Paper · 193045

Does cyclic GMP mediate the negative inotropic effect of acetylcholine in the heart?

Nawrath H. Nature, 1977. Cited by 116 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Does cyclic GMP mediate the negative inotropic effect of acetylcholine in the heart? Papers, record 193045. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/193045

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Does cyclic GMP mediate the negative inotropic effect of acetylcholine in the heart?; PubMed
Journal: Nature; PubMed
Year: 1977; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/193045/; PubMed
DOI: https://doi.org/10.1038/267072a0; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 116; iCite
Relative citation ratio, by iCite: 3.35; iCite
Revised in PubMed: 2019-06-17; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Nawrath H	H

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Action Potentials	Major topic
Calcium	Major topic
Cyclic GMP	Major topic
Myocardial Contraction	Major topic
Acetylcholine
Biological Transport
Heart
Myocardium
Potassium
Sodium

Source PubMed

Grants0

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None in this release.

Trials0

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Comments and corrections0

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None in this release.

References0

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Cited by32

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 116 citations.

PMID	Title	Journal	Year	In Papers	Source
8,764,969	Negative inotropic actions of nitric oxide require high doses in rat cardiac muscle.	Pflugers Arch	1996	https://conductscience.org/library/papers/8764969	PubMed
8,680,744	The ineffectiveness of the NO-cyclic GMP signaling pathway in the atrial myocardium.	Br J Pharmacol	1995	https://conductscience.org/library/papers/8680744	PubMed
8,584,047	Evidence against a role of nitric oxide in the indirect negative inotropic-effect of M-cholinoceptor stimulation in human ventricular myocardium.	Naunyn Schmiedebergs Arch Pharmacol	1995	https://conductscience.org/library/papers/8584047	PubMed
7,898,483	Regulation of slow calcium channels of myocardial cells and vascular smooth muscle cells by cyclic nucleotides and phosphorylation.	Mol Cell Biochem	1994	https://conductscience.org/library/papers/7898483	PubMed
7,860,763	Nitric oxide regulates the calcium current in isolated human atrial myocytes.	J Clin Invest	1995	https://conductscience.org/library/papers/7860763	PubMed
7,517,032	Guanylate-cyclase-mediated inhibition of cardiac ICa by carbachol and sodium nitroprusside.	Pflugers Arch	1994	https://conductscience.org/library/papers/7517032	PubMed
7,092,826	Preparation and characterization of muscarinic-acetylcholine-receptor-enriched membranes from pig atria.	Biochem J	1982	https://conductscience.org/library/papers/7092826	PubMed
7,061,988	On the ionic mechanism underlying adrenergic-cholinergic antagonism in ventricular muscle.	J Gen Physiol	1982	https://conductscience.org/library/papers/7061988	PubMed
6,968,315	Distribution of muscarinic acetylcholine receptors and presynaptic nerve terminals in amphibian heart.	J Cell Biol	1980	https://conductscience.org/library/papers/6968315	PubMed
6,653,721	Adenosine activates a potassium conductance in guinea-pig atrial heart muscle.	Experientia	1983	https://conductscience.org/library/papers/6653721	PubMed

1 to 10 of 32

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Genes0

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None in this release.

Drugs0

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None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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