Paper2117635
A single pre-B cell can give rise to antigen-specific B cells that utilize distinct immunoglobulin gene rearrangements.
Caton AJ. J Exp Med, 1990. Cited by 20 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
Download JSON
Cite this record
ConductScience Library. A single pre-B cell can give rise to antigen-specific B cells that utilize distinct immunoglobulin gene rearrangements. Papers, record 2117635. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2117635
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- A single pre-B cell can give rise to antigen-specific B cells that utilize distinct immunoglobulin gene rearrangements.
- PubMed
Topics17
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| B-Lymphocytes | Major topic |
| Gene Rearrangement | Major topic |
| Genes, Immunoglobulin | Major topic |
| Immunoglobulin Variable Region | Major topic |
| Alleles | |
| Amino Acid Sequence | |
| Animals | |
| Base Sequence | |
| Blotting, Southern | |
| DNA Probes | |
| Hybridomas | |
| Immunoglobulin Heavy Chains | |
| Immunoglobulin J-Chains | |
| Mice | |
| Mice, Inbred BALB C | |
| Molecular Sequence Data | |
| Restriction Mapping |
Source PubMed
Grants3
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by | Source |
|---|---|---|---|---|---|
| AI-24541 | NIAID NIH HHS | United States | R01AI024541 | PubMed and NIH | NIH RePORTER |
| R55AI024541 | NIH | NIH RePORTER | |||
| R56AI024541 | NIH | NIH RePORTER |
References40
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 6,798,155 | Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments. | J Exp Med | 1982 | https://conductscience.org/library/papers/6798155 | PubMed |
| 2 | 4,159,057 | Cellular localization of immunoglobulins with different allotypic specificities in rabbit lymphoid tissues. | J Exp Med | 1965 | https://conductscience.org/library/papers/4159057 | PubMed |
| 3 | 5,435,789 | Distribution of allotypic specificities A1, A2, A14, and A15 among immunoglobulin G molecules. | J Immunol | 1970 | https://conductscience.org/library/papers/5435789 | PubMed |
| 4 | 5,442,171 | Association of allotypic specificities of group a with allotypic specificities A11 and A12 in rabbit immunoglobulin. | Biochemistry | 1970 | https://conductscience.org/library/papers/5442171 | PubMed |
| 5 | 1,195,397 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | J Mol Biol | 1975 | https://conductscience.org/library/papers/1195397 | PubMed |
| 6 | 96,180 | Pre-B cells: bone marrow persistence in anti-mu-suppressed mice, conversion to B lymphocytes, and recovery after destruction by cyclophosphamide. | J Immunol | 1978 | https://conductscience.org/library/papers/96180 | PubMed |
| 7 | 6,775,817 | 5' flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains. | Cell | 1980 | https://conductscience.org/library/papers/6775817 | PubMed |
| 8 | 6,804,938 | DNA between variable and joining gene segments of immunoglobulin kappa light chain is frequently retained in cells that rearrange the kappa locus. | Proc Natl Acad Sci U S A | 1982 | https://conductscience.org/library/papers/6804938 | PubMed |
| 9 | 6,287,467 | Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. | Proc Natl Acad Sci U S A | 1982 | https://conductscience.org/library/papers/6287467 | PubMed |
| 10 | 6,291,785 | Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus. | Cell | 1982 | https://conductscience.org/library/papers/6291785 | PubMed |
| 11 | 6,600,489 | Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. I. Significant variation in repertoire expression between individual mice. | J Exp Med | 1983 | https://conductscience.org/library/papers/6600489 | PubMed |
| 12 | 6,308,665 | Recombination between antibody heavy chain variable-region genes: evidence for gene conversion. | Proc Natl Acad Sci U S A | 1983 | https://conductscience.org/library/papers/6308665 | PubMed |
| 13 | 6,420,335 | Pre-B cells in bone marrow: size distribution profile, proliferative capacity and peanut agglutinin binding of cytoplasmic mu chain-bearing cell populations in normal and regenerating bone marrow. | Immunology | 1984 | https://conductscience.org/library/papers/6420335 | PubMed |
| 14 | 6,546,718 | Evolution of a multigene family of V kappa germ line genes. | EMBO J | 1984 | https://conductscience.org/library/papers/6546718 | PubMed |
| 15 | 6,324,199 | kappa gene diversity among the clonal progeny of pre-B lymphocytes. | Proc Natl Acad Sci U S A | 1984 | https://conductscience.org/library/papers/6324199 | PubMed |
| 16 | 6,425,827 | Somatic diversification of immunoglobulins. | Proc Natl Acad Sci U S A | 1984 | https://conductscience.org/library/papers/6425827 | PubMed |
| 17 | 6,328,416 | Immunoglobulin gene 'remnant' DNA--implications for antibody gene recombination. | Nucleic Acids Res | 1984 | https://conductscience.org/library/papers/6328416 | PubMed |
| 18 | 6,203,114 | Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. | Proc Natl Acad Sci U S A | 1984 | https://conductscience.org/library/papers/6203114 | PubMed |
| 19 | 3,920,342 | Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin. | J Exp Med | 1985 | https://conductscience.org/library/papers/3920342 | PubMed |
| 20 | 3,920,529 | Transmission and expression of a specific pair of rearranged immunoglobulin mu and kappa genes in a transgenic mouse line. | Nature | 1985 | https://conductscience.org/library/papers/3920529 | PubMed |
Cited by8
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 20 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 27,356,897 | Flow Cytometric and Cytokine ELISpot Approaches To Characterize the Cell-Mediated Immune Response in Ferrets following Influenza Virus Infection. | J Virol | 2016 | https://conductscience.org/library/papers/27356897 | PubMed |
| 10,562,316 | Restricted immunoglobulin variable region (Ig V) gene expression accompanies secondary rearrangements of light chain Ig V genes in mouse plasmacytomas. | J Exp Med | 1999 | https://conductscience.org/library/papers/10562316 | PubMed |
| 8,514,881 | Restricted immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular polysaccharide. Nucleotide sequences of monospecific anti-Haemophilus antibodies and polyspecific antibodies cross-reacting with self antigens. | J Clin Invest | 1993 | https://conductscience.org/library/papers/8514881 | PubMed |
| 8,478,611 | Restricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinations. | J Exp Med | 1993 | https://conductscience.org/library/papers/8478611 | PubMed |
| 8,436,417 | Characterization of a V kappa family in Mus musculus castaneus: sequence analysis. | Immunogenetics | 1993 | https://conductscience.org/library/papers/8436417 | PubMed |
| 8,436,416 | Characterization of a V kappa family in Mus musculus castaneus: expansion at the subset level. | Immunogenetics | 1993 | https://conductscience.org/library/papers/8436416 | PubMed |
| 1,676,047 | The mouse antibody response to infection with Cryptococcus neoformans: VH and VL usage in polysaccharide binding antibodies. | J Exp Med | 1991 | https://conductscience.org/library/papers/1676047 | PubMed |
| 1,537,338 | Enrichment and characterization of uncommitted B-cell precursors from fetal liver at day 12 of gestation. | EMBO J | 1992 | https://conductscience.org/library/papers/1537338 | PubMed |
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
None in this release
- Trials
- Comments and corrections
- Genes
- Drugs
- Data
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this paper from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/papers/v1/2117635
GET https://conductscience.org/api/papers/v1/2117635/references?page=2