Paper · 2433293

Phasic release of newly synthesized secretory proteins in the unstimulated rat exocrine pancreas.

Arvan P and 1 other. J Cell Biol, 1987. Cited by 98 papers, by iCite.

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ConductScience Library. Phasic release of newly synthesized secretory proteins in the unstimulated rat exocrine pancreas. Papers, record 2433293. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2433293

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Phasic release of newly synthesized secretory proteins in the unstimulated rat exocrine pancreas.; PubMed
Journal: J Cell Biol; PubMed
Year: 1987; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/2433293/; PubMed
DOI: https://doi.org/10.1083/jcb.104.2.243; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2114415/; PubMed
The journal: https://conductscience.org/library/journal-index/0375356; PubMed
Citations, by iCite: 98; iCite
Relative citation ratio, by iCite: 2.15; iCite
Revised in PubMed: 2025-06-05; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Arvan P	P
2	Castle JD	J D

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Amylases	Major topic
Chymotrypsinogen	Major topic
Enzyme Precursors	Major topic
Lipase	Major topic
Pancreas	Major topic
Pancreatic Hormones	Major topic
Trypsinogen	Major topic
Animals
Cytoplasmic Granules
Endoplasmic Reticulum
Exocytosis
Golgi Apparatus
In Vitro Techniques
Kinetics
Male
Molecular Weight
Rats
Rats, Inbred Strains

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
GM-26324	NIGMS NIH HHS	United States	R01GM026324	PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References34

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	6,035,648	Intracellular transport of secretory proteins in the pancreatic exocrine cell. II. Transport to condensing vacuoles and zymogen granules.	J Cell Biol	1967	https://conductscience.org/library/papers/6035648	PubMed
2	3,012,361	Re-routing of a secretory protein by fusion with human growth hormone sequences.	Nature	1986	https://conductscience.org/library/papers/3012361	PubMed
3	5,432,063	Cleavage of structural proteins during the assembly of the head of bacteriophage T4.	Nature	1970	https://conductscience.org/library/papers/5432063	PubMed
4	5,085,985	Fluorescamine: a reagent for assay of amino acids, peptides, proteins, and primary amines in the picomole range.	Science	1972	https://conductscience.org/library/papers/5085985	PubMed
5	4,824,860	Secretion of digestive enzyme derived from two parallel intracellular pools.	Am J Physiol	1974	https://conductscience.org/library/papers/4824860	PubMed
6	1,123,325	Studies on the guinea pig pancreas. Parallel discharge of exocrine enzyme activities.	J Biol Chem	1975	https://conductscience.org/library/papers/1123325	PubMed
7	1,096,303	Intracellular aspects of the process of protein synthesis.	Science	1975	https://conductscience.org/library/papers/1096303	PubMed
8	954,054	Studies on intracellular transport of secretory proteins in the rat exocrine pancreas. V. Kinetic studies on accelerated transport following caerulein infusion in vivo.	Cell Tissue Res	1976	https://conductscience.org/library/papers/954054	PubMed
9	10,308	Secretion of old versus new exportable protein in rat parotid slics. Control by neurotransmitters.	J Cell Biol	1976	https://conductscience.org/library/papers/10308	PubMed
10	832,790	Discharge of newly synthesized proteins in pure juice collected from the human pancreas. Indication of more than one pool of intracellular digestive enzymes.	Gastroenterology	1977	https://conductscience.org/library/papers/832790	PubMed

1 to 10 of 34

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Cited by27

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 98 citations.

PMID	Title	Journal	Year	In Papers	Source
26,618,189	Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells.	Cell Mol Gastroenterol Hepatol	2015	https://conductscience.org/library/papers/26618189	PubMed
24,742,357	Ca²⁺-regulated secretory granule exocytosis in pancreatic and parotid acinar cells.	Cell Calcium	2014	https://conductscience.org/library/papers/24742357	PubMed
23,868,405	Tumor protein D52 controls trafficking of an apical endolysosomal secretory pathway in pancreatic acinar cells.	Am J Physiol Gastrointest Liver Physiol	2013	https://conductscience.org/library/papers/23868405	PubMed
21,586,796	A novel conserved targeting motif found in ABCA transporters mediates trafficking to early post-Golgi compartments.	J Lipid Res	2011	https://conductscience.org/library/papers/21586796	PubMed
11,733,555	Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis to the basal membrane.	J Clin Invest	2001	https://conductscience.org/library/papers/11733555	PubMed
11,007,891	Biogenesis of regulated exocytotic carriers in neuroendocrine cells.	J Neurosci	2000	https://conductscience.org/library/papers/11007891	PubMed
9,620,860	Sorting and storage during secretory granule biogenesis: looking backward and looking forward.	Biochem J	1998	https://conductscience.org/library/papers/9620860	PubMed
9,548,715	Mannose 6-phosphate receptors are sorted from immature secretory granules via adaptor protein AP-1, clathrin, and syntaxin 6-positive vesicles.	J Cell Biol	1998	https://conductscience.org/library/papers/9548715	PubMed
9,151,667	Differential sorting of lysosomal enzymes out of the regulated secretory pathway in pancreatic beta-cells.	J Cell Biol	1997	https://conductscience.org/library/papers/9151667	PubMed
9,029,145	Micromolar and submicromolar Ca2+ spikes regulating distinct cellular functions in pancreatic acinar cells.	EMBO J	1997	https://conductscience.org/library/papers/9029145	PubMed

1 to 10 of 27

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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