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Paper · 2449865

Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms.

Retsema J and 8 others. Antimicrob Agents Chemother, 1987. Cited by 403 papers, by iCite.

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ConductScience Library. Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms. Papers, record 2449865. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2449865

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms.
PubMed
Journal
Antimicrob Agents Chemother
PubMed
Year
1987
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
403
iCite
Relative citation ratio, by iCite
15.3
iCite
Revised in PubMed
2021-05-26
PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Retsema JJ
2Girard AA
3Schelkly WW
4Manousos MM
5Anderson MM
6Bright GG
7Borovoy RR
8Brennan LL
9Mason RR

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Anti-Bacterial AgentsMajor topic
ErythromycinMajor topic
Gram-Negative BacteriaMajor topic
Azithromycin
Bacterial Proteins
Enterobacteriaceae
Escherichia coli
Microbial Sensitivity Tests
RNA, Bacterial
RNA, Messenger
Ribosomes
Staphylococcus aureus

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References13

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
13,536,500Antimicrobial chemotherapy of chlamydial infection: where next?Eur J Clin Microbiol1986https://conductscience.org/library/papers/3536500PubMed
26,638,988In vitro evaluation of three new macrolide antimicrobial agents, RU28965, RU29065, and RU29702, and comparisons with other orally administered drugs.Antimicrob Agents Chemother1983https://conductscience.org/library/papers/6638988PubMed
34,996,450Binding of erythromycin to Escherichia coli ribosomes.J Antibiot (Tokyo)1971https://conductscience.org/library/papers/4996450PubMed
46,703,675Evaluation of three 4"-deoxy-4"-sulfonamido-oleandomycin derivatives with erythromycin-like antibacterial potency.Antimicrob Agents Chemother1984https://conductscience.org/library/papers/6703675PubMed
53,488,019In vitro activity of the new macrolide antibiotic roxithromycin (RU 28965) against clinical isolates of Haemophilus influenzae.Antimicrob Agents Chemother1986https://conductscience.org/library/papers/3488019PubMed
62,830,841Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution.Antimicrob Agents Chemother1987https://conductscience.org/library/papers/2830841PubMed
73,767,346Susceptibility of Campylobacter pyloridis to three macrolide antibiotics (erythromycin, roxithromycin [RU 28965], and CP 62,993) and rifampin.Antimicrob Agents Chemother1986https://conductscience.org/library/papers/3767346PubMed
83,038,010In vitro evaluation of CP-62,993, erythromycin, clindamycin, and tetracycline against Chlamydia trachomatis.Antimicrob Agents Chemother1987https://conductscience.org/library/papers/3038010PubMed
92,949,695In vitro and in vivo evaluation of A-56268 (TE-031), a new macrolide.Antimicrob Agents Chemother1986https://conductscience.org/library/papers/2949695PubMed
104,599,122Antibiotics as probes of ribosome structure: binding of chloramphenicol and erythromycin to polyribosomes; effect of other antibiotics.Antimicrob Agents Chemother1974https://conductscience.org/library/papers/4599122PubMed

1 to 10 of 13

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Cited by139

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 403 citations.

PMIDTitleJournalYearIn PapersSource
42,769,955The hidden cost of antibiotics: microbial dysbiosis-induced SCFA imbalance and its underlying mechanisms.Front Immunol2026https://conductscience.org/library/papers/42769955PubMed
41,874,376Benzoxaborole-modified azithromycins inhibit translation without inducing ermC expression.Antimicrob Agents Chemother2026https://conductscience.org/library/papers/41874376PubMed
41,845,216The effect of biochanin A on the antibiotic susceptibilities of Escherichia coli grown under different respiration and metabolic conditions on agar media.BMC Microbiol2026https://conductscience.org/library/papers/41845216PubMed
40,927,449Antimicrobial susceptibility profiles of thermophilic Campylobacter species from human, pig, and chicken feces in Rwanda.Front Microbiol2025https://conductscience.org/library/papers/40927449PubMed
40,668,040Evaluating Effects of Antibiotics Across Preclinical Models of the Human Gastrointestinal Microbiota.Microbiologyopen2025https://conductscience.org/library/papers/40668040PubMed
40,524,025The Next Frontier: Unveiling Novel Approaches for Combating Multidrug-Resistant Bacteria.Pharm Res2025https://conductscience.org/library/papers/40524025PubMed
40,076,911The Non-Antibacterial Effects of Azithromycin and Other Macrolides on the Bronchial Epithelial Barrier and Cellular Differentiation.Int J Mol Sci2025https://conductscience.org/library/papers/40076911PubMed
39,119,898Plasmid-mediated azithromycin resistance in non-typhoidal Salmonella recovered from human infections.J Antimicrob Chemother2024https://conductscience.org/library/papers/39119898PubMed
39,002,075Efficacy and safety of topical azithromycin therapy in patients with blepharitis and meibomian gland dysfunction.Jpn J Ophthalmol2024https://conductscience.org/library/papers/39002075PubMed
38,411,248Macrolide antibiotics (including azithromycin) for cystic fibrosis.Cochrane Database Syst Rev2024https://conductscience.org/library/papers/38411248PubMed

1 to 10 of 139

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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