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Paper · 21054

The effects of urine pH and plasma protein binding on the renal clearance of disopyramide.

Cunningham JL and 3 others. Clin Pharmacokinet, 1977. Cited by 81 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The effects of urine pH and plasma protein binding on the renal clearance of disopyramide. Papers, record 21054. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/21054

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The effects of urine pH and plasma protein binding on the renal clearance of disopyramide.
PubMed
Journal
Clin Pharmacokinet
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
81
iCite
Relative citation ratio, by iCite
4.92
iCite
Revised in PubMed
2018-11-13
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Cunningham JLJ L
2Shen DDD D
3Shudo II
4Azarnoff DLD L

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
DisopyramideMajor topic
KidneyMajor topic
PyridinesMajor topic
Administration, Oral
Adult
Half-Life
Humans
Hydrogen-Ion Concentration
Injections, Intravenous
Male
Protein Binding
Urine

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References21

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,026,530Correlation of disopyramide pharmacokinetics with efficacy in ventricular tachyarrhythmia.J Int Med Res1976https://conductscience.org/library/papers/1026530PubMed
21,026,535Acute termination of cardiac arrhythmias with intravenous disopyramide.J Int Med Res1976https://conductscience.org/library/papers/1026535PubMed
31,150,784Determination of disopyramide and its mono-N-dealkylated metabolite in blood serum and urine.J Chromatogr1975https://conductscience.org/library/papers/1150784PubMed
41,026,537Anti-arrhythmic and haemodynamic effects of intravenous and oral disopyramide in patients with ventricular arrhythmia.J Int Med Res1976https://conductscience.org/library/papers/1026537PubMed
51,090,217The pharmacokinetics of Norpace.Angiology1975https://conductscience.org/library/papers/1090217PubMed
61,026,527Circulatory effects of intravenous disopyramide in heart failure.J Int Med Res1976https://conductscience.org/library/papers/1026527PubMed
71,026,536The use of disopyramide in the treatment of arrhythmias in ambulatory patients.J Int Med Res1976https://conductscience.org/library/papers/1026536PubMed
822,216,514The influence of pH on the buccal absorption and renal excretion of disopyramide in man.Br J Clin Pharmacol1976https://conductscience.org/library/papers/22216514PubMed
91,026,528Haemodynamics of intravenous disopyramide.J Int Med Res1976https://conductscience.org/library/papers/1026528PubMed
1054,578Oral disopyramide in prophylaxis of arrhythmias following myocardial infarction.Lancet1976https://conductscience.org/library/papers/54578PubMed

1 to 10 of 21

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Cited by31

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 81 citations.

PMIDTitleJournalYearIn PapersSource
12,844,326Therapeutic drug monitoring of antiarrhythmic drugs.Clin Pharmacokinet2003https://conductscience.org/library/papers/12844326PubMed
9,803,978Therapeutic drug monitoring: antiarrhythmic drugs.Br J Clin Pharmacol1998https://conductscience.org/library/papers/9803978PubMed
7,426,277Failure of alkaline diuresis to enhance diflunisal elimination.Br J Clin Pharmacol1980https://conductscience.org/library/papers/7426277PubMed
7,387,819Plasma binding of disopyramide.Br J Clin Pharmacol1980https://conductscience.org/library/papers/7387819PubMed
7,213,529The effect of enzyme induction on the metabolism of disopyramide in man.Br J Clin Pharmacol1981https://conductscience.org/library/papers/7213529PubMed
7,151,851The influence of protein binding on disopyramide clearance.Eur J Clin Pharmacol1982https://conductscience.org/library/papers/7151851PubMed
7,138,747Plasma binding of disopyramide and mono-N-dealkyldisopyramide.Br J Clin Pharmacol1982https://conductscience.org/library/papers/7138747PubMed
7,069,575The effect of saturable binding to plasma proteins on the pharmacokinetic properties of disopyramide.J Pharmacokinet Biopharm1982https://conductscience.org/library/papers/7069575PubMed
7,023,712Dose-dependent pharmacokinetics and cancer chemotherapy.Cancer Chemother Pharmacol1981https://conductscience.org/library/papers/7023712PubMed
7,016,383Pharmacokinetics of drug overdose.Clin Pharmacokinet1981https://conductscience.org/library/papers/7016383PubMed

1 to 10 of 31

See all 31 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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