Paper239228

Intracellular pH and distribution of weak acids across cell membranes. A study of D- and L-lactate and of DMO in rat diaphragm.

Roos A. J Physiol, 1975. Cited by 118 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Intracellular pH and distribution of weak acids across cell membranes. A study of D- and L-lactate and of DMO in rat diaphragm. Papers, record 239228. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/239228

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Intracellular pH and distribution of weak acids across cell membranes. A study of D- and L-lactate and of DMO in rat diaphragm.; PubMed
Journal: J Physiol; PubMed
Year: 1975; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/239228/; PubMed
DOI: https://doi.org/10.1113/jphysiol.1975.sp011000; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC1309555/; PubMed
The journal: https://conductscience.org/library/journal-index/0266262; PubMed
Citations, by iCite: 118; iCite
Relative citation ratio, by iCite: 4.71; iCite
Revised in PubMed: 2019-05-09; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Roos A	A

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Lactates	Major topic
Muscles	Major topic
Animals
Cell Membrane
Cell Membrane Permeability
Diaphragm
Dimethadione
Hydrogen-Ion Concentration
In Vitro Techniques
Intracellular Fluid
Kinetics
Male
Membrane Potentials
Ouabain
Rats

Source PubMed

Show 9 more topicsShow fewer topics

References20

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,253,930	Intracellular pH and buffering power of rat muscle.	Am J Physiol	1971	https://conductscience.org/library/papers/4253930	PubMed
2	4,542,368	Anion conductance of frog muscle membranes: one channel, two kinds of pH dependence.	J Gen Physiol	1973	https://conductscience.org/library/papers/4542368	PubMed
3	5,022,689	Determination of intracellular buffering properties in rat diaphragm muscle.	Am J Physiol	1972	https://conductscience.org/library/papers/5022689	PubMed
4	4,957,065	Effects of 5,5-dimethyl-2,4-oxazolidinedione (DMO) on acid-base and electrolyte equilibria.	J Pharmacol Exp Ther	1966	https://conductscience.org/library/papers/4957065	PubMed
5	5,568,461	The buffer value of rat diaphragm muscle tissue determined by P CO2 equilibration of homogenates.	Respir Physiol	1971	https://conductscience.org/library/papers/5568461	PubMed
6	5,538,778	Carbohydrate metabolism and electrolyte changes in human muscle tissue during heavy work.	J Appl Physiol	1971	https://conductscience.org/library/papers/5538778	PubMed
7	5,359,443	Assay, purification and properties of mammalian D-2-hydroxy acid dehydrogenase.	Biochem J	1969	https://conductscience.org/library/papers/5359443	PubMed
8	5,776,240	Estimation of membrane potential and pH difference across the cristae membrane of rat liver mitochondria.	Eur J Biochem	1969	https://conductscience.org/library/papers/5776240	PubMed
9	5,648,435	Determination of intramitochondrial pH and intramitochondrial-extramitochondrial pH gradient of isolated heart mitochondria by the use of 5,5-dimethyl-2,4-oxazolidinedione. I. Changes during respiration and adenosine triphosphate-dependent transport of Ca++, Mg++, and Zn++.	J Biol Chem	1968	https://conductscience.org/library/papers/5648435	PubMed
10	5,641,607	Some mitochondrial changes in denervated muscle.	J Cell Sci	1968	https://conductscience.org/library/papers/5641607	PubMed
11	5,856,997	Active transport of 5,5-dimethyl-2,4-oxazolidinedione.	Science	1965	https://conductscience.org/library/papers/5856997	PubMed
12	5,846,926	Intracellular pH and intracellular buffering power of the cat brain.	Am J Physiol	1965	https://conductscience.org/library/papers/5846926	PubMed
16	14,402,240	The influence of potassium and chloride ions on the membrane potential of single muscle fibres.	J Physiol	1959	https://conductscience.org/library/papers/14402240	PubMed
17	14,060,441	THE INFLUENCE OF SODIUM-FREE SOLUTIONS ON THE MEMBRANE POTENTIAL OF FROG MUSCLE FIBERS.	J Gen Physiol	1963	https://conductscience.org/library/papers/14060441	PubMed
18	13,922,962	The oxidation of D-alpha-hydroxy acids in animal tissues.	Biochem J	1961	https://conductscience.org/library/papers/13922962	PubMed
19	13,654,506	Calculation of intracellular pH from the distribution of 5,5-dimethyl-2,4-oxazolidinedione (DMO); application to skeletal muscle of the dog.	J Clin Invest	1959	https://conductscience.org/library/papers/13654506	PubMed
24	13,215,068	The role of calcium ions in neural processes.	Pharmacol Rev	1954	https://conductscience.org/library/papers/13215068	PubMed
27	4,536,964	Intracellular pH, H ion flux and H ion permeability coefficient in bullfrog toe muscle.	J Physiol	1972	https://conductscience.org/library/papers/4536964	PubMed
28	5,039,276	Direct intracellular pH measurement in rat and crab muscle.	J Physiol	1972	https://conductscience.org/library/papers/5039276	PubMed
29	5,716,845	Sodium fluxes in diaphragm muscle and the effects of insulin and serum proteins.	J Physiol	1968	https://conductscience.org/library/papers/5716845	PubMed

Show 14 more referencesShow fewer references

Cited by35

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 118 citations.

