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Paper · 21531334

The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon.

Donohoe DR and 6 others. Cell Metab, 2011. Cited by 1,511 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Papers, record 21531334. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/21531334

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon.
PubMed
Journal
Cell Metab
PubMed
Year
2011
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
1,511
iCite
Relative citation ratio, by iCite
42
iCite
Revised in PubMed
2025-05-29
PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Donohoe DRDallas R
2Garge NNikhil
3Zhang XXinxin
4Sun WWei
5O'Connell TMThomas M
6Bunger MKMaureen K
7Bultman SJScott J

Source PubMed

Topics25

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AutophagyMajor topic
ButyratesMajor topic
ColonMajor topic
Energy MetabolismMajor topic
MetagenomeMajor topic
AMP-Activated Protein Kinases
Animals
Biomarkers
Blotting, Western
Cells, Cultured
Cyclin-Dependent Kinase Inhibitor p27
Gene Expression Profiling
Germ-Free Life
Glucose
Magnetic Resonance Spectroscopy
Male
Metabolomics
Mice
Mice, Inbred C57BL
Mitochondria
NAD
Oligonucleotide Array Sequence Analysis
Oxidative Phosphorylation
Phosphorylation
Signal Transduction

Source PubMed

Grants7

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
CA125237NCI NIH HHSUnited StatesR01CA125237PubMed and NIHNIH RePORTER
P30 ES010126NIEHS NIH HHSUnited StatesP30ES010126PubMed and NIHNIH RePORTER
R01 CA125237NCI NIH HHSUnited StatesR01CA125237PubMed and NIHNIH RePORTER
P30 DK034987NIDDK NIH HHSUnited StatesP30DK034987PubMed and NIHNIH RePORTER
P30 DK 34987NIDDK NIH HHSUnited StatesP30DK034987PubMed and NIHNIH RePORTER
P40RRO118603PHS HHSUnited StatesPubMedPubMed
P30-ES10126NIEHS NIH HHSUnited StatesP30ES010126PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in21,531,329The microbial-mammalian metabolic axis: beyond simple metabolism.https://conductscience.org/library/papers/21531329

Source PubMed

References47

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
118,551,400Identifying differences in protein expression levels by spectral counting and feature selection.Genet Mol Res2008https://conductscience.org/library/papers/18551400PubMed
217,210,919Mechanisms underlying the resistance to diet-induced obesity in germ-free mice.Proc Natl Acad Sci U S A2007https://conductscience.org/library/papers/17210919PubMed
315,070,763Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota.Proc Natl Acad Sci U S A2004https://conductscience.org/library/papers/15070763PubMed
420,033,346Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8.J Gastrointest Surg2010https://conductscience.org/library/papers/20033346PubMed
5468,074Method of preparing isolated colonic epithelial cells (colonocytes) for metabolic studies.Gut1979https://conductscience.org/library/papers/468074PubMed
6334,036Microbial ecology of the gastrointestinal tract.Annu Rev Microbiol1977https://conductscience.org/library/papers/334036PubMed
717,916,580Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes.DNA Res2007https://conductscience.org/library/papers/17916580PubMed
817,943,116The human microbiome project.Nature2007https://conductscience.org/library/papers/17943116PubMed
910,382,263Alternative schemes of butyrate production in Butyrivibrio fibrisolvens and their relationship to acetate utilization, lactate production, and phylogeny.Arch Microbiol1999https://conductscience.org/library/papers/10382263PubMed
1019,549,860Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation.Proc Natl Acad Sci U S A2009https://conductscience.org/library/papers/19549860PubMed

1 to 10 of 47

See all 47 references

Cited by1,086

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,511 citations.

PMIDTitleJournalYearIn PapersSource
42,953,207Natural products regulate gut microbiota and SCFA metabolism in IBD: mechanisms and therapeutic potential.Front Microbiol2026https://conductscience.org/library/papers/42953207PubMed
42,948,378From dietary exposure to organ injury: microbiome-mediated biotransformation of food-chain xenobiotics across the gut-liver-kidney axis.Front Microbiol2026https://conductscience.org/library/papers/42948378PubMed
42,943,797Natural Compounds and Their Microbiota-Derived Metabolites as Modulators of the Microbiota-Gut-Brain Axis in Alzheimer Disease: Biochemical Mechanisms and Drug Discovery Insights-A Narrative Review.Molecules2026https://conductscience.org/library/papers/42943797PubMed
42,940,310Eggshell Membrane in Gut Health: Processing-Dependent Redox, Barrier, Immune, and Microbiome Effects.Foods2026https://conductscience.org/library/papers/42940310PubMed
42,939,876Dietary Sodium Butyrate Alleviates Thiram-Induced Tibial Dyschondroplasia in Broilers by Improving Redox Homeostasis and Upregulating the Nrf2/HO-1 Pathway.Antioxidants (Basel)2026https://conductscience.org/library/papers/42939876PubMed
42,939,828Gut Microbiota-Host Redox Crosstalk: Molecular Mechanisms, Disease Pathogenesis, and Therapeutic Interventions.Antioxidants (Basel)2026https://conductscience.org/library/papers/42939828PubMed
42,929,808The Vaginal Microbiome-Mitochondria Axis: Implications for Genital Tract Infections.Cells2026https://conductscience.org/library/papers/42929808PubMed
42,910,076Dietary Butyrate as a Functional Feed Additive in Aquaculture: A Systematic Review and Meta-Analysis of Immunological and Antioxidant Responses With Dose-Response Insights.Aquac Nutr2026https://conductscience.org/library/papers/42910076PubMed
42,891,375Mitochondria-Macrophage Interactions in Sepsis at Different Immune Stages: Integrating Immunometabolic Reprogramming, Organ Damage, and Therapeutic Strategies.J Inflamm Res2026https://conductscience.org/library/papers/42891375PubMed
42,883,044Gut Microbiota-Mucosal Immune Interactions Underlying Intestinal Homeostasis in Weaned Piglets.Animals (Basel)2026https://conductscience.org/library/papers/42883044PubMed

1 to 10 of 1,086

See all 1,086 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccession
GEOGSE27590

Source GEO

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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