Paper · 20081841

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis.

Joe AW and 7 others. Nat Cell Biol, 2010. Cited by 1,373 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Papers, record 20081841. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/20081841

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis.; PubMed
Journal: Nat Cell Biol; PubMed
Year: 2010; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/20081841/; PubMed
DOI: https://doi.org/10.1038/ncb2015; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC4580288/; PubMed
The journal: https://conductscience.org/library/journal-index/100890575; PubMed
Citations, by iCite: 1,373; iCite
Relative citation ratio, by iCite: 33.9; iCite
Revised in PubMed: 2022-04-10; PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Joe AW	Aaron W B
2	Yi L	Lin
3	Natarajan A	Anuradha
4	Le Grand F	Fabien
5	So L	Leslie
6	Wang J	Joy
7	Rudnicki MA	Michael A
8	Rossi FM	Fabio M V

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Adipocytes	Major topic
Muscle Development	Major topic
Muscle Fibers, Skeletal	Major topic
Muscle, Skeletal	Major topic
Stem Cells	Major topic
Animals
Cell Differentiation
Cell Proliferation
Cells, Cultured
Flow Cytometry
Mice
Mice, Inbred C57BL
Mice, Transgenic
Myoblasts
Stem Cell Transplantation

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
R01 AR044031	NIAMS NIH HHS	United States	R01AR044031	PubMed and NIH	NIH RePORTER
MOP-97856	CIHR	Canada		PubMed	PubMed
CSB-94219	CIHR	Canada		PubMed	PubMed
MUS-94019	CIHR	Canada		PubMed	PubMed

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

Trial	Title	The trial lists it as	Named in the paper's record
NCT04998500	Growth Hormone as a Model for Reversible Activation of Adipose Tissue Fibrosis	Background

Source ClinicalTrials.gov

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

Kind	PMID	Title	In Papers
Comment in	20,081,844	Tipping the scale: muscle versus fat.	https://conductscience.org/library/papers/20081844

Source PubMed

References44

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	16,720,640	Human macrophages rescue myoblasts and myotubes from apoptosis through a set of adhesion molecular systems.	J Cell Sci	2006	https://conductscience.org/library/papers/16720640	PubMed
2	19,217,431	Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis.	Dev Cell	2009	https://conductscience.org/library/papers/19217431	PubMed
3	12,837,243	Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration.	Cell	2003	https://conductscience.org/library/papers/12837243	PubMed
4	16,141,372	Direct isolation of satellite cells for skeletal muscle regeneration.	Science	2005	https://conductscience.org/library/papers/16141372	PubMed
5	16,109,764	Optimizing techniques for tracking transplanted stem cells in vivo.	Stem Cells	2005	https://conductscience.org/library/papers/16109764	PubMed
6	11,302,686	Purification of mouse primary myoblasts based on alpha 7 integrin expression.	Exp Cell Res	2001	https://conductscience.org/library/papers/11302686	PubMed
7	12,361,602	The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis.	Dev Cell	2002	https://conductscience.org/library/papers/12361602	PubMed
8	14,982,854	Transforming growth factor-beta1 induces the differentiation of myogenic cells into fibrotic cells in injured skeletal muscle: a key event in muscle fibrogenesis.	Am J Pathol	2004	https://conductscience.org/library/papers/14982854	PubMed
9	18,806,774	Self-renewal and expansion of single transplanted muscle stem cells.	Nature	2008	https://conductscience.org/library/papers/18806774	PubMed
10	11,121,437	Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cells.	J Cell Biol	2000	https://conductscience.org/library/papers/11121437	PubMed

1 to 10 of 44

See all 44 references

Cited by1,046

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,373 citations.

PMID	Title	Journal	Year	In Papers	Source
42,966,891	RUNX1-Mediated Hypoxic Signaling Impairs Myogenesis and Promotes Fibrosis in Myopathies.	Adv Sci (Weinh)	2026	https://conductscience.org/library/papers/42966891	PubMed
42,951,861	Senescent Mesenchymal Stromal Cells Drive Stem Cell Aging Through Dysregulated Chemokine Synthesis.	Aging Cell	2026	https://conductscience.org/library/papers/42951861	PubMed
42,941,799	Compartment-Specific Transcriptional Remodelling Defines Denervation and Geriatric Muscle Regeneration.	Int J Mol Sci	2026	https://conductscience.org/library/papers/42941799	PubMed
42,939,999	Chronic Inflammation, Fibrotic Remodeling, and Regenerative Failure in Duchenne Muscular Dystrophy: Mechanisms and Therapeutic Opportunities.	Biomedicines	2026	https://conductscience.org/library/papers/42939999	PubMed
42,939,618	A Cross-Condition Single-Cell Atlas Defines Skeletal Muscle Adaptation and Its Predictive Limits.	Curr Issues Mol Biol	2026	https://conductscience.org/library/papers/42939618	PubMed
42,885,103	Fibro-Adipogenic Progenitors From Skeletal Muscle Enhance Microvascular Angiogenesis in a 3D Model.	Adv Biol (Weinh)	2026	https://conductscience.org/library/papers/42885103	PubMed
42,882,441	Physiological Reference Mapping Reveals Context-Dependent Dysregulation of Regenerative Programs in Duchenne Muscular Dystrophy.	Cells	2026	https://conductscience.org/library/papers/42882441	PubMed
42,856,131	Pathogenic transcriptional reprogramming of fibro-adipogenic progenitors in mice with FOP and its mitigation by inhibition of ACVR1 and activin A.	bioRxiv	2026	https://conductscience.org/library/papers/42856131	PubMed
42,807,134	Tendon-muscle-nerve disconnection in chronic large and massive posterosuperior rotator cuff tears: a targeted narrative mechanistic review and hypothesis-generating framework.	Front Cell Dev Biol	2026	https://conductscience.org/library/papers/42807134	PubMed
42,793,070	State-Dependent FGF Signaling in Satellite Cell-Mediated Skeletal Muscle Regeneration and Pathological Remodeling.	Biomolecules	2026	https://conductscience.org/library/papers/42793070	PubMed

1 to 10 of 1,046

See all 1,046 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
PRB1	5,542	PubTator's text mining	https://conductscience.org/library/genes/5542

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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