Paper209869

Capsaicin-induced depletion of substance P from primary sensory neurones.

Jessell TM and 2 others. Brain Res, 1978. Cited by 456 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Capsaicin-induced depletion of substance P from primary sensory neurones. Papers, record 209869. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/209869

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Capsaicin-induced depletion of substance P from primary sensory neurones.; PubMed
Journal: Brain Res; PubMed
Year: 1978; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/209869/; PubMed
DOI: https://doi.org/10.1016/0006-8993(78)90146-4; PubMed
The journal: https://conductscience.org/library/journal-index/0045503; PubMed
Citations, by iCite: 456; iCite
Relative citation ratio, by iCite: 17.7; iCite
Revised in PubMed: 2019-06-13; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Jessell TM	T M
2	Iversen LL	L L
3	Cuello AC	A C

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Capsaicin	Major topic
Fatty Acids, Unsaturated	Major topic
Spinal Cord	Major topic
Substance P	Major topic
Substantia Gelatinosa	Major topic
Acid Phosphatase
Afferent Pathways
Animals
Fluorescent Antibody Technique
Glutamate Decarboxylase
Male
Rats
Receptors, Opioid

Source PubMed

Show 7 more topicsShow fewer topics

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

Trial	Title	The trial lists it as	Named in the paper's record
NCT03899246	Sickle Cell Pain: Intervention With Capsaicin Exposure	Background

Source ClinicalTrials.gov

Cited by96

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 456 citations.

PMID	Title	Journal	Year	In Papers	Source
41,226,390	Morphological Correlates of TRPV1 Agonist-Induced Activation and Defunctionalization of Nociceptor Neurons.	Int J Mol Sci	2025	https://conductscience.org/library/papers/41226390	PubMed
38,099,210	Unveiling the mechanisms of neuropathic pain suppression: perineural resiniferatoxin targets Trpv1 and beyond.	Front Neuroanat	2023	https://conductscience.org/library/papers/38099210	PubMed
37,206,205	Development of a mammalian neurosensory full-thickness skin equivalent and its application to screen sensitizing stimuli.	Bioeng Transl Med	2023	https://conductscience.org/library/papers/37206205	PubMed
36,986,611	Can Essential Oils/Botanical Agents Smart-Nanoformulations Be the Winning Cards against Psoriasis?	Pharmaceutics	2023	https://conductscience.org/library/papers/36986611	PubMed
36,293,248	Chronic Nodular Prurigo: An Update on the Pathogenesis and Treatment.	Int J Mol Sci	2022	https://conductscience.org/library/papers/36293248	PubMed
36,051,054	Targeting TRPV1 activity via high-dose capsaicin in patients with sickle cell disease.	EJHaem	2022	https://conductscience.org/library/papers/36051054	PubMed
35,011,580	Capsaicin and TRPV1 Channels in the Cardiovascular System: The Role of Inflammation.	Cells	2021	https://conductscience.org/library/papers/35011580	PubMed
33,181,192	Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain.	Pharmacol Ther	2021	https://conductscience.org/library/papers/33181192	PubMed
33,165,872	TRPV1-Targeted Drugs in Development for Human Pain Conditions.	Drugs	2021	https://conductscience.org/library/papers/33165872	PubMed
32,634,530	Substance P-expressing Neurons in the Superficial Dorsal Horn of the Mouse Spinal Cord: Insights into Their Functions and their Roles in Synaptic Circuits.	Neuroscience	2020	https://conductscience.org/library/papers/32634530	PubMed
29,616,309	A historical perspective on the role of sensory nerves in neurogenic inflammation.	Semin Immunopathol	2018	https://conductscience.org/library/papers/29616309	PubMed
29,408,808	Pain control through selective chemo-axotomy of centrally projecting TRPV1+ sensory neurons.	J Clin Invest	2018	https://conductscience.org/library/papers/29408808	PubMed
27,574,462	The effect of intra-articular vanilloid receptor agonists on pain behavior measures in a murine model of acute monoarthritis.	J Pain Res	2016	https://conductscience.org/library/papers/27574462	PubMed
27,455,231	Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases.	Molecules	2016	https://conductscience.org/library/papers/27455231	PubMed
21,852,280	Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch.	Br J Anaesth	2011	https://conductscience.org/library/papers/21852280	PubMed
21,040,852	VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.	Neuron	2010	https://conductscience.org/library/papers/21040852	PubMed
20,426,711	Therapy of pruritus.	Expert Opin Pharmacother	2010	https://conductscience.org/library/papers/20426711	PubMed
19,291,395	Spinal cord transection significantly influences nNOS-IR in neuronal circuitry that underlies the tail-flick reflex activity.	Cell Mol Neurobiol	2009	https://conductscience.org/library/papers/19291395	PubMed
17,874,046	Effects of sensory denervation by neonatal capsaicin administration on experimental pancreatitis induced by dibutyltin dichloride.	Med Mol Morphol	2007	https://conductscience.org/library/papers/17874046	PubMed
16,959,176	Evaluation and management of refractory overactive bladder.	Curr Urol Rep	2006	https://conductscience.org/library/papers/16959176	PubMed

Show 14 more cited byShow fewer cited bySee all 96 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
GLUL	2,752	PubTator's text mining	https://conductscience.org/library/genes/2752	NCBI Gene
TAC1	6,863	PubTator's text mining	https://conductscience.org/library/genes/6863	NCBI Gene

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

Grants
Comments and corrections
References
Drugs
Data

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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