Paper20962000

Hydrogen ion dynamics in human red blood cells.

Swietach P and 7 others. J Physiol, 2010. Cited by 59 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Hydrogen ion dynamics in human red blood cells. Papers, record 20962000. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/20962000

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Hydrogen ion dynamics in human red blood cells.; PubMed
Journal: J Physiol; PubMed
Year: 2010; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/20962000/; PubMed
DOI: https://doi.org/10.1113/jphysiol.2010.197392; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC3036193/; PubMed
The journal: https://conductscience.org/library/journal-index/0266262; PubMed
Citations, by iCite: 59; iCite
Relative citation ratio, by iCite: 1.73; iCite
Revised in PubMed: 2025-05-29; PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Swietach P	Pawel
2	Tiffert T	Teresa
3	Mauritz JM	Jakob M A
4	Seear R	Rachel
5	Esposito A	Alessandro
6	Kaminski CF	Clemens F
7	Lew VL	Virgilio L
8	Vaughan-Jones RD	Richard D

Source PubMed

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Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Erythrocytes	Major topic
Protons	Major topic
Anion Exchange Protein 1, Erythrocyte
Benzopyrans
Bicarbonates
Buffers
Carbon Dioxide
Chlorides
Fluorescence
Humans
Hydrogen-Ion Concentration
Naphthols
Rhodamines

Source PubMed

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Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	Stated by
G0700698	Medical Research Council	United Kingdom	PubMed
089703	Wellcome Trust	United Kingdom	PubMed
RG/08/016/26423	British Heart Foundation	United Kingdom	PubMed
BB/E008542/1	Biotechnology and Biological Sciences Research Council	United Kingdom	PubMed
MC_G1000734	Medical Research Council	United Kingdom	PubMed

Source PubMed

References61

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	9,794,723	Enhanced Na+/H+ exchange in Cushing's syndrome reflects functional hypermineralocorticoidism.	J Hypertens	1998	https://conductscience.org/library/papers/9794723	PubMed
2	3,970,916	Pyruvate prevents the ATP depletion caused by formaldehyde or calcium-chelator esters in the human red cell.	Biochim Biophys Acta	1985	https://conductscience.org/library/papers/3970916	PubMed
3	4,515,993	Equilibrium dialysis of ions in nystatin-treated red cells.	Nat New Biol	1973	https://conductscience.org/library/papers/4515993	PubMed
4	1,985,088	A mathematical model of the volume, pH, and ion content regulation in reticulocytes. Application to the pathophysiology of sickle cell dehydration.	J Clin Invest	1991	https://conductscience.org/library/papers/1985088	PubMed
5	7,528,276	Regulation of intracellular pH in the smooth muscle of guinea-pig ureter: HCO3- dependence.	J Physiol	1994	https://conductscience.org/library/papers/7528276	PubMed
6	8,621,440	The cytoplasmic and transmembrane domains of AE2 both contribute to regulation of anion exchange by pH.	J Biol Chem	1996	https://conductscience.org/library/papers/8621440	PubMed
7	12,759,755	The SLC26 gene family of multifunctional anion exchangers.	Pflugers Arch	2004	https://conductscience.org/library/papers/12759755	PubMed
8	6,852,250	Band-3 protein-mediated anion conductance of the red cell membrane. Slippage vs ionic diffusion.	FEBS Lett	1983	https://conductscience.org/library/papers/6852250	PubMed
9	13,204	Chloride transport in human erythrocytes and ghosts: a quantitative comparison.	J Physiol	1976	https://conductscience.org/library/papers/13204	PubMed
10	15,498,800	Slc26a6: a cardiac chloride-hydroxyl exchanger and predominant chloride-bicarbonate exchanger of the mouse heart.	J Physiol	2004	https://conductscience.org/library/papers/15498800	PubMed
11	1,702,096	Evidence for a direct reticulocyte origin of dense red cells in sickle cell anemia.	J Clin Invest	1991	https://conductscience.org/library/papers/1702096	PubMed
12	3,151,493	Detection and separation of human red cells with different calcium contents following uniform calcium permeabilization.	J Physiol	1988	https://conductscience.org/library/papers/3151493	PubMed
14	11,179,033	AE anion exchangers in atrial tumor cells.	Am J Physiol Heart Circ Physiol	2001	https://conductscience.org/library/papers/11179033	PubMed
15	2,042,971	The band 3-related anion exchanger (AE) gene family.	Annu Rev Physiol	1991	https://conductscience.org/library/papers/2042971	PubMed
16	5,967,184	Ion and water shifts produced by ammonium chloride in high K and low K red cells.	J Cell Physiol	1966	https://conductscience.org/library/papers/5967184	PubMed
17	7,012,859	Intracellular pH.	Physiol Rev	1981	https://conductscience.org/library/papers/7012859	PubMed
18	7,795,242	Generation of normal human red cell volume, hemoglobin content, and membrane area distributions by "birth" or regulation?	Blood	1995	https://conductscience.org/library/papers/7795242	PubMed
19	8,866,352	Novel chloride-dependent acid loader in the guinea-pig ventricular myocyte: part of a dual acid-loading mechanism.	J Physiol	1996	https://conductscience.org/library/papers/8866352	PubMed
20	3,949,885	pH-regulated anion antiport in nucleated mammalian cells.	J Cell Biol	1986	https://conductscience.org/library/papers/3949885	PubMed
21	3,612,767	K-permeabilized human red cells lose an alkaline, hypertonic fluid containing excess K over diffusible anions.	J Membr Biol	1987	https://conductscience.org/library/papers/3612767	PubMed

Show 14 more referencesShow fewer referencesSee all 61 references

Cited by36

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 59 citations.

