Paper · 235474

An essential ionized acid group in sodium channels.

Hille B. Fed Proc, 1975. Cited by 59 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. An essential ionized acid group in sodium channels. Papers, record 235474. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/235474

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: An essential ionized acid group in sodium channels.; PubMed
Journal: Fed Proc; PubMed
Year: 1975; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/235474/; PubMed
The journal: https://conductscience.org/library/journal-index/0372771; PubMed
Citations, by iCite: 59; iCite
Relative citation ratio, by iCite: 2.01; iCite
Revised in PubMed: 2021-10-22; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Hille B	B

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Cell Membrane	Major topic
Neurons	Major topic
Sodium	Major topic
Binding Sites
Carboxylic Acids
Cell Membrane Permeability
Hydrogen-Ion Concentration
Models, Biological
Models, Chemical
Saxitoxin
Tetrodotoxin

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
R01 NS008174	NINDS NIH HHS	United States	R01NS008174	PubMed

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by19

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 59 citations.

PMID	Title	Journal	Year	In Papers	Source
30,131,702	Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies.	Front Pharmacol	2018	https://conductscience.org/library/papers/30131702	PubMed
23,008,436	Use-dependent block of the voltage-gated Na(+) channel by tetrodotoxin and saxitoxin: effect of pore mutations that change ionic selectivity.	J Gen Physiol	2012	https://conductscience.org/library/papers/23008436	PubMed
15,047,052	Gas-phase dissociation reactions of protonated saxitoxin and neosaxitoxin.	J Am Soc Mass Spectrom	2004	https://conductscience.org/library/papers/15047052	PubMed
8,384,241	Divalent cation competition with [3H]saxitoxin binding to tetrodotoxin-resistant and -sensitive sodium channels. A two-site structural model of ion/toxin interaction.	J Gen Physiol	1993	https://conductscience.org/library/papers/8384241	PubMed
6,965,988	Effect of external cation and anion substitutions on sodium transport in isolated frog skin.	J Membr Biol	1980	https://conductscience.org/library/papers/6965988	PubMed
6,334,164	Effects of chemical modification of carboxyl groups on the voltage-clamped nerve fiber of the frog.	J Membr Biol	1984	https://conductscience.org/library/papers/6334164	PubMed
6,308,126	Mn ions pass through calcium channels. A possible explanation.	J Gen Physiol	1983	https://conductscience.org/library/papers/6308126	PubMed
6,300,755	The permeability of sodium channels to hydrogen ions in nerve fibres.	Pflugers Arch	1983	https://conductscience.org/library/papers/6300755	PubMed
6,289,303	Electron microscopic visualization of the tetrodotoxin-binding protein from Electrophorus electricus.	Proc Natl Acad Sci U S A	1982	https://conductscience.org/library/papers/6289303	PubMed
1,262,852	Ionic selectivity of the sodium channel of frog skeletal muscle.	J Gen Physiol	1976	https://conductscience.org/library/papers/1262852	PubMed

1 to 10 of 19

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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