Paper · 22258607

The DNA damage response and cancer therapy.

Lord CJ and 1 other. Nature, 2012. Cited by 1,428 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The DNA damage response and cancer therapy. Papers, record 22258607. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/22258607

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The DNA damage response and cancer therapy.; PubMed
Journal: Nature; PubMed
Year: 2012; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Review; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/22258607/; PubMed
DOI: https://doi.org/10.1038/nature10760; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 1,428; iCite
Relative citation ratio, by iCite: 35.2; iCite
Revised in PubMed: 2025-05-29; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Lord CJ	Christopher J
2	Ashworth A	Alan

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
DNA Damage	Major topic
Neoplasms	Major topic
DNA Repair
Genomic Instability
Humans
Molecular Targeted Therapy
Neoplastic Stem Cells
Poly(ADP-ribose) Polymerase Inhibitors
Poly(ADP-ribose) Polymerases
Tumor Microenvironment

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	Stated by
BREAST CANCER NOW RESEARCH CENTRE	Breast Cancer Now	United Kingdom	PubMed
	Wellcome Trust	United Kingdom	PubMed
	Cancer Research UK	United Kingdom	PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References71

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	9,353,181	Integrating genetic approaches into the discovery of anticancer drugs.	Science	1997	https://conductscience.org/library/papers/9353181	PubMed
2	21,376,230	Hallmarks of cancer: the next generation.	Cell	2011	https://conductscience.org/library/papers/21376230	PubMed
3	21,575,865	Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.	Cancer Cell	2011	https://conductscience.org/library/papers/21575865	PubMed
4	15,829,967	Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.	Nature	2005	https://conductscience.org/library/papers/15829967	PubMed
5	5,683,639	Synthetic lethality and semi-lethality among functionally related mutants of Drosophila melanfgaster.	Genetics	1968	https://conductscience.org/library/papers/5683639	PubMed
6	19,809,470	Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity.	Nat Rev Genet	2009	https://conductscience.org/library/papers/19809470	PubMed
7	7,669,074	Potential chemotherapeutic activity of 4-iodo-3-nitrobenzamide. Metabolic reduction to the 3-nitroso derivative and induction of cell death in tumor cells in culture.	Biochem Pharmacol	1995	https://conductscience.org/library/papers/7669074	PubMed
8	20,700,108	Making the best of PARP inhibitors in ovarian cancer.	Nat Rev Clin Oncol	2010	https://conductscience.org/library/papers/20700108	PubMed
9	20,368,722	NHEJ and its backup pathways in chromosomal translocations.	Nat Struct Mol Biol	2010	https://conductscience.org/library/papers/20368722	PubMed
10	19,654,294	Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma.	Cancer Res	2009	https://conductscience.org/library/papers/19654294	PubMed

1 to 10 of 71

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Cited by946

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,428 citations.

PMID	Title	Journal	Year	In Papers	Source
42,949,705	Label-free Raman spectroscopy for cancer therapy response: from methodological framework to clinical translation.	Chem Soc Rev	2026	https://conductscience.org/library/papers/42949705	PubMed
42,929,827	Chromosomal Radiosensitivity in Sjögren's Syndrome with and Without Concomitant Malignancy.	Cells	2026	https://conductscience.org/library/papers/42929827	PubMed
42,900,451	The role of the mitochondrial phosphate carrier in modulating mitochondrial homeostasis and enhancing radiosensitivity in tumor cells.	Mol Biol Rep	2026	https://conductscience.org/library/papers/42900451	PubMed
42,891,339	Microbiome-pancreatic cancer crosstalk: From tumor biology to therapeutic intervention.	IMetaOmics	2026	https://conductscience.org/library/papers/42891339	PubMed
42,846,438	Xeroderma Pigmentosum Monozygotic Twins: Same Mutation Divergent Clinical Outcomes.	Hum Mutat	2026	https://conductscience.org/library/papers/42846438	PubMed
42,829,370	From initial complete response to recurrence: ENPP1 mutation drives cisplatin resistance through STING/NF-κB/IL-6 axis in hypopharyngeal squamous cell carcinoma.	Br J Cancer	2026	https://conductscience.org/library/papers/42829370	PubMed
42,807,681	Gut microbiota-mediated chemotherapy resistance in colorectal cancer: mechanisms and precision interventions.	Front Oncol	2026	https://conductscience.org/library/papers/42807681	PubMed
42,794,515	Special Issue 'Molecular Mechanisms and New Markers of Cancer'-From Static Biomarkers to Context-Aware Precision Oncology.	Int J Mol Sci	2026	https://conductscience.org/library/papers/42794515	PubMed
42,781,243	Targeting the DNA Damage Response in Cancer.	MedComm (2020)	2026	https://conductscience.org/library/papers/42781243	PubMed
42,761,377	Mechanism-guided radiosensitization strategies for nasopharyngeal carcinoma: Current evidence and translational perspectives (Review).	Oncol Lett	2026	https://conductscience.org/library/papers/42761377	PubMed

1 to 10 of 946

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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