Paper · 2413367

GTP-binding proteins couple cardiac muscarinic receptors to a K channel.

Pfaffinger PJ and 4 others. Nature, 1985. Cited by 826 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. GTP-binding proteins couple cardiac muscarinic receptors to a K channel. Papers, record 2413367. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2413367

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: GTP-binding proteins couple cardiac muscarinic receptors to a K channel.; PubMed
Journal: Nature; PubMed
Year: 1985; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/2413367/; PubMed
DOI: https://doi.org/10.1038/317536a0; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 826; iCite
Relative citation ratio, by iCite: 23.2; iCite
Revised in PubMed: 2019-06-17; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Pfaffinger PJ	P J
2	Martin JM	J M
3	Hunter DD	D D
4	Nathanson NM	N M
5	Hille B	B

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
GTP-Binding Proteins	Major topic
Ion Channels	Major topic
Potassium	Major topic
Receptors, Muscarinic	Major topic
Acetylcholine
Animals
Chick Embryo
Electrophysiology
Guanosine Triphosphate
Pertussis Toxin
Virulence Factors, Bordetella

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
GM07270	NIGMS NIH HHS	United States	T32GM007270	PubMed and NIH	NIH RePORTER
HL30639	NHLBI NIH HHS	United States	R01HL030639	PubMed and NIH	NIH RePORTER
NS08174	NINDS NIH HHS	United States	R01NS008174	PubMed and NIH	NIH RePORTER
			R37NS008174	NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by243

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 826 citations.

PMID	Title	Journal	Year	In Papers	Source
42,926,783	Stoichiometry-dependent gating and structural pharmacology of cardiac GIRK1/4 channels.	bioRxiv	2026	https://conductscience.org/library/papers/42926783	PubMed
42,306,299	G protein-coupled receptor signaling in osteogenic bone mesenchymal stem/stromal cells.	Front Cell Dev Biol	2026	https://conductscience.org/library/papers/42306299	PubMed
41,942,802	Efferent Inhibition of Hair Cells: Past, Present and Future.	J Assoc Res Otolaryngol	2026	https://conductscience.org/library/papers/41942802	PubMed
38,903,913	Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels.	Front Physiol	2024	https://conductscience.org/library/papers/38903913	PubMed
37,841,571	Signaling by Ion Channels: Pathways, Dynamics and Channelopathies.	Mo Med	2023	https://conductscience.org/library/papers/37841571	PubMed
37,154,294	Potentiation of neuronal activity by tonic GluD1 current in brain slices.	EMBO Rep	2023	https://conductscience.org/library/papers/37154294	PubMed
36,428,533	Adenosine and Adenosine Receptors: Advances in Atrial Fibrillation.	Biomedicines	2022	https://conductscience.org/library/papers/36428533	PubMed
35,030,226	Differential voltage-dependent modulation of the ACh-gated K+ current by adenosine and acetylcholine.	PLoS One	2022	https://conductscience.org/library/papers/35030226	PubMed
34,345,939	Kir Channel Molecular Physiology, Pharmacology, and Therapeutic Implications.	Handb Exp Pharmacol	2021	https://conductscience.org/library/papers/34345939	PubMed
33,383,710	P2 Receptors in Cardiac Myocyte Pathophysiology and Mechanotransduction.	Int J Mol Sci	2020	https://conductscience.org/library/papers/33383710	PubMed

1 to 10 of 243

See all 243 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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