Paper · 299884

Phorbol myristate acetate: a mitogen selective for a T-lymphocyte subpopulation.

Touraine JL and 5 others. J Exp Med, 1977. Cited by 230 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Phorbol myristate acetate: a mitogen selective for a T-lymphocyte subpopulation. Papers, record 299884. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/299884

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Phorbol myristate acetate: a mitogen selective for a T-lymphocyte subpopulation.; PubMed
Journal: J Exp Med; PubMed
Year: 1977; PubMed
Publication types: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/299884/; PubMed
DOI: https://doi.org/10.1084/jem.145.2.460; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2180613/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 230; iCite
Relative citation ratio, by iCite: 4.97; iCite
Revised in PubMed: 2019-05-08; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Touraine JL	J L
2	Hadden JW	J W
3	Touraine F	F
4	Hadden EM	E M
5	Estensen R	R
6	Good RA	R A

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Lymphocyte Activation	Major topic
Phorbols	Major topic
T-Lymphocytes	Major topic
Tetradecanoylphorbol Acetate	Major topic
Animals
Concanavalin A
Dose-Response Relationship, Drug
Erythrocytes
Humans
Immune Adherence Reaction
Lectins
Mitogens
Sheep
Stimulation, Chemical

Source PubMed

Grants0

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None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References11

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,110,485	Thymus-derived lymphocytes: humoral and cellular reactions distinguished by hydrocortisone.	Science	1972	https://conductscience.org/library/papers/4110485	PubMed
2	4,333,422	Activation of cell membrane enzymes in the stimulation of cell division.	Biochem Biophys Res Commun	1972	https://conductscience.org/library/papers/4333422	PubMed
3	4,305,962	Tumor-promoting agents in two-stage carcinogenesis.	Prog Exp Tumor Res	1969	https://conductscience.org/library/papers/4305962	PubMed
4	4,609,010	Synergistic action of phorbol esters in mitogen-activated bovine lymphocytes.	Exp Cell Res	1974	https://conductscience.org/library/papers/4609010	PubMed
5	4,549,205	Human lymphocyte-sheep erythrocyte rosette formation: some characteristics of the interaction.	Clin Immunol Immunopathol	1973	https://conductscience.org/library/papers/4549205	PubMed
6	1,057,182	Modulation of lymphocyte mitogenesis.	Proc Natl Acad Sci U S A	1975	https://conductscience.org/library/papers/1057182	PubMed
7	1,092,798	Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.	J Exp Med	1975	https://conductscience.org/library/papers/1092798	PubMed
8	1,083,887	Separation of helper T cells from suppressor T cells expressing different Ly components. I. Polyclonal activation: suppressor and helper activities are inherent properties of distinct T-cell subclasses.	J Exp Med	1976	https://conductscience.org/library/papers/1083887	PubMed
9	1,082,097	Different Ly antigen phenotypes of in vitro induced helper and suppressor cells.	Nature	1975	https://conductscience.org/library/papers/1082097	PubMed
10	1,079,428	Thymosin: effects on normal human blood T-cells.	Ann N Y Acad Sci	1975	https://conductscience.org/library/papers/1079428	PubMed

1 to 10 of 11

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Cited by42

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 230 citations.

PMID	Title	Journal	Year	In Papers	Source
42,853,951	Cell heterogeneity contributes to the variable response of HIV-1 to latency-reversing agents.	Sci Adv	2026	https://conductscience.org/library/papers/42853951	PubMed
40,374,622	TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis.	Nat Commun	2025	https://conductscience.org/library/papers/40374622	PubMed
36,560,951	Identification of antibodies cross-reactive with woodchuck immune cells and activation of virus-specific and global cytotoxic T cell responses by anti-PD-1 and anti-PD-L1 in experimental chronic hepatitis B and persistent occult hepadnaviral infection.	Front Microbiol	2022	https://conductscience.org/library/papers/36560951	PubMed
34,925,333	The Role of Interferons in Driving Susceptibility to Asthma Following Bronchiolitis: Controversies and Research Gaps.	Front Immunol	2021	https://conductscience.org/library/papers/34925333	PubMed
32,051,267	Integrated Assessment of Viral Transcription, Antigen Presentation, and CD8+ T Cell Function Reveals Multiple Limitations of Class I-Selective Histone Deacetylase Inhibitors during HIV-1 Latency Reversal.	J Virol	2020	https://conductscience.org/library/papers/32051267	PubMed
29,379,043	Early immune anergy towards recall antigens and mitogens in patients at onset of septic shock.	Sci Rep	2018	https://conductscience.org/library/papers/29379043	PubMed
26,455,415	MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation.	Stem Cell Reports	2015	https://conductscience.org/library/papers/26455415	PubMed
23,433,459	The yin and yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression.	Adv Pharmacol	2013	https://conductscience.org/library/papers/23433459	PubMed
22,412,871	Embryonic stem cell-derived factors inhibit T effector activation and induce T regulatory cells by suppressing PKC-θ activation.	PLoS One	2012	https://conductscience.org/library/papers/22412871	PubMed
7,307,337	Comparison of the inhibition by glucocorticosteroids and cyclosporin A of mitogen-stimulated human lymphocyte proliferation.	Clin Exp Immunol	1981	https://conductscience.org/library/papers/7307337	PubMed

1 to 10 of 42

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Genes0

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None in this release.

Drugs0

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None in this release.

Data0

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None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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