014-11-20; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Levin RM	R M
2	Weiss B	B

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
3',5'-Cyclic-AMP Phosphodiesterases	Major topic
Brain	Major topic
Phosphodiesterase Inhibitors	Major topic
Psychotropic Drugs	Major topic
2',3'-Cyclic-Nucleotide Phosphodiesterases
Animals
Calcium
Cattle
Chlorpromazine
Cyclic GMP
Egtazic Acid
Enzyme Activation
In Vitro Techniques
Rats
Trifluoperazine

Source PubMed

Grants0

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None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

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None in this release.

Cited by72

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 479 citations.

PMID	Title	Journal	Year	In Papers	Source
41,699,261	Phosphodiesterase signaling in asthma: mechanistic insights and emerging therapeutic strategies.	Naunyn Schmiedebergs Arch Pharmacol	2026	https://conductscience.org/library/papers/41699261	PubMed
28,496,122	Structural insights into a 20.8-kDa tegumental-allergen-like (TAL) protein from Clonorchis sinensis.	Sci Rep	2017	https://conductscience.org/library/papers/28496122	PubMed
27,809,794	Alternative pre-approved and novel therapies for the treatment of anthrax.	BMC Infect Dis	2016	https://conductscience.org/library/papers/27809794	PubMed
25,946,093	Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor.	PLoS One	2015	https://conductscience.org/library/papers/25946093	PubMed
24,253,948	Identification of calmodulin in the green alga Mougeotia and its possible function in chloroplast reorientational movement.	Planta	1984	https://conductscience.org/library/papers/24253948	PubMed
24,253,945	Cllmodulin in tip-growing plant cells, visualized by fluorescing calmodulin-binding phenothiazines.	Planta	1984	https://conductscience.org/library/papers/24253945	PubMed
22,561,309	A chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates.	Mol Cell Neurosci	2012	https://conductscience.org/library/papers/22561309	PubMed
21,811,569	Differential gene expression by RamA in ciprofloxacin-resistant Salmonella Typhimurium.	PLoS One	2011	https://conductscience.org/library/papers/21811569	PubMed
16,663,620	Involvement of Calcium and Calmodulin in Membrane Deterioration during Senescence of Pea Foliage.	Plant Physiol	1984	https://conductscience.org/library/papers/16663620	PubMed
16,662,963	Inhibition of cytokinin-regulated responses by calmodulin-binding compounds.	Plant Physiol	1983	https://conductscience.org/library/papers/16662963	PubMed

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Genes0

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None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

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None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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