Paper · 225671

Single strands induce recA protein to unwind duplex DNA for homologous pairing.

Cunningham RP and 3 others. Nature, 1979. Cited by 145 papers, by iCite.

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ConductScience Library. Single strands induce recA protein to unwind duplex DNA for homologous pairing. Papers, record 225671. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/225671

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Single strands induce recA protein to unwind duplex DNA for homologous pairing.; PubMed
Journal: Nature; PubMed
Year: 1979; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/225671/; PubMed
DOI: https://doi.org/10.1038/281191a0; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 145; iCite
Relative citation ratio, by iCite: 3.27; iCite
Revised in PubMed: 2019-06-17; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Cunningham RP	R P
2	Shibata T	T
3	DasGupta C	C
4	Radding CM	C M

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
DNA Helicases	Major topic
DNA, Single-Stranded	Major topic
Recombination, Genetic	Major topic
Adenosine Triphosphate
Coliphages
DNA Ligases
DNA Topoisomerases, Type I
DNA, Superhelical
DNA, Viral
Nucleic Acid Conformation

Source PubMed

Grants0

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None in this release.

Trials0

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None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by46

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 145 citations.

PMID	Title	Journal	Year	In Papers	Source
38,214,227	Homology recognition without double-stranded DNA-strand separation in D-loop formation by RecA.	Nucleic Acids Res	2024	https://conductscience.org/library/papers/38214227	PubMed
33,294,131	The intrinsic ability of double-stranded DNA to carry out D-loop and R-loop formation.	Comput Struct Biotechnol J	2020	https://conductscience.org/library/papers/33294131	PubMed
27,129,270	DNA Sequence Alignment during Homologous Recombination.	J Biol Chem	2016	https://conductscience.org/library/papers/27129270	PubMed
26,003,632	RecBCD is required to complete chromosomal replication: Implications for double-strand break frequencies and repair mechanisms.	DNA Repair (Amst)	2015	https://conductscience.org/library/papers/26003632	PubMed
19,729,448	A non-canonical DNA structure enables homologous recombination in various genetic systems.	J Biol Chem	2009	https://conductscience.org/library/papers/19729448	PubMed
14,672,976	Fluorescent detection and isolation of DNA variants using stabilized RecA-coated oligonucleotides.	Genome Res	2004	https://conductscience.org/library/papers/14672976	PubMed
12,702,672	Conjugational hyperrecombination achieved by derepressing the LexA regulon, altering the properties of RecA protein and inactivating mismatch repair in Escherichia coli K-12.	Genetics	2003	https://conductscience.org/library/papers/12702672	PubMed
11,459,989	The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA.	Proc Natl Acad Sci U S A	2001	https://conductscience.org/library/papers/11459989	PubMed
10,585,965	Recombinational repair of DNA damage in Escherichia coli and bacteriophage lambda.	Microbiol Mol Biol Rev	1999	https://conductscience.org/library/papers/10585965	PubMed
10,444,598	A novel property of the RecA nucleoprotein filament: activation of double- stranded DNA for strand exchange in trans.	Genes Dev	1999	https://conductscience.org/library/papers/10444598	PubMed

1 to 10 of 46

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Genes0

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None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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