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Paper · 29352183

Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus.

Zhang TY and 12 others. Nat Commun, 2018. Cited by 116 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus. Papers, record 29352183. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/29352183

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus.
PubMed
Journal
Nat Commun
PubMed
Year
2018
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
116
iCite
Relative citation ratio, by iCite
4.66
iCite
Revised in PubMed
2026-11-02
PubMed

Authors13

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Zhang TYTie-Yuanhttps://orcid.org/0000-0002-6368-2606
2Keown CLChristopher L
3Wen XXianglan
4Li JJunhao
5Vousden DADulcie A
6Anacker CChristoph
7Bhattacharyya UUrvashi
8Ryan RRichard
9Diorio JJosie
10O'Toole NNicholas

1 to 10 of 13Source PubMed

See all 13 authors

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Conditioning, PsychologicalMajor topic
Dentate GyrusMajor topic
Epigenesis, GeneticMajor topic
Gene-Environment InteractionMajor topic
Nerve Tissue ProteinsMajor topic
NeurogenesisMajor topic
TranscriptomeMajor topic
Animals
Animals, Newborn
Basic Helix-Loop-Helix Proteins
Binding Sites
DNA
DNA Methylation
Gene Expression Regulation, Developmental
Magnetic Resonance Imaging
Male
Mice
Mice, Inbred C57BL
Neuronal Plasticity
Neurons
Protein Binding

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
T32 MH020002NIMH NIH HHSUnited StatesT32MH020002PubMed and NIHNIH RePORTER
R00NS080911NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References58

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
121,829,155Multiple-mouse neuroanatomical magnetic resonance imaging.J Vis Exp2011https://conductscience.org/library/papers/21829155PubMed
223,828,890Global epigenomic reconfiguration during mammalian brain development.Science2013https://conductscience.org/library/papers/23828890PubMed
311,257,907Neural consequences of environmental enrichment.Nat Rev Neurosci2000https://conductscience.org/library/papers/11257907PubMed
425,126,069Pydpiper: a flexible toolkit for constructing novel registration pipelines.Front Neuroinform2014https://conductscience.org/library/papers/25126069PubMed
517,659,998Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain.Med Image Anal2008https://conductscience.org/library/papers/17659998PubMed
626,177,923Grhl2 is required in nonneural tissues for neural progenitor survival and forebrain development.Genesis2015https://conductscience.org/library/papers/26177923PubMed
717,942,324Automated deformation analysis in the YAC128 Huntington disease mouse model.Neuroimage2008https://conductscience.org/library/papers/17942324PubMed
826,430,216Transcription-Factor-Dependent Control of Adult Hippocampal Neurogenesis.Cold Spring Harb Perspect Biol2015https://conductscience.org/library/papers/26430216PubMed
920,474,079Impaired hippocampal neurogenesis and vascular formation in ephrin-A5-deficient mice.Stem Cells2010https://conductscience.org/library/papers/20474079PubMed
1019,958,180Epigenetics and the environmental regulation of the genome and its function.Annu Rev Psychol2010https://conductscience.org/library/papers/19958180PubMed

1 to 10 of 58

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Cited by73

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 116 citations.

PMIDTitleJournalYearIn PapersSource
42,786,261Multi-omics characterization of chronic social defeat stress recall-activated nuclei in Arc-GFP mice.Mol Psychiatry2026https://conductscience.org/library/papers/42786261PubMed
42,728,392The ventral hippocampus: computations, circuits and functions.Nat Rev Neurosci2026https://conductscience.org/library/papers/42728392PubMed
42,642,673Systematic Review and Transcriptomic Meta-analysis of Environmental Enrichment Reveal Core Molecular Programs of Brain Plasticity.Mol Neurobiol2026https://conductscience.org/library/papers/42642673PubMed
42,380,695Environmental enrichment modulates, but does not normalize, aging-associated immune transcriptional programs after ischemic stroke.Funct Integr Genomics2026https://conductscience.org/library/papers/42380695PubMed
41,901,029A Quantitative Comparison of Medial and Coronal Dentate Gyrus Microdissection Strategies and a Softening-Based Workflow for Reproducible Tissue Procurement.Life (Basel)2026https://conductscience.org/library/papers/41901029PubMed
41,659,563Spatial transcriptomics reveals brain-wide circadian disruption in an Alzheimer's disease model.bioRxiv2026https://conductscience.org/library/papers/41659563PubMed
41,193,527Neuronal type-specific modulation of cognition and AP-1 signaling by early-life rearing conditions.Nat Commun2025https://conductscience.org/library/papers/41193527PubMed
40,841,540Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus.Nat Commun2025https://conductscience.org/library/papers/40841540PubMed
40,604,315Stress-induced reduction of sodium leak currents causes social deficits by impairing dorsal dentate gyrus-medial septum glutamatergic projection.Mol Psychiatry2025https://conductscience.org/library/papers/40604315PubMed
40,415,427[Enriched environment reduces pyramidal neuron excitability in the anterior cingulate cortex to alleviate restraint stress-induced anxiety-like behaviors in mice].Nan Fang Yi Ke Da Xue Xue Bao2025https://conductscience.org/library/papers/40415427PubMed

1 to 10 of 73

See all 73 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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