PMID	Title	Journal	Year	In Papers	Source
41,591,904	Soluble adenylyl cyclase in nonmammalian sperm is directly controlled by pH, not by HCO3- or Ca2.	Proc Natl Acad Sci U S A	2026	https://conductscience.org/library/papers/41591904	PubMed
40,631,384	Loss of Na+,HCO3 --Cotransporter NBCn1 Inhibits Net Acid Extrusion in the Atria and Causes Hypertension-Associated Cardiac Hypertrophy.	Acta Physiol (Oxf)	2025	https://conductscience.org/library/papers/40631384	PubMed
39,828,634	Modulation of the Oxygenation State and Intracellular pH of Erythrocytes by Inositol-Trispyrophosphate Investigated by 31P NMR Study of 2,3-DPG.	J Cell Mol Med	2025	https://conductscience.org/library/papers/39828634	PubMed
39,677,490	Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as mortality predictors in acute Aluminum phosphide (grain pills) poisoning: clinical insights and risk assessment.	Toxicol Res (Camb)	2024	https://conductscience.org/library/papers/39677490	PubMed
39,674,089	Assessing the kinetics of oxygen-unloading from red cells using FlowScore, a flow-cytometric proxy of the functional quality of blood.	EBioMedicine	2025	https://conductscience.org/library/papers/39674089	PubMed
39,513,920	The Effect of the Acid-Base Imbalance on the Shape and Structure of Red Blood Cells.	Cells	2024	https://conductscience.org/library/papers/39513920	PubMed
39,408,765	Testing Green Tea Extract and Ammonium Salts as Stimulants of Physical Performance in a Forced Swimming Rat Experimental Model.	Int J Mol Sci	2024	https://conductscience.org/library/papers/39408765	PubMed
39,327,453	Unlocking the electrochemical functions of biomolecular condensates.	Nat Chem Biol	2024	https://conductscience.org/library/papers/39327453	PubMed
39,000,500	Chloride Gradient Is Involved in Ammonium Influx in Human Erythrocytes.	Int J Mol Sci	2024	https://conductscience.org/library/papers/39000500	PubMed
38,177,283	Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion.	Nat Immunol	2024	https://conductscience.org/library/papers/38177283	PubMed
37,505,024	Role of Plasma Membrane at Dielectric Relaxations and Intermembrane Interaction in Human Erythrocytes.	Membranes (Basel)	2023	https://conductscience.org/library/papers/37505024	PubMed
36,588,342	The circulatory dynamics of human red blood cell homeostasis: Oxy-deoxy and PIEZO1-triggered changes.	Biophys J	2023	https://conductscience.org/library/papers/36588342	PubMed
34,669,510	Cell physiology and molecular mechanism of anion transport by erythrocyte band 3/AE1.	Am J Physiol Cell Physiol	2021	https://conductscience.org/library/papers/34669510	PubMed
34,416,110	Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions.	ACS Chem Biol	2021	https://conductscience.org/library/papers/34416110	PubMed
33,690,597	PIEZO1 and the mechanism of the long circulatory longevity of human red blood cells.	PLoS Comput Biol	2021	https://conductscience.org/library/papers/33690597	PubMed
33,633,832	Carbon dioxide-dependent signal transduction in mammalian systems.	Interface Focus	2021	https://conductscience.org/library/papers/33633832	PubMed
32,321,831	Single-cell O2 exchange imaging shows that cytoplasmic diffusion is a dominant barrier to efficient gas transport in red blood cells.	Proc Natl Acad Sci U S A	2020	https://conductscience.org/library/papers/32321831	PubMed
32,305,689	Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders.	Biochim Biophys Acta Proteins Proteom	2020	https://conductscience.org/library/papers/32305689	PubMed
31,286,284	Autologous Blood Transfusion Enhances Exercise Performance-Strength of the Evidence and Physiological Mechanisms.	Sports Med Open	2019	https://conductscience.org/library/papers/31286284	PubMed
30,022,052	The solute carrier SLC9C1 is a Na+/H+-exchanger gated by an S4-type voltage-sensor and cyclic-nucleotide binding.	Nat Commun	2018	https://conductscience.org/library/papers/30022052	PubMed

Show 14 more cited byShow fewer cited bySee all 36 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
SLC4A1	6,521	PubTator's text mining	https://conductscience.org/library/genes/6521

Source NCBI Gene

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

Trials
Comments and corrections
Drugs
Data

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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