Paper · 2425365

Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins.

Moczydlowski E and 3 others. Proc Natl Acad Sci U S A, 1986. Cited by 152 papers, by iCite.

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ConductScience Library. Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins. Papers, record 2425365. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2425365

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1986; PubMed
Publication types: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/2425365/; PubMed
DOI: https://doi.org/10.1073/pnas.83.14.5321; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC323943/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 152; iCite
Relative citation ratio, by iCite: 4.52; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Moczydlowski E	E
2	Olivera BM	B M
3	Gray WR	W R
4	Strichartz GR	G R

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Conotoxins	Major topic
Ion Channels	Major topic
Mollusk Venoms	Major topic
Muscles	Major topic
Neurons	Major topic
Saxitoxin	Major topic
Animals
Binding Sites
Binding, Competitive
Brain
Electric Organ
Electrophorus
Kinetics
Microsomes
Myocardium
Nephropidae
Rats

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
AM-35128	NIADDK NIH HHS	United States	R01AM035128	PubMed and NIH	NIH RePORTER
GM-22737	NIGMS NIH HHS	United States	R01GM022737	PubMed and NIH	NIH RePORTER
NS-12828	NINDS NIH HHS	United States	R01NS012828	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References33

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	6,305,931	Na+ channels with high and low affinity tetrodotoxin binding sites in the mammalian skeletal muscle cell. Difference in functional properties and sequential appearance during rat skeletal myogenesis.	J Biol Chem	1983	https://conductscience.org/library/papers/6305931	PubMed
2	6,852,238	The amino acid sequences of homologous hydroxyproline-containing myotoxins from the marine snail Conus geographus venom.	FEBS Lett	1983	https://conductscience.org/library/papers/6852238	PubMed
3	6,306,551	Differences in the properties of Na+ channels in muscle surface and T-tubular membranes revealed by tetrodotoxin derivatives.	Pflugers Arch	1983	https://conductscience.org/library/papers/6306551	PubMed
4	6,307,371	Saxitoxin and ouabain binding activity of isolated skeletal muscle membrane as indicators of surface origin and purity.	Biochim Biophys Acta	1983	https://conductscience.org/library/papers/6307371	PubMed
5	6,319,405	The sodium channel from rat brain. Purification and subunit composition.	J Biol Chem	1984	https://conductscience.org/library/papers/6319405	PubMed
6	6,086,336	Characterization, solubilization, affinity labeling and purification of the cardiac Na+ channel using Tityus toxin gamma.	Eur J Biochem	1984	https://conductscience.org/library/papers/6086336	PubMed
7	6,089,214	Single-channel properties of the reconstituted voltage-regulated Na channel isolated from the electroplax of Electrophorus electricus.	Proc Natl Acad Sci U S A	1984	https://conductscience.org/library/papers/6089214	PubMed
8	6,092,517	Structural determinants of the affinity of saxitoxin for neuronal sodium channels. Electrophysiological studies on frog peripheral nerve.	J Gen Physiol	1984	https://conductscience.org/library/papers/6092517	PubMed
9	6,096,479	Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins.	J Gen Physiol	1984	https://conductscience.org/library/papers/6096479	PubMed
10	2,579,711	Two subtypes of sodium channel with tetrodotoxin sensitivity and insensitivity detected in denervated mammalian skeletal muscle.	Brain Res	1985	https://conductscience.org/library/papers/2579711	PubMed

1 to 10 of 33

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Cited by48

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 152 citations.

PMID	Title	Journal	Year	In Papers	Source
40,710,502	Saxitoxin: A Comprehensive Review of Its History, Structure, Toxicology, Biosynthesis, Detection, and Preventive Implications.	Mar Drugs	2025	https://conductscience.org/library/papers/40710502	PubMed
39,684,313	Marine Peptides: Potential Basic Structures for the Development of Hybrid Compounds as Multitarget Therapeutics for the Treatment of Multifactorial Diseases.	Int J Mol Sci	2024	https://conductscience.org/library/papers/39684313	PubMed
37,103,349	Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels.	Mar Drugs	2023	https://conductscience.org/library/papers/37103349	PubMed
30,360,356	NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced NaV Channel Potency.	Molecules	2018	https://conductscience.org/library/papers/30360356	PubMed
26,690,478	Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition.	Toxins (Basel)	2015	https://conductscience.org/library/papers/26690478	PubMed
25,406,007	Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity.	Future Med Chem	2014	https://conductscience.org/library/papers/25406007	PubMed
23,008,436	Use-dependent block of the voltage-gated Na(+) channel by tetrodotoxin and saxitoxin: effect of pore mutations that change ionic selectivity.	J Gen Physiol	2012	https://conductscience.org/library/papers/23008436	PubMed
22,308,389	Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.	Proc Natl Acad Sci U S A	2012	https://conductscience.org/library/papers/22308389	PubMed
21,652,775	μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve.	Proc Natl Acad Sci U S A	2011	https://conductscience.org/library/papers/21652775	PubMed
20,714,429	The tetrodotoxin receptor of voltage-gated sodium channels--perspectives from interactions with micro-conotoxins.	Mar Drugs	2010	https://conductscience.org/library/papers/20714429	PubMed

1 to 10 of 48

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None in this release.

Drugs0

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None in this release.

Data0

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None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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