Paper · 3022151

A 3' enhancer is required for temporal and tissue-specific transcriptional activation of the chicken adult beta-globin gene.

Choi OR and 1 other. Nature, 1986. Cited by 170 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A 3' enhancer is required for temporal and tissue-specific transcriptional activation of the chicken adult beta-globin gene. Papers, record 3022151. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3022151

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: A 3' enhancer is required for temporal and tissue-specific transcriptional activation of the chicken adult beta-globin gene.; PubMed
Journal: Nature; PubMed
Year: 1986; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/3022151/; PubMed
DOI: https://doi.org/10.1038/323731a0; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 170; iCite
Relative citation ratio, by iCite: 2.93; iCite
Revised in PubMed: 2007-11-14; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Choi OR	O R
2	Engel JD	J D

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Globins	Major topic
Transcription, Genetic	Major topic
Animals
Base Sequence
Chick Embryo
Chickens
Chromosome Mapping
DNA Restriction Enzymes
Deoxyribonuclease I
Fibroblasts
Fluorescent Antibody Technique
Time Factors

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
GM28896	NIGMS NIH HHS	United States	R01GM028896	PubMed and NIH	NIH RePORTER
HL24415	NHLBI NIH HHS	United States	R01HL024415	PubMed and NIH	NIH RePORTER
TW01016	FIC NIH HHS	United States	F06TW001016	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by93

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 170 citations.

PMID	Title	Journal	Year	In Papers	Source
22,958,419	Spatial organization of the chicken beta-globin gene domain in erythroid cells of embryonic and adult lineages.	Epigenetics Chromatin	2012	https://conductscience.org/library/papers/22958419	PubMed
20,023,155	Dissecting the regulatory switches of development: lessons from enhancer evolution in Drosophila.	Development	2010	https://conductscience.org/library/papers/20023155	PubMed
19,700,619	Evolving enhancer-promoter interactions within the tinman complex of the flour beetle, Tribolium castaneum.	Development	2009	https://conductscience.org/library/papers/19700619	PubMed
15,105,444	Developmental stage differences in chromatin subdomains of the beta-globin locus.	Proc Natl Acad Sci U S A	2004	https://conductscience.org/library/papers/15105444	PubMed
12,359,905	cis-Acting Elements for Light Regulation of Pea Ferredoxin I Gene Expression Are Located within Transcribed Sequences.	Plant Cell	1989	https://conductscience.org/library/papers/12359905	PubMed
12,271,054	Arabidopsis GLABROUS1 Gene Requires Downstream Sequences for Function.	Plant Cell	1993	https://conductscience.org/library/papers/12271054	PubMed
11,689,710	Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation.	Mol Cell Biol	2001	https://conductscience.org/library/papers/11689710	PubMed
11,488,473	Quantitative regulation of the Flaveria Me1 gene is controlled by the 3'-untranslated region and sequences near the amino terminus.	Plant Mol Biol	2001	https://conductscience.org/library/papers/11488473	PubMed
11,171,947	New views of evolution and regulation of vertebrate beta-like globin gene clusters from an orphaned gene in marsupials.	Proc Natl Acad Sci U S A	2001	https://conductscience.org/library/papers/11171947	PubMed
10,871,404	HMG I/Y regulates long-range enhancer-dependent transcription on DNA and chromatin by changes in DNA topology.	Nucleic Acids Res	2000	https://conductscience.org/library/papers/10871404	PubMed

1 to 10 of 93

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
DNASE1	1,773	PubTator's text mining	https://conductscience.org/library/genes/1773

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bank	Accession
GENBANK	X04522

Source GENBANK

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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