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Paper · 183132

Cyclic AMP and cyclic GMP may play opposing roles in influencing force of contraction in mammalian myocardium.

Nawrath H. Nature, 1976. Cited by 101 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Cyclic AMP and cyclic GMP may play opposing roles in influencing force of contraction in mammalian myocardium. Papers, record 183132. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/183132

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Cyclic AMP and cyclic GMP may play opposing roles in influencing force of contraction in mammalian myocardium.
PubMed
Journal
Nature
PubMed
Year
1976
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
101
iCite
Relative citation ratio, by iCite
3.58
iCite
Revised in PubMed
2026-10-10
PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Nawrath HH

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cyclic AMPMajor topic
Cyclic GMPMajor topic
Myocardial ContractionMajor topic
Animals
Cats
Heart Atria
Heart Rate
In Vitro Techniques
Papillary Muscles
Rats

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References14

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
15,886,938Kinetics of cyclic adenosine monophosphate changes in rat heart following epinephrine administration.Nature1965https://conductscience.org/library/papers/5886938PubMed
25,271,171Elevation of guanosine 3',5'-cyclic phosphate in rat heart after perfusion with acetylcholine.Proc Natl Acad Sci U S A1970https://conductscience.org/library/papers/5271171PubMed
34,316,610Cardiostimulatory effects of cyclic 3',5'-adenosine monophosphate and its acylated derivatives.Naunyn Schmiedebergs Arch Pharmakol1970https://conductscience.org/library/papers/4316610PubMed
44,346,045Adenosine 3',5'-monophosphate: electrophysiological evidence for a role in synaptic transmission.Science1972https://conductscience.org/library/papers/4346045PubMed
54,340,630[The positive ionotropic effect of dibutyryl-3',5'-AMP on isolated rat atria].Pflugers Arch1972https://conductscience.org/library/papers/4340630PubMed
64,372,339Release of norepinephrine and dopamine-beta-hydroxylase by nerve stimulation. II. Effects of papaverine.J Pharmacol Exp Ther1974https://conductscience.org/library/papers/4372339PubMed
7173,857Papaverine blockade of an inward slow Ca2+ current in guinea pig heart.J Mol Cell Cardiol1975https://conductscience.org/library/papers/173857PubMed
8943,764On the mechanism of the negative inotropic effect of acetylcholine.Pflugers Arch1976https://conductscience.org/library/papers/943764PubMed
9163,488Cyclic AMP and cyclic GMP may mediate opposite neuronal responses in the rat cerebral cortex.Science1975https://conductscience.org/library/papers/163488PubMed
104,352,122Influence of cyclization and acyl substitution on the inotropic effects of adenine nucleotides.Naunyn Schmiedebergs Arch Pharmacol1973https://conductscience.org/library/papers/4352122PubMed

1 to 10 of 14

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Cited by24

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 101 citations.

PMIDTitleJournalYearIn PapersSource
11,389,195Cyclic GMP regulation of the L-type Ca(2+) channel current in human atrial myocytes.J Physiol2001https://conductscience.org/library/papers/11389195PubMed
8,680,744The ineffectiveness of the NO-cyclic GMP signaling pathway in the atrial myocardium.Br J Pharmacol1995https://conductscience.org/library/papers/8680744PubMed
8,584,049Extracellular site of action of phenylalkylamines on L-type calcium current in rat ventricular myocytes.Naunyn Schmiedebergs Arch Pharmacol1995https://conductscience.org/library/papers/8584049PubMed
6,653,721Adenosine activates a potassium conductance in guinea-pig atrial heart muscle.Experientia1983https://conductscience.org/library/papers/6653721PubMed
6,283,554Cyclic GMP mimics the muscarinic response in Xenopus oocytes: identity of ionic mechanisms.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6283554PubMed
6,273,536Are acetylcholine-induced increases in 42K efflux mediated by intracellular cyclic GMP in turtle cardiac pace-maker tissue?J Physiol1981https://conductscience.org/library/papers/6273536PubMed
6,263,387Differential responses to carbachol, sodium nitroprusside and 8-bromo-guanosine 3',5'-monophosphate of canine atrial and ventricular muscle.Br J Pharmacol1981https://conductscience.org/library/papers/6263387PubMed
6,252,042The mechanical and biochemical effects of pentoxifylline on the perfused rat heart.Experientia1980https://conductscience.org/library/papers/6252042PubMed
6,250,085The time course of changes in cyclic nucleotide levels during cholinergic inhibition of positive inotropic actions of isoprenaline and theophylline in the isolated canine ventricular myocardium.Naunyn Schmiedebergs Arch Pharmacol1980https://conductscience.org/library/papers/6250085PubMed
6,168,488A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors.Experientia1981https://conductscience.org/library/papers/6168488PubMed

1 to 10 of 24

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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