Paper · 24256732
Drug discovery: Pocket of opportunity.
Bollag G and 1 other. Nature, 2013. Cited by 13 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
Cite this record
ConductScience Library. Drug discovery: Pocket of opportunity. Papers, record 24256732. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/24256732
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
Topics6
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Allosteric Site | Major topic |
| Guanosine Diphosphate | Major topic |
| Guanosine Triphosphate | Major topic |
| Mutant Proteins | Major topic |
| Oncogene Protein p21(ras) | Major topic |
| Humans |
Source PubMed
Grants0
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
None in this release.
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections1
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
| Kind | PMID | Title | In Papers |
|---|---|---|---|
| Comment on | 24,256,730 | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. | https://conductscience.org/library/papers/24256730 |
Source PubMed
References10
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 22,004,085 | Inhibition of Ras for cancer treatment: the search continues. | Future Med Chem | 2011 | https://conductscience.org/library/papers/22004085 | PubMed |
| 2 | 23,698,361 | Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. | Nature | 2013 | https://conductscience.org/library/papers/23698361 | PubMed |
| 3 | 22,431,598 | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. | Proc Natl Acad Sci U S A | 2012 | https://conductscience.org/library/papers/22431598 | PubMed |
| 4 | 23,782,158 | Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. | N Engl J Med | 2013 | https://conductscience.org/library/papers/23782158 | PubMed |
| 5 | 23,816,960 | Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. | J Clin Oncol | 2013 | https://conductscience.org/library/papers/23816960 | PubMed |
| 6 | 23,630,290 | In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. | Proc Natl Acad Sci U S A | 2013 | https://conductscience.org/library/papers/23630290 | PubMed |
| 7 | 22,566,140 | Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. | Angew Chem Int Ed Engl | 2012 | https://conductscience.org/library/papers/22566140 | PubMed |
| 8 | 24,256,730 | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. | Nature | 2013 | https://conductscience.org/library/papers/24256730 | PubMed |
| 9 | 16,769,983 | Lately, it occurs to me what a long, strange trip it's been for the farnesyltransferase inhibitors. | J Clin Oncol | 2006 | https://conductscience.org/library/papers/16769983 | PubMed |
| 10 | 23,921,727 | US National Cancer Institute's new Ras project targets an old foe. | Nat Med | 2013 | https://conductscience.org/library/papers/23921727 | PubMed |
Cited by8
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 13 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 35,546,148 | AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis. | Nat Commun | 2022 | https://conductscience.org/library/papers/35546148 | PubMed |
| 34,163,104 | Pancreatic adenocarcinoma: A review of recent paradigms and advances in epidemiology, clinical diagnosis and management. | World J Gastroenterol | 2021 | https://conductscience.org/library/papers/34163104 | PubMed |
| 32,869,838 | Inhibition of RAS: proven and potential vulnerabilities. | Biochem Soc Trans | 2020 | https://conductscience.org/library/papers/32869838 | PubMed |
| 30,618,127 | Preclinical pharmacodynamic evaluation of a new Src/FOSL1 inhibitor, LY-1816, in pancreatic ductal adenocarcinoma. | Cancer Sci | 2019 | https://conductscience.org/library/papers/30618127 | PubMed |
| 28,286,004 | Computational Modeling Reveals that Signaling Lipids Modulate the Orientation of K-Ras4A at the Membrane Reflecting Protein Topology. | Structure | 2017 | https://conductscience.org/library/papers/28286004 | PubMed |
| 28,220,783 | An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer. | Nat Commun | 2017 | https://conductscience.org/library/papers/28220783 | PubMed |
| 26,841,430 | Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism. | Science | 2016 | https://conductscience.org/library/papers/26841430 | PubMed |
| 25,977,330 | Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions. | Cancer Res | 2015 | https://conductscience.org/library/papers/25977330 | PubMed |
Genes0
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
None in this release.
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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