Paper · 198809

Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts.

Shiu RP and 2 others. Proc Natl Acad Sci U S A, 1977. Cited by 356 papers, by iCite.

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ConductScience Library. Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts. Papers, record 198809. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/198809

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1977; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/198809/; PubMed
DOI: https://doi.org/10.1073/pnas.74.9.3840; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC431753/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 356; iCite
Relative citation ratio, by iCite: 6.13; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Shiu RP	R P
2	Pouyssegur J	J
3	Pastan I	I

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Avian Sarcoma Viruses	Major topic
Cell Transformation, Viral	Major topic
Glucose	Major topic
Membrane Proteins	Major topic
Animals
Chick Embryo
Culture Media
Fibroblasts
Kinetics
Molecular Weight

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References14

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
2	189,303	Isolation from normal and Rous sarcoma virus-transformed chicken fibroblasts of a factor that binds glucose and stimulates its transport.	Proc Natl Acad Sci U S A	1977	https://conductscience.org/library/papers/189303	PubMed
3	851,220	Direct detection of antigens in sodium dodecyl sulfate-polyacrylamide gels.	Anal Biochem	1977	https://conductscience.org/library/papers/851220	PubMed
4	1,068,469	Correlation between tumor induction and the large external transformation sensitive protein on the cell surface.	Proc Natl Acad Sci U S A	1976	https://conductscience.org/library/papers/1068469	PubMed
5	4,301,859	Studies on the fixation and development of cellular transformation by Rous sarcoma virus.	Virology	1968	https://conductscience.org/library/papers/4301859	PubMed
6	165,707	Comparisons of major cell-surface proteins of normal and transformed cells.	Am J Clin Pathol	1975	https://conductscience.org/library/papers/165707	PubMed
7	4,508,330	Enhancement of hexose entry into chick fibroblasts by starvation: differential effect on galactose and glucose.	Proc Natl Acad Sci U S A	1972	https://conductscience.org/library/papers/4508330	PubMed
8	4,371,599	Transport of sugars in tumor cell membranes.	Biochim Biophys Acta	1974	https://conductscience.org/library/papers/4371599	PubMed
9	4,362,554	Changes in membrane polypeptides that occur when chick embryo fibroblasts and NRK cells are transformed with avian sarcoma viruses.	Virology	1974	https://conductscience.org/library/papers/4362554	PubMed
10	4,342,244	Temperature-dependent transformation of cells infected with a mutant of Bryan Rous sarcoma virus.	J Virol	1972	https://conductscience.org/library/papers/4342244	PubMed
11	167,516	Alterations in membrane polypeptides of chick embryo fibroblasts induced by transformation with avian sarcoma viruses.	Virology	1975	https://conductscience.org/library/papers/167516	PubMed

1 to 10 of 14

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Cited by126

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 356 citations.

PMID	Title	Journal	Year	In Papers	Source
42,544,575	JNK and p53 cause human and mouse β cell death during excessive unfolded protein response.	J Clin Invest	2026	https://conductscience.org/library/papers/42544575	PubMed
42,370,180	GRP78 in human diseases: From molecular chaperone to therapeutic target.	Theranostics	2026	https://conductscience.org/library/papers/42370180	PubMed
42,247,112	Cell surface GRP78 and the UPR pathway as novel promising therapeutic targets in cancer: an insight into the treatment of acute leukemia by using GRP78-CART cells.	Clin Transl Oncol	2026	https://conductscience.org/library/papers/42247112	PubMed
41,986,307	Endoplasmic reticulum stress in disease pathogenesis: its implications for therapy.	Signal Transduct Target Ther	2026	https://conductscience.org/library/papers/41986307	PubMed
40,699,920	Stress-induced translocation of the endoplasmic reticulum chaperone GRP78/BiP and its impact on human disease and therapy.	Proc Natl Acad Sci U S A	2025	https://conductscience.org/library/papers/40699920	PubMed
40,595,094	Endoplasmic reticulum stress involved in age-related nuclear cataract induced by sodium selenite.	Sci Rep	2025	https://conductscience.org/library/papers/40595094	PubMed
40,002,794	GRP78 in Glioma Progression and Therapy: Implications for Targeted Approaches.	Biomedicines	2025	https://conductscience.org/library/papers/40002794	PubMed
39,090,453	Regulation of lipid metabolism in grass carp primary hepatocytes by exosomes derived from fatty hepatocytes though GRP78.	Fish Physiol Biochem	2024	https://conductscience.org/library/papers/39090453	PubMed
39,086,958	The IRE1α pathway in glomerular diseases: The unfolded protein response and beyond.	Front Mol Med	2022	https://conductscience.org/library/papers/39086958	PubMed
37,605,113	Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review.	Mol Med	2023	https://conductscience.org/library/papers/37605113	PubMed

1 to 10 of 126

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Genes0

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None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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