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Paper2367321

Estimate of volume/flow ratio of gastrointestinal (GI) fluids in humans using pharmacokinetic data.

Macheras P and 2 others. Pharm Res, 1990. Cited by 8 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Estimate of volume/flow ratio of gastrointestinal (GI) fluids in humans using pharmacokinetic data. Papers, record 2367321. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2367321

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Estimate of volume/flow ratio of gastrointestinal (GI) fluids in humans using pharmacokinetic data.
PubMed
Journal
Pharm Res
PubMed
Year
1990
PubMed
Publication types
Comparative Study, Journal Article
PubMed
Citations, by iCite
8
iCite
Relative citation ratio, by iCite
0.58
iCite
Revised in PubMed
2026-10-16
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Macheras PP
2Reppas CC
3Dressman JBJ B

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Body FluidsMajor topic
Digestive SystemMajor topic
Models, BiologicalMajor topic
PharmacokineticsMajor topic
Animals
Gastrointestinal Transit
Humans
Intestinal Absorption
Mathematical Computing
Rats

Source PubMed

References40

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
17,463,318Analysis of models for determining intestinal wall permeabilities.J Pharm Sci1980https://conductscience.org/library/papers/7463318PubMed
26,141,268Effect of food, fluid and dosage form on the absorption of 52-522, a potential antianxiety agent, in the dog.J Pharm Pharmacol1984https://conductscience.org/library/papers/6141268PubMed
32,923,960Toward a quantitative approach for the prediction of the fraction of dose absorbed using the absorption potential concept.Biopharm Drug Dispos1989https://conductscience.org/library/papers/2923960PubMed
46,355,048Pharmacokinetics of acyclovir after intravenous and oral administration.J Antimicrob Chemother1983https://conductscience.org/library/papers/6355048PubMed
57,253,676A convective mass transfer model for determining intestinal wall permeabilities: laminar flow in a circular tube.J Theor Biol1980https://conductscience.org/library/papers/7253676PubMed
66,852,464Regulation of the gastric emptying of glucose.Gastroenterology1983https://conductscience.org/library/papers/6852464PubMed
77,460,704Gastric emptying of varying meal weight and composition in man. Evaluation by dual liquid- and solid-phase isotopic method.Dig Dis Sci1981https://conductscience.org/library/papers/7460704PubMed
81,277,712Propoxyphene and norpropoxyphene: influence of diet and fluid on plasma levels.Clin Pharmacol Ther1976https://conductscience.org/library/papers/1277712PubMed
9856,000Bioavailability of tetracycline and doxycycline in fasted and nonfasted subjects.Antimicrob Agents Chemother1977https://conductscience.org/library/papers/856000PubMed
114,020,642Absorption potential: estimating the fraction absorbed for orally administered compounds.J Pharm Sci1985https://conductscience.org/library/papers/4020642PubMed
121,122,688Influence of diet and fluid on bioavailability of theophylline.Clin Pharmacol Ther1975https://conductscience.org/library/papers/1122688PubMed
134,479,714The pharmacokinetics of propylthiouracil.Acta Pharmacol Toxicol (Copenh)1974https://conductscience.org/library/papers/4479714PubMed
142,906,367Absolute bioavailability and dose proportionality of betaxolol in normal healthy subjects.J Pharm Sci1988https://conductscience.org/library/papers/2906367PubMed
154,005,111Investigation of drug absorption from the gastrointestinal tract of man. II. Metoprolol in the jejunum and ileum.Br J Clin Pharmacol1985https://conductscience.org/library/papers/4005111PubMed
163,244,618Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds.Pharm Res1988https://conductscience.org/library/papers/3244618PubMed
176,142,717Bioavailability of bromazepam in man after single administration of an oral solution.Arzneimittelforschung1984https://conductscience.org/library/papers/6142717PubMed
1815,094Shift of pH-absorption curves.J Pharmacokinet Biopharm1977https://conductscience.org/library/papers/15094PubMed
19660,450Bioavailability of erythromycin stearate: influence of food and fluid volume.J Pharm Sci1978https://conductscience.org/library/papers/660450PubMed
20620,910Bioavailability of cimetidine in man.Gastroenterology1978https://conductscience.org/library/papers/620910PubMed
216,491,914Pharmacokinetics of bumetanide following intravenous, intramuscular, and oral administrations to normal subjects.J Pharm Sci1984https://conductscience.org/library/papers/6491914PubMed

See all 40 references

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Cited by
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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