Paper · 25384

Antacid titration in the prevention of acute gastrointestinal bleeding: a controlled, randomized trial in 100 critically ill patients.

Hastings PR and 3 others. N Engl J Med, 1978. Cited by 420 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Antacid titration in the prevention of acute gastrointestinal bleeding: a controlled, randomized trial in 100 critically ill patients. Papers, record 25384. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/25384

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Antacid titration in the prevention of acute gastrointestinal bleeding: a controlled, randomized trial in 100 critically ill patients.; PubMed
Journal: N Engl J Med; PubMed
Year: 1978; PubMed
Publication types: Clinical Trial, Journal Article, Randomized Controlled Trial; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/25384/; PubMed
DOI: https://doi.org/10.1056/nejm197805112981901; PubMed
The journal: https://conductscience.org/library/journal-index/0255562; PubMed
Citations, by iCite: 420; iCite
Relative citation ratio, by iCite: 18.3; iCite
Revised in PubMed: 2022-03-31; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Hastings PR	P R
2	Skillman JJ	J J
3	Bushnell LS	L S
4	Silen W	W

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Antacids	Major topic
Critical Care	Major topic
Gastrointestinal Hemorrhage	Major topic
Acute Disease
Aged
Female
Gastric Acidity Determination
Humans
Hydrogen-Ion Concentration
Middle Aged
Postoperative Complications
Risk
Statistics as Topic

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by69

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 420 citations.

PMID	Title	Journal	Year	In Papers	Source
40,087,807	The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024.	J Intensive Care	2025	https://conductscience.org/library/papers/40087807	PubMed
39,996,161	The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024.	Acute Med Surg	2025	https://conductscience.org/library/papers/39996161	PubMed
38,997,152	Pharmacological interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units: a network meta-analysis.	BMJ Evid Based Med	2025	https://conductscience.org/library/papers/38997152	PubMed
34,518,899	Current practice of stress ulcer prophylaxis in a surgical patient cohort in a German university hospital.	Langenbecks Arch Surg	2021	https://conductscience.org/library/papers/34518899	PubMed
34,484,801	The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020).	Acute Med Surg	2021	https://conductscience.org/library/papers/34484801	PubMed
34,433,491	The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020).	J Intensive Care	2021	https://conductscience.org/library/papers/34433491	PubMed
33,354,031	The Seventh Organ-Gastrointestinal Tract: Neglect at Your Own Peril!	Indian J Crit Care Med	2020	https://conductscience.org/library/papers/33354031	PubMed
32,399,377	Trends and Outcomes of Gastrointestinal Bleeding Among Septic Shock Patients of the United States: A 10-Year Analysis of a Nationwide Inpatient Sample.	Cureus	2020	https://conductscience.org/library/papers/32399377	PubMed
32,214,442	The SUP-ICU Trial: Does It Confirm or Condemn the Practice of Stress Ulcer Prophylaxis?	Hosp Pharm	2020	https://conductscience.org/library/papers/32214442	PubMed
31,057,751	Fluorescence lifetime imaging of upper gastrointestinal pH in vivo with a lanthanide based near-infrared τ probe.	Chem Sci	2019	https://conductscience.org/library/papers/31057751	PubMed

1 to 10 of 69

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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