Paper · 25359882

Blocking Hedgehog release from pancreatic cancer cells increases paracrine signaling potency.

Damhofer H and 5 others. J Cell Sci, 2015. Cited by 21 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Blocking Hedgehog release from pancreatic cancer cells increases paracrine signaling potency. Papers, record 25359882. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/25359882

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Blocking Hedgehog release from pancreatic cancer cells increases paracrine signaling potency.; PubMed
Journal: J Cell Sci; PubMed
Year: 2015; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/25359882/; PubMed
DOI: https://doi.org/10.1242/jcs.157966; PubMed
The journal: https://conductscience.org/library/journal-index/0052457; PubMed
Citations, by iCite: 21; iCite
Relative citation ratio, by iCite: 0.54; iCite
Revised in PubMed: 2018-12-02; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Damhofer H	Helene
2	Veenstra VL	Veronique L
3	Tol JA	Johanna A M G
4	van Laarhoven HW	Hanneke W M
5	Medema JP	Jan Paul
6	Bijlsma MF	Maarten F

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Hedgehog Proteins	Major topic
Neoplasm Proteins	Major topic
Pancreatic Neoplasms	Major topic
Paracrine Communication	Major topic
Signal Transduction	Major topic
ADAM Proteins
Animals
Cell Line, Tumor
HEK293 Cells
Humans
Mice

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by17

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 21 citations.

PMID	Title	Journal	Year	In Papers	Source
41,507,312	Scube2 primes Dispatched and ADAM10-mediated Shh release by recruiting HDL acceptors to the plasma membrane.	Commun Biol	2026	https://conductscience.org/library/papers/41507312	PubMed
40,508,010	Stromal Hedgehog Signaling Is Associated with Favorable Outcomes in Pancreatic Cancer.	Int J Mol Sci	2025	https://conductscience.org/library/papers/40508010	PubMed
39,297,609	Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins.	Elife	2024	https://conductscience.org/library/papers/39297609	PubMed
34,235,374	Cholesterol and CDON Regulate Sonic Hedgehog Release from Pancreatic Cancer Cells.	J Pancreat Cancer	2021	https://conductscience.org/library/papers/34235374	PubMed
33,732,377	Nuclear factor-κB inhibitor Bay11-7082 inhibits gastric cancer cell proliferation by inhibiting Gli1 expression.	Oncol Lett	2021	https://conductscience.org/library/papers/33732377	PubMed
33,090,184	Range of SHH signaling in adrenal gland is limited by membrane contact to cells with primary cilia.	J Cell Biol	2020	https://conductscience.org/library/papers/33090184	PubMed
32,637,415	ADAM9 Mediates Triple-Negative Breast Cancer Progression via AKT/NF-κB Pathway.	Front Med (Lausanne)	2020	https://conductscience.org/library/papers/32637415	PubMed
31,018,591	Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding.	Molecules	2019	https://conductscience.org/library/papers/31018591	PubMed
30,977,233	Loss of the Heparan Sulfate Proteoglycan Glypican5 Facilitates Long-Range Sonic Hedgehog Signaling.	Stem Cells	2019	https://conductscience.org/library/papers/30977233	PubMed
30,442,938	ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy.	Oncogenesis	2018	https://conductscience.org/library/papers/30442938	PubMed

1 to 10 of 17

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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