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Paper · 20160101

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors.

Curran MA and 3 others. Proc Natl Acad Sci U S A, 2010. Cited by 1,530 papers, by iCite.

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ConductScience Library. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Papers, record 20160101. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/20160101

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
2010
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
1,530
iCite
Relative citation ratio, by iCite
32
iCite
Revised in PubMed
2022-04-10
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Curran MAMichael A
2Montalvo WWelby
3Yagita HHideo
4Allison JPJames P

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antigens, DifferentiationMajor topic
Bone Marrow CellsMajor topic
GranzymesMajor topic
Melanoma, ExperimentalMajor topic
T-Lymphocytes, RegulatoryMajor topic
Animals
Cancer Vaccines
Interferon-gamma
Programmed Cell Death 1 Receptor

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
Howard Hughes Medical InstituteUnited StatesPubMed

Source PubMed

Trials2

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's recordSource
NCT04019964Nivolumab in Biochemically Recurrent dMMR Prostate CancerBackgroundClinicalTrials.gov
NCT04815720Pepinemab in Combination With Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and NeckBackgroundClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References28

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
112,668,647Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo.J Exp Med2003https://conductscience.org/library/papers/12668647PubMed
27,584,144Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.Immunity1995https://conductscience.org/library/papers/7584144PubMed
319,651,643PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+ CD25(Hi) regulatory T cells.Int Immunol2009https://conductscience.org/library/papers/19651643PubMed
410,430,624
Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation.
J Exp Med1999https://conductscience.org/library/papers/10430624PubMed
519,197,294Myeloid-derived suppressor cells as regulators of the immune system.Nat Rev Immunol2009https://conductscience.org/library/papers/19197294PubMed
610,485,649Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.Immunity1999https://conductscience.org/library/papers/10485649PubMed
717,850,588Agonistic anti-4-1BB antibody promotes the expansion of natural regulatory T cells while maintaining Foxp3 expression.Scand J Immunol2007https://conductscience.org/library/papers/17850588PubMed
815,184,501CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion.J Exp Med2004https://conductscience.org/library/papers/15184501PubMed
919,738,077Tumor vaccines expressing flt3 ligand synergize with ctla-4 blockade to reject preimplanted tumors.Cancer Res2009https://conductscience.org/library/papers/19738077PubMed
1016,034,097Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production.J Immunol2005https://conductscience.org/library/papers/16034097PubMed

1 to 10 of 28

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Cited by1,063

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,530 citations.

PMIDTitleJournalYearIn PapersSource
42,955,091From forward-backward sweep to backpropagation for optimal control in tumor-immune dynamics.J Math Biol2026https://conductscience.org/library/papers/42955091PubMed
42,954,362Neoadjuvant Therapy for Non-Small Cell Lung Cancer: Recent Advances and Future Directions.Cancer Med2026https://conductscience.org/library/papers/42954362PubMed
42,906,944Tarloxotinib targets tumor hypoxia to improve therapeutic efficacy of immune checkpoint inhibition in a MyD88-dependent manner.J Immunother Cancer2026https://conductscience.org/library/papers/42906944PubMed
42,797,394Efficacy and Safety of Cadonilimab in Digestive System Neoplasms: A Systematic Review and Single-Arm Meta-Analysis.Pharmaceuticals (Basel)2026https://conductscience.org/library/papers/42797394PubMed
42,769,030Spatial Treg niches and the therapeutic reprogramming of tumour tolerance in cancer.Front Cell Dev Biol2026https://conductscience.org/library/papers/42769030PubMed
42,764,900Advances of oral micro- and nanomedicines for modulating intestinal barriers in the treatment of intestinal diseases.Acta Pharm Sin B2026https://conductscience.org/library/papers/42764900PubMed
42,346,126Myeloid-Derived Suppressor Cells: Function, Migration, and Therapeutic Opportunities in Glioblastoma.Cells2026https://conductscience.org/library/papers/42346126PubMed
42,338,691Etiology-Based Treatment for Unresectable/Advanced Hepatocellular Carcinoma: Focus on Viral Hepatitis and Metabolic Dysfunction-Associated Steatohepatitis.Liver Cancer2026https://conductscience.org/library/papers/42338691PubMed
42,310,165Compensatory relationships determine the impact of TGF-β on the humoral immune response to hepatitis B surface antigen.J Immunol2026https://conductscience.org/library/papers/42310165PubMed
42,292,456Immune regulatory mechanisms in the tumor microenvironment and their applications in cancer therapy: from basic research to clinical translation.Front Immunol2026https://conductscience.org/library/papers/42292456PubMed

1 to 10 of 1,063

See all 1,063 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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