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Paper20007533

Peptide-MHC class II complex stability governs CD4 T cell clonal selection.

Baumgartner CK and 4 others. J Immunol, 2010. Cited by 35 papers, by iCite.

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ConductScience Library. Peptide-MHC class II complex stability governs CD4 T cell clonal selection. Papers, record 20007533. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/20007533

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Peptide-MHC class II complex stability governs CD4 T cell clonal selection.
PubMed
Journal
J Immunol
PubMed
Year
2010
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
35
iCite
Relative citation ratio, by iCite
0.72
iCite
Revised in PubMed
2025-05-29
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Baumgartner CKChristina K
2Ferrante AAndrea
3Nagaoka MMika
4Gorski JJack
5Malherbe LPLaurent P

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
CD4-Positive T-LymphocytesMajor topic
Histocompatibility Antigens Class IIMajor topic
PeptidesMajor topic
Animals
Autoimmunity
Clone Cells
Half-Life
Immunization
Mice
Mutation
Protein Stability

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
J 2851Austrian Science Fund FWFAustriaPubMed
U19 A162627PHS HHSUnited StatesPubMed

Source PubMed

References38

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
110,449,771An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro.Proc Natl Acad Sci U S A1999https://conductscience.org/library/papers/10449771PubMed
210,229,191A kinetic basis for T cell receptor repertoire selection during an immune response.Immunity1999https://conductscience.org/library/papers/10229191PubMed
312,459,592Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense.Science2002https://conductscience.org/library/papers/12459592PubMed
411,956,295Structural basis of cytochrome c presentation by IE(k).J Exp Med2002https://conductscience.org/library/papers/11956295PubMed
511,904,393Dissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation.Proc Natl Acad Sci U S A2002https://conductscience.org/library/papers/11904393PubMed
611,801,666C-terminal anchoring of a peptide to class II MHC via the P10 residue is compatible with a peptide bulge.J Immunol2002https://conductscience.org/library/papers/11801666PubMed
716,039,577The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance.Immunity2005https://conductscience.org/library/papers/16039577PubMed
811,207,290Structural and functional consequences of altering a peptide MHC anchor residue.J Immunol2001https://conductscience.org/library/papers/11207290PubMed
99,143,690Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches.Annu Rev Immunol1997https://conductscience.org/library/papers/9143690PubMed
1017,881,563Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation.Proc Natl Acad Sci U S A2007https://conductscience.org/library/papers/17881563PubMed
113,012,351Correlations between T-cell specificity and the structure of the antigen receptor.Nature1986https://conductscience.org/library/papers/3012351PubMed
1215,100,274The magnitude of TCR engagement is a critical predictor of T cell anergy or activation.J Immunol2004https://conductscience.org/library/papers/15100274PubMed
1314,690,592Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation.Mol Cell2003https://conductscience.org/library/papers/14690592PubMed
1411,163,193Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major.Immunity2000https://conductscience.org/library/papers/11163193PubMed
159,655,481Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes.Immunity1998https://conductscience.org/library/papers/9655481PubMed
168,145,819Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide.Nature1994https://conductscience.org/library/papers/8145819PubMed
1717,627,303A public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE.J Clin Invest2007https://conductscience.org/library/papers/17627303PubMed
1811,120,826Distinct T cell interactions with HLA class II tetramers characterize a spectrum of TCR affinities in the human antigen-specific T cell response.J Immunol2000https://conductscience.org/library/papers/11120826PubMed
197,535,476Antigen-specific development of primary and memory T cells in vivo.Science1995https://conductscience.org/library/papers/7535476PubMed
2018,251,991Class II major histocompatibility complex tetramer staining: progress, problems, and prospects.Immunology2008https://conductscience.org/library/papers/18251991PubMed

See all 38 references

Cited by30

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 35 citations.

PMIDTitleJournalYearIn PapersSource
42,657,027Phosphorylation shapes antigen presentation and immune recognition: mechanistic insights and translational perspectives.Front Immunol2026https://conductscience.org/library/papers/42657027PubMed
42,589,216Structural Remodeling of TCR-HLA-DQ8 Recognition by a β-Cell Stress-Associated C19S Insulin Neoepitope in Type 1 Diabetes.Int J Mol Sci2026https://conductscience.org/library/papers/42589216PubMed
42,278,376Structural Modulation and Binding of HLA-DQ8 by Cysteine-to-Serine Mutated Insulin Peptide: Insights from Molecular Dynamics Simulations.Int J Mol Sci2026https://conductscience.org/library/papers/42278376PubMed
39,475,096PRR adjuvants restrain high stability peptides presentation on APCs.Elife2024https://conductscience.org/library/papers/39475096PubMed
39,136,115How do adjuvants enhance immune responses?Elife2024https://conductscience.org/library/papers/39136115PubMed
38,250,071H2-O deficiency promotes regulatory T cell differentiation and CD4 T cell hyperactivity.Front Immunol2023https://conductscience.org/library/papers/38250071PubMed
38,102,157An immunoinformatics study reveals a new BoLA-DR-restricted CD4+ T cell epitopes on the Gag protein of bovine leukemia virus.Sci Rep2023https://conductscience.org/library/papers/38102157PubMed
34,997,058High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD).Sci Rep2022https://conductscience.org/library/papers/34997058PubMed
34,433,672PD-1 preferentially inhibits the activation of low-affinity T cells.Proc Natl Acad Sci U S A2021https://conductscience.org/library/papers/34433672PubMed
34,266,882Influence of DM-sensitivity on immunogenicity of MHC class II restricted antigens.J Immunother Cancer2021https://conductscience.org/library/papers/34266882PubMed
34,026,437Gas Plasma Technology Augments Ovalbumin Immunogenicity and OT-II T Cell Activation Conferring Tumor Protection in Mice.Adv Sci (Weinh)2021https://conductscience.org/library/papers/34026437PubMed
30,778,242Quantifying in situ adaptive immune cell cognate interactions in humans.Nat Immunol2019https://conductscience.org/library/papers/30778242PubMed
30,379,846Amino acid signatures in the HLA class II peptide-binding region associated with protection/susceptibility to the severe West Nile Virus disease.PLoS One2018https://conductscience.org/library/papers/30379846PubMed
30,349,037LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII.Nat Immunol2018https://conductscience.org/library/papers/30349037PubMed
26,906,089Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes.J Immunol Methods2016https://conductscience.org/library/papers/26906089PubMed
26,870,289Myeloid-derived suppressor cells enhance the expression of melanoma-associated antigen A4 in a Lewis lung cancer murine model.Oncol Lett2016https://conductscience.org/library/papers/26870289PubMed
26,779,136Strategic Priming with Multiple Antigens can Yield Memory Cell Phenotypes Optimized for Infection with Mycobacterium tuberculosis: A Computational Study.Front Microbiol2015https://conductscience.org/library/papers/26779136PubMed
25,485,681Cell-surface MHC density profiling reveals instability of autoimmunity-associated HLA.J Clin Invest2015https://conductscience.org/library/papers/25485681PubMed
25,086,170Antigen signal strength during priming determines effector CD4 T cell function and antigen sensitivity during influenza virus challenge.J Immunol2014https://conductscience.org/library/papers/25086170PubMed
24,167,504The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilings.Front Immunol2013https://conductscience.org/library/papers/24167504PubMed

See all 30 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

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  • ClinicalTrials.govNo license stated
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  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
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  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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