Paper232189
Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate.
Furman PA and 5 others. J Virol, 1979. Cited by 289 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
Download JSON
Cite this record
ConductScience Library. Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate. Papers, record 232189. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/232189
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate.
- PubMed
Topics13
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| DNA Replication | Major topic |
| DNA, Viral | Major topic |
| Guanine Nucleotides | Major topic |
| Guanosine | Major topic |
| Nucleic Acid Synthesis Inhibitors | Major topic |
| Simplexvirus | Major topic |
| Animals | |
| Cell Line | |
| DNA | |
| DNA-Directed DNA Polymerase | |
| Haplorhini | |
| Kidney | |
| Templates, Genetic |
Source PubMed
References20
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 202,961 | Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. | Proc Natl Acad Sci U S A | 1977 | https://conductscience.org/library/papers/202961 | PubMed |
| 2 | 216,993 | Erythro-9-(2-hydroxy-3-nonyl)adenine as a specific inhibitor of herpes simplex virus replication in the presence and absence of adenosine analogues. | Proc Natl Acad Sci U S A | 1978 | https://conductscience.org/library/papers/216993 | PubMed |
| 3 | 214,430 | Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine. | J Biol Chem | 1978 | https://conductscience.org/library/papers/214430 | PubMed |
| 4 | 205,792 | 9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group. | Nature | 1978 | https://conductscience.org/library/papers/205792 | PubMed |
| 5 | 185,944 | Antiviral action and cellular toxicity of four thymidine analogues: 5-ethyl-,5-vinyl-, 5-propyl-, and 5-allyl-2'- deoxyuridine. | Antimicrob Agents Chemother | 1976 | https://conductscience.org/library/papers/185944 | PubMed |
| 6 | 280,147 | Relative potencies of anti-herpes compounds. | Ann N Y Acad Sci | 1977 | https://conductscience.org/library/papers/280147 | PubMed |
| 7 | 4,128,379 | Human cytomegalovirus. I. Purification and characterization of viral DNA. | J Virol | 1973 | https://conductscience.org/library/papers/4128379 | PubMed |
| 8 | 4,328,798 | Detection of Epstein-Barr viral genome in nonproductive cells. | Nat New Biol | 1971 | https://conductscience.org/library/papers/4328798 | PubMed |
| 9 | 4,329,966 | Size, composition, and structure of the deoxyribonucleic acid of herpes simplex virus subtypes 1 and 2. | J Virol | 1971 | https://conductscience.org/library/papers/4329966 | PubMed |
| 10 | 4,354,205 | Characterization of herpes simplex virus-induced deoxyribonucleic acid polymerase. | J Biol Chem | 1973 | https://conductscience.org/library/papers/4354205 | PubMed |
| 11 | 4,312,461 | Enzymatic synthesis of deoxyribonucleic acid. XXXIV. Termination of chain growth by a 2',3'-dideoxyribonucleotide. | Biochemistry | 1969 | https://conductscience.org/library/papers/4312461 | PubMed |
| 12 | 4,551,521 | In vitro transcription of Escherichia coli ribosomal RNA genes. | Nature | 1972 | https://conductscience.org/library/papers/4551521 | PubMed |
| 13 | 167,186 | Selective inhibition of herpes simplex virus by 5-amino-2,5-dideoxy-5-iodouridine. | J Virol | 1975 | https://conductscience.org/library/papers/167186 | PubMed |
| 14 | 164,617 | Selective inhibition of the replication of herpes simplex virus by 5-halogenated analogues of deoxycytidine. | Mol Pharmacol | 1975 | https://conductscience.org/library/papers/164617 | PubMed |
| 15 | 167,520 | Inhibition of herpes simplex virus replication by araT. | Virology | 1975 | https://conductscience.org/library/papers/167520 | PubMed |
| 16 | 168,404 | Human cytomegalovirus. III. Virus-induced DNA polymerase. | J Virol | 1975 | https://conductscience.org/library/papers/168404 | PubMed |
| 17 | 4,986,558 | Pharmacology of viruses. | Annu Rev Pharmacol | 1970 | https://conductscience.org/library/papers/4986558 | PubMed |
| 18 | 942,051 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | Anal Biochem | 1976 | https://conductscience.org/library/papers/942051 | PubMed |
| 19 | 5,476,915 | Kinetics and intermediates in the intracellular synthesis of bacteriophage T4 deoxyribonucleic acid. | J Mol Biol | 1970 | https://conductscience.org/library/papers/5476915 | PubMed |
| 20 | 6,081,184 | A novel method for phosphorylation of nucleosides to 5'-nucleotides. | Tetrahedron Lett | 1967 | https://conductscience.org/library/papers/6081184 | PubMed |
Cited by87