PMID	Title	Journal	Year	In Papers	Source
34,937,963	Bicarbonate supplementation via lactate efflux improves anaerobic and cognitive performance in elite combat sport athletes.	Biol Sport	2021	https://conductscience.org/library/papers/34937963	PubMed
30,388,775	Chronic Ingestion of Sodium and Potassium Bicarbonate, with Potassium, Magnesium and Calcium Citrate Improves Anaerobic Performance in Elite Soccer Players.	Nutrients	2018	https://conductscience.org/library/papers/30388775	PubMed
29,322,250	Lactate metabolism: historical context, prior misinterpretations, and current understanding.	Eur J Appl Physiol	2018	https://conductscience.org/library/papers/29322250	PubMed
25,617,697	Mathematical modeling of acid-base physiology.	Prog Biophys Mol Biol	2015	https://conductscience.org/library/papers/25617697	PubMed
25,355,190	Muscle energetics during explosive activities and potential effects of nutrition and training.	Sports Med	2014	https://conductscience.org/library/papers/25355190	PubMed
24,965,589	Evidence from mathematical modeling that carbonic anhydrase II and IV enhance CO2 fluxes across Xenopus oocyte plasma membranes.	Am J Physiol Cell Physiol	2014	https://conductscience.org/library/papers/24965589	PubMed
20,851,859	Sharpey-Schafer lecture: gas channels.	Exp Physiol	2010	https://conductscience.org/library/papers/20851859	PubMed
19,879,980	Evaluating the role of carbonic anhydrases in the transport of HCO3--related species.	Biochim Biophys Acta	2010	https://conductscience.org/library/papers/19879980	PubMed
18,716,793	Cultured ruminal epithelial cells express a large-conductance channel permeable to chloride, bicarbonate, and acetate.	Pflugers Arch	2009	https://conductscience.org/library/papers/18716793	PubMed
11,251,055	Extracellular carbonic anhydrase activity facilitates lactic acid transport in rat skeletal muscle fibres.	J Physiol	2001	https://conductscience.org/library/papers/11251055	PubMed
9,365,920	Dissociation between lactate and proton exchange in muscle during intense exercise in man.	J Physiol	1997	https://conductscience.org/library/papers/9365920	PubMed
7,969,753	Effects of iron-induced lipid peroxidation and of acidosis on choline uptake by synaptosomes.	Neurochem Res	1994	https://conductscience.org/library/papers/7969753	PubMed
7,853,236	Lactate efflux from fatigued fast-twitch muscle fibres of Xenopus laevis under various extracellular conditions.	J Physiol	1994	https://conductscience.org/library/papers/7853236	PubMed
7,477,680	Acidosis-induced modifications of high-affinity choline uptake by synaptosomes: effects of pH readjustment.	Neurochem Res	1995	https://conductscience.org/library/papers/7477680	PubMed
7,265,004	The effects of chloride substitution on intracellular pH in crab muscle.	J Physiol	1981	https://conductscience.org/library/papers/7265004	PubMed
7,195,903	Intracellular pH of sea urchin eggs measured by the dimethyloxazolidinedione (DMO) method.	J Cell Biol	1981	https://conductscience.org/library/papers/7195903	PubMed
6,799,011	Cellular uptake of L-lactate in mouse diaphragm.	Biophys J	1981	https://conductscience.org/library/papers/6799011	PubMed
6,785,719	pH aspects of transient changes in conduction velocity in isolated heart fibers after partial replacement of chloride with organic anions.	Pflugers Arch	1981	https://conductscience.org/library/papers/6785719	PubMed
6,737,287	Effects of medium acetate on cellular volume in rabbit renal cortical slices.	J Physiol	1984	https://conductscience.org/library/papers/6737287	PubMed
6,707,968	The influence of muscle respiration and glycolysis on surface and intracellular pH in fibres of the rat soleus.	J Physiol	1984	https://conductscience.org/library/papers/6707968	PubMed

Show 14 more cited byShow fewer cited bySee all 35 cited by

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

Grants
Trials
Comments and corrections
Genes
Drugs
Data

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/239228

GET https://conductscience.org/api/papers/v1/239228/cited_by?page=2

API reference For AI assistants