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Paper1997476

5-Hydroxytryptamine (serotonin) subtype 3 antagonists, a major step in prophylaxis and control of cytostatic and radiation-induced emesis.

Bremer K. J Cancer Res Clin Oncol, 1991. Cited by 7 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. 5-Hydroxytryptamine (serotonin) subtype 3 antagonists, a major step in prophylaxis and control of cytostatic and radiation-induced emesis. Papers, record 1997476. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/1997476

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
5-Hydroxytryptamine (serotonin) subtype 3 antagonists, a major step in prophylaxis and control of cytostatic and radiation-induced emesis.
PubMed
Journal
J Cancer Res Clin Oncol
PubMed
Year
1991
PubMed
Publication types
Journal Article, Review
PubMed
Citations, by iCite
7
iCite
Relative citation ratio, by iCite
0.47
iCite
Revised in PubMed
2025-07-19
PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Bremer KK

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antineoplastic AgentsMajor topic
NauseaMajor topic
RadiotherapyMajor topic
Serotonin AntagonistsMajor topic
VomitingMajor topic
Antiemetics
Antineoplastic Combined Chemotherapy Protocols
Humans

Source PubMed

References22

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1239,122Cardiovascular dopamine receptor stimulation antagonized by metoclopramide.J Pharm Pharmacol1975https://conductscience.org/library/papers/239122PubMed
22,169,786The role of specific 5-HT3 receptor antagonism in the control of cytostatic drug-induced emesis.Eur J Cancer1990https://conductscience.org/library/papers/2169786PubMed
32,169,782The efficacy of granisetron as a prophylactic anti-emetic and intervention agent in high-dose cisplatin-induced emesis.Eur J Cancer1990https://conductscience.org/library/papers/2169782PubMed
42,137,902Comparison of the 5-hydroxytryptamine3 (serotonin) antagonist ondansetron (GR 38032F) with high-dose metoclopramide in the control of cisplatin-induced emesis.N Engl J Med1990https://conductscience.org/library/papers/2137902PubMed
52,169,781The symptomatic control of cytostatic drug-induced emesis. A recent history and review.Eur J Cancer1990https://conductscience.org/library/papers/2169781PubMed
62,194,642A randomized, double-blind comparison of the antiemetic effect of metoclopramide and lorazepam with or without dexamethasone in patients receiving high-dose cisplatin.Cancer1990https://conductscience.org/library/papers/2194642PubMed
7658,121Blockade of neuronal tryptamine receptors by metoclopramide.Eur J Pharmacol1978https://conductscience.org/library/papers/658121PubMed
82,169,785An overview on the use of granisetron in the treatment of emesis associated with cytostatic chemotherapy.Eur J Cancer1990https://conductscience.org/library/papers/2169785PubMed
96,681,766On the receiving end--patient perception of the side-effects of cancer chemotherapy.Eur J Cancer Clin Oncol1983https://conductscience.org/library/papers/6681766PubMed
102,566,845Ondansetron with and without dexamethasone to treat chemotherapy-induced emesis.Lancet1989https://conductscience.org/library/papers/2566845PubMed
111,689,807Efficacy of ondansetron (GR 38032F) and the role of serotonin in cisplatin-induced nausea and vomiting.N Engl J Med1990https://conductscience.org/library/papers/1689807PubMed
123,929,968Extrapyramidal reactions with metoclopramide.Br Med J (Clin Res Ed)1985https://conductscience.org/library/papers/3929968PubMed
132,169,784Efficacy and safety of granisetron compared with high-dose metoclopramide plus dexamethasone in patients receiving high-dose cisplatin in a single-blind study. The Granisetron Study Group.Eur J Cancer1990https://conductscience.org/library/papers/2169784PubMed
147,024,807Antiemetic efficacy of high-dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting.N Engl J Med1981https://conductscience.org/library/papers/7024807PubMed
152,169,783
A comparative study of the use of granisetron, a selective 5-HT3 antagonist, versus a standard anti-emetic regimen of chlorpromazine plus dexamethasone in the treatment of cytostatic-induced emesis. The Granisetron Study Group.
Eur J Cancer1990https://conductscience.org/library/papers/2169783PubMed
162,138,031Ondansetron (GR38032F) plus dexamethasone: effective anti-emetic prophylaxis for patients receiving cytotoxic chemotherapy.Br J Cancer1990https://conductscience.org/library/papers/2138031PubMed
175,495,441Effects of metoclopramide on isolated guinea-pig colon. 2. Interference with ganglionic stimulant drugs.Eur J Pharmacol1970https://conductscience.org/library/papers/5495441PubMed
184,045,527Incidence, course, and severity of delayed nausea and vomiting following the administration of high-dose cisplatin.J Clin Oncol1985https://conductscience.org/library/papers/4045527PubMed
192,533,893Proceedings of the Ondansetron Symposium. London, 30 June 1989.Eur J Cancer Clin Oncol1989https://conductscience.org/library/papers/2533893PubMed
203,790,968Optimising antiemesis in cancer chemotherapy: efficacy of continuous versus intermittent infusion of high dose metoclopramide in emesis induced by cisplatin.Br Med J (Clin Res Ed)1986https://conductscience.org/library/papers/3790968PubMed

See all 22 references

Cited by2

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 7 citations.

PMIDTitleJournalYearIn PapersSource
28,364,173A systematic review of methodologies, endpoints, and outcome measures in randomized trials of radiation therapy-induced nausea and vomiting.Support Care Cancer2017https://conductscience.org/library/papers/28364173PubMed
10,325,923Role of serotonin in the pathogenesis of acute and chronic pulmonary hypertension.Thorax1999https://conductscience.org/library/papers/10325923PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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