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 289 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 40,728,975 | Valorization of a Natural Compound Library in Exploring Potential Marburg Virus VP35 Cofactor Inhibitors via an In Silico Drug Discovery Strategy. | Curr Issues Mol Biol | 2025 | https://conductscience.org/library/papers/40728975 | PubMed |
| 32,287,578 | Chapter 3 Antiviral drugs: general considerations. | Perspect Med Virol | 1985 | https://conductscience.org/library/papers/32287578 | PubMed |
| 31,934,661 | Anti-CyHV-3 Effect of Fluorescent, Tricyclic Derivative of Acyclovir 6-(4-MeOPh)-TACV in vitro. | J Vet Res | 2019 | https://conductscience.org/library/papers/31934661 | PubMed |
| 31,826,988 | RNA Polymerase II Promoter-Proximal Pausing and Release to Elongation Are Key Steps Regulating Herpes Simplex Virus 1 Transcription. | J Virol | 2020 | https://conductscience.org/library/papers/31826988 | PubMed |
| 30,075,555 | Retinitis associated with double infection of Epstein-Barr virus and varicella-zoster virus: A case report. | Medicine (Baltimore) | 2018 | https://conductscience.org/library/papers/30075555 | PubMed |
| 28,376,211 | Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma. | J Natl Cancer Inst | 2017 | https://conductscience.org/library/papers/28376211 | PubMed |
| 24,734,222 | N2-Phenyl-9-(hydroxyalkyl)guanines and related compounds are substrates for Herpes simplex virus thymidine kinases. | J Mol Biochem | 2012 | https://conductscience.org/library/papers/24734222 | PubMed |
| 23,791,977 | Turning an antiviral into an anticancer drug: nanoparticle delivery of acyclovir monophosphate. | J Control Release | 2013 | https://conductscience.org/library/papers/23791977 | PubMed |
| 22,581,427 | Direct evidence that HSV DNA damaged by ultraviolet (UV) irradiation can be repaired in a cell type-dependent manner. | J Neurovirol | 2012 | https://conductscience.org/library/papers/22581427 | PubMed |
| 21,234,082 | Topical Acyclovir for Recurrent Herpes Labialis in Primary Care: Critical appraisal. | Can Fam Physician | 1991 | https://conductscience.org/library/papers/21234082 | PubMed |
| 19,509,419 | Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase. | J Biol Chem | 2009 | https://conductscience.org/library/papers/19509419 | PubMed |
| 12,183,238 | Samarangenin B from Limonium sinense suppresses herpes simplex virus type 1 replication in Vero cells by regulation of viral macromolecular synthesis. | Antimicrob Agents Chemother | 2002 | https://conductscience.org/library/papers/12183238 | PubMed |
| 10,428,917 | Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein. | Antimicrob Agents Chemother | 1999 | https://conductscience.org/library/papers/10428917 | PubMed |
| 9,687,413 | Mode of action of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl) cycloprop-1'-yl]methyl]guanine (A-5021) against herpes simplex virus type 1 and type 2 and varicella-zoster virus. | Antimicrob Agents Chemother | 1998 | https://conductscience.org/library/papers/9687413 | PubMed |
| 9,661,001 | Antiherpesvirus activities of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine (A-5021) in cell culture. | Antimicrob Agents Chemother | 1998 | https://conductscience.org/library/papers/9661001 | PubMed |
| 9,151,871 | Herpes simplex virus type 1 prereplicative sites are a heterogeneous population: only a subset are likely to be precursors to replication compartments. | J Virol | 1997 | https://conductscience.org/library/papers/9151871 | PubMed |
| 8,814,744 | Randomised trial of ganciclovir and acyclovir in the treatment of herpes simplex dendritic keratitis: a multicentre study. | Br J Ophthalmol | 1996 | https://conductscience.org/library/papers/8814744 | PubMed |
| 8,648,670 | Targeting human immunodeficiency virus type 1 reverse transcriptase by intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle. | J Virol | 1996 | https://conductscience.org/library/papers/8648670 | PubMed |
| 8,629,950 | Identification and analysis of the simian varicella virus thymidine kinase gene. | Arch Virol | 1996 | https://conductscience.org/library/papers/8629950 | PubMed |
| 8,453,821 | Comparative pharmacokinetics of antiviral nucleoside analogues. | Clin Pharmacokinet | 1993 | https://conductscience.org/library/papers/8453821 | PubMed |
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
None in this release
- Grants
- Trials
- Comments and corrections
- Genes
- Drugs
- Data
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this paper from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/papers/v1/232189
GET https://conductscience.org/api/papers/v1/232189/cited_by?page=2