Paper · 2153235

Involvement of topoisomerases in replication, transcription, and packaging of the linear adenovirus genome.

Wong ML and 1 other. J Virol, 1990. Cited by 34 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Involvement of topoisomerases in replication, transcription, and packaging of the linear adenovirus genome. Papers, record 2153235. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2153235

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Involvement of topoisomerases in replication, transcription, and packaging of the linear adenovirus genome.; PubMed
Journal: J Virol; PubMed
Year: 1990; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/2153235/; PubMed
DOI: https://doi.org/10.1128/jvi.64.2.691-699.1990; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC249162/; PubMed
The journal: https://conductscience.org/library/journal-index/0113724; PubMed
Citations, by iCite: 34; iCite
Relative citation ratio, by iCite: 0.75; iCite
Revised in PubMed: 2020-07-24; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Wong ML	M L
2	Hsu MT	M T

Source PubMed

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Adenoviruses, Human	Major topic
Alkaloids	Major topic
Camptothecin	Major topic
DNA Replication	Major topic
DNA Topoisomerases, Type I	Major topic
DNA Topoisomerases, Type II	Major topic
Ellipticines	Major topic
Etoposide	Major topic
Transcription, Genetic	Major topic
Blotting, Southern
Cell Nucleus
DNA, Viral
Deoxyribonucleoproteins
Electrophoresis, Gel, Two-Dimensional
Electrophoresis, Polyacrylamide Gel
HeLa Cells
Humans
Microscopy, Electron
Templates, Genetic
Topoisomerase I Inhibitors
Topoisomerase II Inhibitors

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References35

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	3,002,631	Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites.	Cell	1986	https://conductscience.org/library/papers/3002631	PubMed
2	2,986,841	In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin.	Cell	1985	https://conductscience.org/library/papers/2986841	PubMed
3	3,002,439	Effects of DNA intercalating agents on topoisomerase II induced DNA strand cleavage in isolated mammalian cell nuclei.	Biochemistry	1985	https://conductscience.org/library/papers/3002439	PubMed
4	2,997,227	Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.	J Biol Chem	1985	https://conductscience.org/library/papers/2997227	PubMed
5	597,856	The structure of replicating adenovirus 2 DNA molecules.	Cell	1977	https://conductscience.org/library/papers/597856	PubMed
6	2,152,835	Topoisomerase I and II cleavage of adenovirus DNA in vivo: both topoisomerase activities appear to be required for adenovirus DNA replication.	J Virol	1990	https://conductscience.org/library/papers/2152835	PubMed
7	6,097,803	Biology of bacterial deoxyribonucleic acid topoisomerases.	Microbiol Rev	1984	https://conductscience.org/library/papers/6097803	PubMed
8	372,560	Involvement of DNA gyrase in replication and transcription of bacteriophage T7 DNA.	J Virol	1979	https://conductscience.org/library/papers/372560	PubMed
9	6,308,611	Adenovirus DNA replication in vitro: synthesis of full-length DNA with purified proteins.	Proc Natl Acad Sci U S A	1983	https://conductscience.org/library/papers/6308611	PubMed
10	2,823,264	Identification of a vaccinia virus gene encoding a type I DNA topoisomerase.	Proc Natl Acad Sci U S A	1987	https://conductscience.org/library/papers/2823264	PubMed

1 to 10 of 35

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Cited by12

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 34 citations.

PMID	Title	Journal	Year	In Papers	Source
41,481,430	Differential roles of type I topoisomerases in regulating HPV pathogenesis.	Proc Natl Acad Sci U S A	2026	https://conductscience.org/library/papers/41481430	PubMed
37,351,013	Human adenovirus DNA polymerase is evolutionarily and functionally associated with human telomerase reverse transcriptase based on in silico molecular characterization that implicate abacavir and zidovudine.	Front Bioinform	2023	https://conductscience.org/library/papers/37351013	PubMed
36,296,290	Antiviral Drugs in Adenovirus-Induced Keratoconjunctivitis.	Microorganisms	2022	https://conductscience.org/library/papers/36296290	PubMed
36,091,031	Current clinical landscape of oncolytic viruses as novel cancer immunotherapeutic and recent preclinical advancements.	Front Immunol	2022	https://conductscience.org/library/papers/36091031	PubMed
33,993,458	Topoisomerase II β Gene Specific siRNA Delivery by Nanoparticles Prepared with c-ter Apotransferrin and its Effect on HIV-1 Replication.	Mol Biotechnol	2021	https://conductscience.org/library/papers/33993458	PubMed
30,867,306	Cellular DNA Topoisomerases Are Required for the Synthesis of Hepatitis B Virus Covalently Closed Circular DNA.	J Virol	2019	https://conductscience.org/library/papers/30867306	PubMed
15,729,367	Gene-directed enzyme prodrug therapy with carboxylesterase enhances the anticancer efficacy of the conditionally replicating adenovirus AdDelta24.	Gene Ther	2005	https://conductscience.org/library/papers/15729367	PubMed
7,884,854	An etoposide-induced block in vaccinia virus telomere resolution is dependent on the virus-encoded DNA ligase.	J Virol	1995	https://conductscience.org/library/papers/7884854	PubMed
7,615,831	T cell proliferative response induced by DNA topoisomerase I in patients with systemic sclerosis and healthy donors.	J Clin Invest	1995	https://conductscience.org/library/papers/7615831	PubMed
7,539,924	Human immunodeficiency virus type 1 reverse transcriptase: enhancement of activity by interaction with cellular topoisomerase I.	Proc Natl Acad Sci U S A	1995	https://conductscience.org/library/papers/7539924	PubMed

1 to 10 of 12

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
TOP2A	7,153	PubTator's text mining	https://conductscience.org/library/genes/7153

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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