Paper · 23396013
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples.
Cibulskis K and 9 others. Nat Biotechnol, 2013. Cited by 3,967 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Papers, record 23396013. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/23396013
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples.
- PubMed
Topics10
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| DNA, Neoplasm | Major topic |
| High-Throughput Nucleotide Sequencing | Major topic |
| Neoplasms | Major topic |
| Point Mutation | Major topic |
| Bayes Theorem | |
| Genome, Human | |
| Heterozygote | |
| Humans | |
| Reproducibility of Results | |
| Sensitivity and Specificity |
Source PubMed
Grants4
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by | Source |
|---|---|---|---|---|---|
| U24 CA143845 | NCI NIH HHS | United States | U24CA143845 | PubMed and NIH | NIH RePORTER |
| U54 HG003067 | NHGRI NIH HHS | United States | U54HG003067 | PubMed and NIH | NIH RePORTER |
| U54HG003067 | NHGRI NIH HHS | United States | U54HG003067 | PubMed and NIH | NIH RePORTER |
| U24CA143845 | NCI NIH HHS | United States | U24CA143845 | PubMed and NIH | NIH RePORTER |
Trials3
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
| Trial | Title | The trial lists it as | Named in the paper's record | Source |
|---|---|---|---|---|
| NCT04273061 | Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity | Background | ClinicalTrials.gov | |
| NCT04812938 | Exploiting Pathogenic Tp53 Mutation for Early Diagnosis of Ovarian Cancer by Mean of Papanicolau Test | Results | ClinicalTrials.gov | |
| NCT04873427 | In Situ Clonal Heterogeneity in Prostatic Diagnostic Biopsies | Background | ClinicalTrials.gov |
Comments and corrections1
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
| Kind | PMID | Title | In Papers |
|---|---|---|---|
| Comment in | 23,653,923 | Bioinformatics: Tumors have their differences. | https://conductscience.org/library/papers/23653923 |
Source PubMed
References46
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 19,451,168 | Fast and accurate short read alignment with Burrows-Wheeler transform. | Bioinformatics | 2009 | https://conductscience.org/library/papers/19451168 | PubMed |
| 2 | 22,797,305 | A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers. | J Clin Invest | 2012 | https://conductscience.org/library/papers/22797305 | PubMed |
| 3 | 20,393,554 | International network of cancer genome projects. | Nature | 2010 | https://conductscience.org/library/papers/20393554 | PubMed |
| 4 | 22,385,957 | Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. | Cell | 2012 | https://conductscience.org/library/papers/22385957 | PubMed |
| 5 | 21,803,805 | ContEst: estimating cross-contamination of human samples in next-generation sequencing data. | Bioinformatics | 2011 | https://conductscience.org/library/papers/21803805 | PubMed |
| 6 | 21,430,775 | Initial genome sequencing and analysis of multiple myeloma. | Nature | 2011 | https://conductscience.org/library/papers/21430775 | PubMed |
| 7 | 22,385,958 | Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. | Cell | 2012 | https://conductscience.org/library/papers/22385958 | PubMed |
| 8 | 22,810,696 | Comprehensive molecular characterization of human colon and rectal cancer. | Nature | 2012 | https://conductscience.org/library/papers/22810696 | PubMed |
| 9 | 19,505,943 | The Sequence Alignment/Map format and SAMtools. | Bioinformatics | 2009 | https://conductscience.org/library/papers/19505943 | PubMed |
| 10 | 20,981,102 | Distant metastasis occurs late during the genetic evolution of pancreatic cancer. | Nature | 2010 | https://conductscience.org/library/papers/20981102 | PubMed |
1 to 10 of 46
See all 46 referencesCited by3,212
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 3,967 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,988,826 | Integrated genomic and transcriptomic profiling across the clinical spectrum of Lynch syndrome-associated endometrial disease. | NPJ Precis Oncol | 2026 | https://conductscience.org/library/papers/42988826 | PubMed |
| 42,983,544 | Improved detection of low-level GNAQ mosaicism in Sturge-Weber syndrome through affected tissue testing, deep sequencing, and HRM-qPCR. | Orphanet J Rare Dis | 2026 | https://conductscience.org/library/papers/42983544 | PubMed |
| 42,967,950 | A CCL21 gene-modified dendritic cell vaccine combined with pembrolizumab in advanced non-small cell lung cancer: a phase I trial. | Nat Commun | 2026 | https://conductscience.org/library/papers/42967950 | PubMed |
| 42,941,765 | Prediction of Tumor Complete Response Using Genomic and Clinical Data in Solid Cancer Undergoing Definitive Radiation Therapy. | Int J Mol Sci | 2026 | https://conductscience.org/library/papers/42941765 | PubMed |
| 42,928,626 | SomatiX: accurate and efficient somatic SNV detection from matched tumor-normal long-read DNA sequencing. | Bioinformatics | 2026 | https://conductscience.org/library/papers/42928626 | PubMed |
| 42,921,908 | RAS-Pathway Mutation Profiles and Clinical Outcomes Among Patients With Colorectal Cancer. | Cancer Med | 2026 | https://conductscience.org/library/papers/42921908 | PubMed |
| 42,911,976 | Multi-omics analysis of high-grade serous ovarian cancers reveals heterogeneity and distinct immunological patterns based upon clinico-genomic status. | PLoS Genet | 2026 | https://conductscience.org/library/papers/42911976 | PubMed |
| 42,902,030 | Small variant calling in the era of long-read sequencing. | Nat Rev Genet | 2026 | https://conductscience.org/library/papers/42902030 | PubMed |
| 42,879,006 | Germline Variation and Somatic Alterations in Ewing Sarcoma. | Methods Mol Biol | 2027 | https://conductscience.org/library/papers/42879006 | PubMed |
| 42,864,407 | Computational design and translational development of TCR-mimic scFv antibodies for peptide-HLA neoantigen targeting. | NPJ Drug Discov | 2026 | https://conductscience.org/library/papers/42864407 | PubMed |
1 to 10 of 3,212
See all 3,212 cited byGenes0
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
None in this release.
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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