Paper · 26915

Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine.

Field M and 3 others. Proc Natl Acad Sci U S A, 1978. Cited by 600 papers, by iCite.

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ConductScience Library. Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine. Papers, record 26915. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/26915

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1978; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/26915/; PubMed
DOI: https://doi.org/10.1073/pnas.75.6.2800; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC392652/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 600; iCite
Relative citation ratio, by iCite: 17.8; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Field M	M
2	Graf LH Jr	L H
3	Laird WJ	W J
4	Smith PL	P L

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Bacterial Toxins	Major topic
Cyclic GMP	Major topic
Enterotoxins	Major topic
Guanylate Cyclase	Major topic
Intestine, Small	Major topic
Chlorides
Electric Conductivity
Escherichia coli
Intestinal Absorption
Intestinal Mucosa
Membrane Potentials

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References23

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	177,461	Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2'0 acetylation by acetic anhydride in aqueous solution.	J Cyclic Nucleotide Res	1975	https://conductscience.org/library/papers/177461	PubMed
2	9,403	Stimulation of guanylate cyclase of fibroblasts by free fatty acids.	J Biol Chem	1976	https://conductscience.org/library/papers/9403	PubMed
3	196,088	Ca ionophore-stimulated ion secretion in rabbit ileal mucosa: relation to actions of cyclic 3',5'-AMP and carbamylcholine.	J Membr Biol	1977	https://conductscience.org/library/papers/196088	PubMed
4	203,862	Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli.	Nature	1978	https://conductscience.org/library/papers/203862	PubMed
5	237,786	The localization of guanylate cyclase in rat small intestinal epithelium.	FEBS Lett	1975	https://conductscience.org/library/papers/237786	PubMed
6	238,408	Catecholamine effects on cyclic AMP levels and ion secretion in rabbit ileal mucosa.	Am J Physiol	1975	https://conductscience.org/library/papers/238408	PubMed
7	238,899	Adenylate and guanylate cyclase activities and cellular differentiation in rat small intestine.	Gastroenterology	1975	https://conductscience.org/library/papers/238899	PubMed
8	346,481	Purification and chemical characterization of the heat-stable enterotoxin produced by porcine strains of enterotoxigenic Escherichia coli.	Infect Immun	1978	https://conductscience.org/library/papers/346481	PubMed
9	4,131,518	Relationships among heat-labile enterotoxins of Escherichia coli and Vibrio cholerae.	J Infect Dis	1974	https://conductscience.org/library/papers/4131518	PubMed
10	4,311,196	Effects of some hormonal and other factors on the excretion of guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate in rat urine.	J Biol Chem	1969	https://conductscience.org/library/papers/4311196	PubMed

1 to 10 of 23

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Cited by205

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 600 citations.

PMID	Title	Journal	Year	In Papers	Source
39,145,455	The forgotten pandemic: how understanding cholera illuminated mechanisms of chloride channels in multiple diseases.	J Clin Invest	2024	https://conductscience.org/library/papers/39145455	PubMed
38,280,053	Breaking Down Barriers: Epithelial Contributors to Monogenic IBD Pathogenesis.	Inflamm Bowel Dis	2024	https://conductscience.org/library/papers/38280053	PubMed
37,630,557	Reduced Plasma Guanylin Levels Following Enterotoxigenic Escherichia coli-Induced Diarrhea.	Microorganisms	2023	https://conductscience.org/library/papers/37630557	PubMed
35,846,281	Receptor Guanylyl Cyclase C and Cyclic GMP in Health and Disease: Perspectives and Therapeutic Opportunities.	Front Endocrinol (Lausanne)	2022	https://conductscience.org/library/papers/35846281	PubMed
35,191,758	Enterotoxigenic Escherichia coli Enterotoxins Regulate Epithelial to Immune Relay of IL-33 and IL-1Ra Cytokines.	Infect Immun	2022	https://conductscience.org/library/papers/35191758	PubMed
35,052,900	Antimicrobial Resistance, Serologic and Molecular Characterization of E. coli Isolated from Calves with Severe or Fatal Enteritis in Bavaria, Germany.	Antibiotics (Basel)	2021	https://conductscience.org/library/papers/35052900	PubMed
34,244,980	Pig vaccination strategies based on enterotoxigenic Escherichia coli toxins.	Braz J Microbiol	2021	https://conductscience.org/library/papers/34244980	PubMed
34,056,991	Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential.	Expert Opin Ther Targets	2021	https://conductscience.org/library/papers/34056991	PubMed
33,949,097	Novel GUCY2C variant causing familial diarrhea in a Mennonite kindred and a potential therapeutic approach.	Am J Med Genet A	2021	https://conductscience.org/library/papers/33949097	PubMed
32,089,675	Abnormal Uroguanylin Immunoreactive Cells Density in the Duodenum of Patients with Diarrhea-Predominant Irritable Bowel Syndrome Changes following Fecal Microbiota Transplantation.	Gastroenterol Res Pract	2020	https://conductscience.org/library/papers/32089675	PubMed

1 to 10 of 205

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Genes0

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None in this release.

Drugs0

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None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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