Paper · 21550

Cyclic AMP and contractile activity in heart.

Tsien RW. Adv Cyclic Nucleotide Res, 1977. Cited by 263 papers, by iCite.

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ConductScience Library. Cyclic AMP and contractile activity in heart. Papers, record 21550. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/21550

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Cyclic AMP and contractile activity in heart.; PubMed
Journal: Adv Cyclic Nucleotide Res; PubMed
Year: 1977; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S., Review; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/21550/; PubMed
The journal: https://conductscience.org/library/journal-index/0341362; PubMed
Citations, by iCite: 263; iCite
Relative citation ratio, by iCite: 8.52; iCite
Revised in PubMed: 2013-11-21; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Tsien RW	R W

Source PubMed

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Cyclic AMP	Major topic
Myocardial Contraction	Major topic
Action Potentials
Adrenergic beta-Agonists
Animals
Biological Transport, Active
Bucladesine
Calcium
Catecholamines
Fluorides
Glucagon
Imidazoles
Isoproterenol
Kinetics
Methods
Myocardium
Papaverine
Phosphorylases
Protein Kinases
Receptors, Adrenergic, beta
Xanthines

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by96

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 263 citations.

PMID	Title	Journal	Year	In Papers	Source
36,142,518	The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic Approaches.	Int J Mol Sci	2022	https://conductscience.org/library/papers/36142518	PubMed
24,583,770	Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.	Physiology (Bethesda)	2014	https://conductscience.org/library/papers/24583770	PubMed
14,619,950	Regulation of L-type Ca2+ channels in the heart: overview of recent advances.	Mol Cell Biochem	2003	https://conductscience.org/library/papers/14619950	PubMed
12,871,825	Muscarinic regulation of cardiac ion channels.	Br J Pharmacol	2003	https://conductscience.org/library/papers/12871825	PubMed
12,840,845	The effects of Radix Ginseng rubra on cAMP of experimental ischemic myocardium in rats.	J Tongji Med Univ	1999	https://conductscience.org/library/papers/12840845	PubMed
12,595,951	New milrinone analogues: in vitro study of structure-activity relationships for positive inotropic effect, antagonism towards endogenous adenosine, and inhibition of cardiac type III phosphodiesterase.	Naunyn Schmiedebergs Arch Pharmacol	2003	https://conductscience.org/library/papers/12595951	PubMed
10,990,533	L-type Ca2+ current as the predominant pathway of Ca2+ entry during I(Na) activation in beta-stimulated cardiac myocytes.	J Physiol	2000	https://conductscience.org/library/papers/10990533	PubMed
9,423,181	Sarcoplasmic reticulum Ca2+ content, L-type Ca2+ current and the Ca2+ transient in rat myocytes during beta-adrenergic stimulation.	J Physiol	1997	https://conductscience.org/library/papers/9423181	PubMed
8,804,607	Modulating L-type calcium current affects discontinuous cardiac action potential conduction.	Biophys J	1996	https://conductscience.org/library/papers/8804607	PubMed
8,401,934	Induction by endogenous noradrenaline of an alpha 1-adrenoceptor-mediated positive inotropic effect in rabbit papillary muscles.	Br J Pharmacol	1993	https://conductscience.org/library/papers/8401934	PubMed

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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