Paper26747
How should values of pA2 and affinity constants for pharmacological competitive antagonists be estimated?
MacKay D. J Pharm Pharmacol, 1978. Cited by 281 papers, by iCite.
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ConductScience Library. How should values of pA2 and affinity constants for pharmacological competitive antagonists be estimated? Papers, record 26747. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/26747
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- How should values of pA2 and affinity constants for pharmacological competitive antagonists be estimated?
- PubMed
Topics6
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Drug Antagonism | Major topic |
| Pharmaceutical Preparations | Major topic |
| Receptors, Drug | Major topic |
| Binding, Competitive | |
| Mathematics | |
| Models, Biological |
Source PubMed
Cited by69
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 281 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 26,047,780 | Beta adrenergic modulation of spontaneous microcontractions and electrical field-stimulated contractions in isolated strips of rat urinary bladder from normal animals and animals with partial bladder outflow obstruction. | Naunyn Schmiedebergs Arch Pharmacol | 2015 | https://conductscience.org/library/papers/26047780 | PubMed |
| 25,210,400 | Antidepressant-like effect of a novel 5-HT3 receptor antagonist N-(benzo[d] thiazol-2-yl)-3-ethoxyquinoxalin-2-carboxamide 6k using rodents behavioral battery tests. | J Pharmacol Pharmacother | 2014 | https://conductscience.org/library/papers/25210400 | PubMed |
| 24,197,641 | Electromechanical effects of acetylcholine on the atrial tissues of the cultured tilapia (Oreochromis nilotica × O. aureus). | Fish Physiol Biochem | 1995 | https://conductscience.org/library/papers/24197641 | PubMed |
| 24,014,909 | Antidepressant-like effect of novel 5-HT3 receptor antagonist N-n-butyl-3-ethoxyquinoxalin-2-carboxamide (6p): an approach using rodent behavioral antidepressant tests. | Indian J Pharmacol | 2013 | https://conductscience.org/library/papers/24014909 | PubMed |
| 23,493,308 | Antidepressant Potential of 5-HT3 Receptor Antagonist, N-n- propyl-3-ethoxyquinoxaline-2-carboxamide (6n). | J Young Pharm | 2012 | https://conductscience.org/library/papers/23493308 | PubMed |
| 15,477,223 | Noncompetitive antagonism of BIBN4096BS on CGRP-induced responses in human subcutaneous arteries. | Br J Pharmacol | 2004 | https://conductscience.org/library/papers/15477223 | PubMed |
| 11,877,320 | 5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro. | Br J Pharmacol | 2002 | https://conductscience.org/library/papers/11877320 | PubMed |
| 11,487,525 | An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea. | Br J Pharmacol | 2001 | https://conductscience.org/library/papers/11487525 | PubMed |
| 11,053,211 | Beta-agonist-induced constitutive beta(2)-adrenergic receptor activity in bovine tracheal smooth muscle. | Br J Pharmacol | 2000 | https://conductscience.org/library/papers/11053211 | PubMed |
| 10,455,318 | Analysis of the atypical characteristics of adenosine receptors mediating negative inotropic and chronotropic responses of guinea-pig isolated atria and papillary muscles. | Br J Pharmacol | 1999 | https://conductscience.org/library/papers/10455318 | PubMed |
| 8,968,543 | Influence of adrenodemedullation on beta 2- and beta 3-adrenoceptors mediating relaxation of oesophageal smooth muscle of spontaneously hypertensive rats. | Br J Pharmacol | 1996 | https://conductscience.org/library/papers/8968543 | PubMed |
| 8,894,179 | Characteristics of cyanopindolol analogues active at the beta 3-adrenoceptor in rat ileum. | Br J Pharmacol | 1996 | https://conductscience.org/library/papers/8894179 | PubMed |
| 8,878,056 | Pharmacokinetic and alpha 1-adrenoceptor antagonistic properties of two cyanine-type inhibitors of extraneuronal monoamine transport. | Naunyn Schmiedebergs Arch Pharmacol | 1996 | https://conductscience.org/library/papers/8878056 | PubMed |
| 8,821,531 | Functional identification of rat atypical beta-adrenoceptors by the first beta 3-selective antagonists, aryloxypropanolaminotetralins. | Br J Pharmacol | 1996 | https://conductscience.org/library/papers/8821531 | PubMed |
| 8,719,791 | Inhibition of bradykinin-evoked trigeminal nerve stimulation by the non-peptide bradykinin B2 receptor antagonist WIN 64338 in vivo and in vitro. | Br J Pharmacol | 1995 | https://conductscience.org/library/papers/8719791 | PubMed |
| 8,646,418 | Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol. | Br J Pharmacol | 1996 | https://conductscience.org/library/papers/8646418 | PubMed |
| 8,495,246 | Functional characterization of muscarinic receptors in murine airways. | Br J Pharmacol | 1993 | https://conductscience.org/library/papers/8495246 | PubMed |
| 8,306,100 | Effects of selective antagonism of beta-adrenoceptor sub-types on responses to isoprenaline in rat distal colon in vitro. | Br J Pharmacol | 1993 | https://conductscience.org/library/papers/8306100 | PubMed |
| 8,106,109 | The beta-adrenoceptors mediating relaxation of rat oesophageal muscularis mucosae are predominantly of the beta 3-, but also of the beta 2-subtype. | Br J Pharmacol | 1993 | https://conductscience.org/library/papers/8106109 | PubMed |
| 8,032,617 | Pharmacological characterization and anatomical localization of prejunctional beta-adrenoceptors in the rat kidney. | Br J Pharmacol | 1994 | https://conductscience.org/library/papers/8032617 | PubMed |
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- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
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- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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